Cell Biology
AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activationThis work reveals a novel function of WWP1 E3 ligase in the mono-ubiquitination of AMOTL2, which enables the binding and activation of LATS kinases upon contact inhibition.
Tyrosine phosphorylation of lamin A by Src promotes disassembly of nuclear lamina in interphasePhosphorylation of lamin A at tyrosine residue 45 by Src has an adverse effect on the assembly of nuclear lamina, which may be involved in nuclear dysmorphia, genomic instability, and nuclear plasticity in interphase.
Extracellular matrix mediates moruloid-blastuloid morphodynamics in malignant ovarian spheroidsExpression dynamics of basement membrane-like extracellular matrix and fibronectin regulate transitions between solid (moruloid) and cavitational (blastuloid) phenotypes of ovarian cancer spheroids.
Peroxisomes contribute to intracellular calcium dynamics in cardiomyocytes and non-excitable cellsUsing genetically encoded Förster resonance energy transfer calcium sensors for the peroxisome, this study dissects the previously contentious peroxisome involvement in calcium handling in HeLa cells and in cardiomyocytes derived from human induced pluripotent stem cells.
Long noncoding RNA HOTAIR interacts with Y-Box Protein-1 (YBX1) to regulate cell proliferationThe authors determined that HOTAIR specifically bind to YBX1 and promote its nuclear translocation, and then regulating cell proliferation by stimulating the PI3K/Akt and ERK/RSK signaling pathways.
PNKP is required for maintaining the integrity of progenitor cell populations in adult miceKnockout of Pnkp in adult mice impairs the growth of hair follicle, spermatogonial, and neural progenitor populations.
Axon terminals control endolysosome diffusion to support synaptic remodellingEndolysosomes present in the presynaptic terminal move by diffusion constrained by F-actin and increase their mobility during the remodelling of synaptic connectivity to support a local degradative activity.
CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTPCNKSR1 functions as a scaffold protein for activation of an EGFR phosphatase, PTPRH, at the plasma membrane through the exclusive interaction with RhoB-GTP which is constitutively degraded by the CUL3/KCTD10 E3 complex.
Negative correlation of single-cell PAX3:FOXO1 expression with tumorigenicity in rhabdomyosarcomaSingle-cell PAX3:FOXO1 expression in rhabdomyosarcoma is variable. PAX3:FOXO1 low cell states are characterized by more efficient adhesion, migration and tumor-propagating capacity.
Macrophages-induced IL-18–mediated eosinophilia promotes characteristics of pancreatic malignancyThe current study presents first CP murine model that show IL-18–induced eosinophil inflammation-mediated induction of oncogenic proteins and several pathological malignant characteristics.