Cell Biology
Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicityUsing cryo-ET, cell biology, and proteomics, this study shows that aggregating proteins impair the autophagy-lysosomal pathway in neurons by sequestering a subunit of the AP-3 adaptor complex.
Loss of Nup210 results in muscle repair delays and age-associated alterations in muscle integrityThis study describes the the role of a nuclear pore complex protein in mammalian in skeletal muscle maintenance, repair, and function.
Fms-like tyrosine kinase 3 is a regulator of the cardiac side population in miceThis work shows that Flt3 signaling regulates the composition and functionality of the cardiac side population, which could be relevant for cardiovascular homeostasis under Flt3-inhibitory therapies.
Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagyA detailed look at the properties of a novel USP30 inhibitor applied to studies of mitophagy and pexophagy.
MANF supports the inner hair cell synapse and the outer hair cell stereocilia bundle in the cochleaThe authors show in the mouse how the auditory hair cell structural maintenance is perturbed by the inactivation of Manf and the concomitant ER stress, causing early-onset, progressive hearing loss.
Fundamentals of vaping-associated pulmonary injury leading to severe respiratory distressVaping promotes pathological structural remodeling and functional impairment of the cardiopulmonary system in a mouse inhalation model. This model of vaping-associated pulmonary injury (VAPI) demonstrates potential health risks and provides mechanistic insights on cellular and molecular levels.
TGFβ-induced expression of long noncoding lincRNA Platr18 controls breast cancer axonogenesisTumor axonogenesis is an emerging hallmark of cancer and TGF-beta is a well-known cytokine involved in the control of cancer progression. In this study we identify a novel function for the TGF-beta signaling in cancer aggressivity by promoting cancer axonogenesis.
Chromosome length and gene density contribute to micronuclear membrane stabilityChromosome identity regulates the timing of nuclear membrane rupture in micronuclei, in part through an unexpected link between high gene density and improved nuclear lamina organization.
The different activities of RNA G-quadruplex structures are controlled by flanking sequencesThis study demonstrates the dynamic and multifunctional aspects of RNA G4 structures.
Up-regulation of ubiquitin–proteasome activity upon loss of NatA-dependent N-terminal acetylationInactivation of N-terminal acetyltransferase A is found to alter Rpn4 as well as E3 ligase abundance, causing up-regulation of Ubiquitin–proteasome activity. In this context, Tom1 is also identified as a novel chain-elongating enzyme of the UFD-pathway.