Cell Biology
- DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF
Our study demonstrates that in BRAF- and NRAS-mutant MITF-proficient melanoma, the DUSP4 MAPK phosphatase restricts MAPK activation and prevents oncogenic overdose through modulation of MITF function.
- Lack of Hikeshi activates HSF1 activity under normal conditions and disturbs the heat-shock response
Hikeshi mediates proper nucleocytoplasmic distribution of HSP70, which is important for regulating of HSF1 activity and nuclear proteostasis, and adaptive response to heat shock.
- The HDL particle composition determines its antitumor activity in pancreatic cancer
The authors show that particle composition–dependent, efficient HDL-mediated cholesterol depletion induces apoptosis and interferes with the aggressive growth characteristics of pancreatic cancer cells.
- Nuclear ingression of cytoplasmic bodies accompanies a boost in autophagy
We describe a fully new remodeling event of the nuclear envelope surrounding the nucleolus: it partitions into its regular contact with the vacuole and a dramatic internalization of globular cytoplasmic portions within the nucleus.
- Plasmodium SAS4: basal body component of male cell which is dispensable for parasite transmission
This work shows that Plasmodium SAS4 is a part of the basal body and outer centriolar MTOC but not essential for male gamete formation.
- OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection
Mycobacteria up-regulate host kinase OXSR1 preventing potassium efflux and inflammasome activation. Depletion or inhibition of OXSR1 potentiates inflammasome activation and decreases bacterial burden.
- Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28 ubiquitylation
The role of novel Rab40c/CRL5 ubiquitylation complex in regulating PP6 activity and cell migration.
- Systematic identification of ALK substrates by integrated phosphoproteome and interactome analysis
Integrated analysis of the phosphoproteome and interactome of anaplastic lymphoma kinase (ALK)-overexpressing HEK 293 cells revealed 37 ALK substrate candidates, contributing to the improvement of kinase activity prediction.
- Exploring YAP1-centered networks linking dysfunctional CFTR to epithelial–mesenchymal transition
In this work, a systems biology approach identifies potentially dysregulated EMT signaling in CF (including the Hippo, Wnt, TGF-β, p53, and MYC pathways), integrated by YAP1 and TEAD4.
- Map7D2 and Map7D1 facilitate microtubule stabilization through distinct mechanisms in neuronal cells
The microtubule-associated proteins Map7D2 and Map7D1, which belong to the MAP7 family, stabilize microtubules through distinct mechanisms for the control of cell motility and neurite outgrowth.