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Cell Biology

  • Identification of FAM53C as a cytosolic-anchoring inhibitory binding protein of the kinase DYRK1A
    Open Access
    Identification of FAM53C as a cytosolic-anchoring inhibitory binding protein of the kinase DYRK1A

    Yoshihiko Miyata, Eisuke Nishida

    Yoshihiko Miyata ... Eisuke Nishida

    Published 6 October 2023

    A previously uncharacterized protein, FAM53C, is identified as a binding partner for the kinase DYRK1A involved in numerous neurodevelopmental disorders, such as Down syndrome and autism spectrum disorder. FAM53C anchors the DYRK1A-DCAF7 complex within the cell cytoplasm in a kinase-inactive state.

  • Functional plasticity in chromosome–microtubule coupling on the evolutionary time scale
    Open Access
    Functional plasticity in chromosome–microtubule coupling on the evolutionary time scale

    Sundar Ram Sankaranarayanan, Satya Dev Polisetty, Kuladeep Das, Arti Dumbrepatil, Bethan Medina-Pritchard, Martin Singleton, A Arockia Jeyaprakash, Kaustuv Sanyal

    Sundar Ram Sankaranarayanan ... Kaustuv Sanyal

    Published 4 October 2023

    We identify a lethal mutation in a subunit of the Dam1 complex, a chromosome–microtubule coupler in Saccharomyces cerevisiae with point centromeres. However, this mutation is tolerated in organisms with longer regional centromeres, possibly by employing more microtubules to capture each chromosome.

  • FAM111A regulates replication origin activation and cell fitness
    Open Access
    FAM111A regulates replication origin activation and cell fitness

    Diana O Rios-Szwed, Vanesa Alvarez, Luis Sanchez-Pulido, Elisa Garcia-Wilson, Hao Jiang, Susanne Bandau, Angus Lamond, Constance Alabert

    Diana O Rios-Szwed ... Constance Alabert

    Published 4 October 2023

    Tight control of FAM111A is essential to maintain cellular homeostasis: FAM111A depletion impairs DNA replication, whereas its unrestrained expression leads to ssDNA formation and cell death.

  • Peptide derived from SLAMF1 prevents TLR4-mediated inflammation in vitro and in vivo
    Open Access
    Peptide derived from SLAMF1 prevents TLR4-mediated inflammation in vitro and in vivo

    Kaja Elisabeth Nilsen, Boyao Zhang, Astrid Skjesol, Liv Ryan, Hilde Vagle, Maren Helene Bøe, Pontus Orning, Hera Kim, Siril Skaret Bakke, Kirusika Elamurugan, Ingvild Bergdal Mestvedt, Jørgen Stenvik, Harald Husebye, Egil Lien, Terje Espevik, Maria Yurchenko

    Kaja Elisabeth Nilsen ... Maria Yurchenko

    Published 3 October 2023

    SLAMF1-derived peptide P7 inhibits TLR4-mediated signaling and prevents animal death in mice subjected to LPS shock by blocking TIRAP–MyD88 interaction and TRAM recruitment to TLR4.

  • Two domains of Tim50 coordinate translocation of proteins across the two mitochondrial membranes
    Open Access
    Two domains of Tim50 coordinate translocation of proteins across the two mitochondrial membranes

    Marcel G Genge, Shalini Roy Chowdhury, Vít Dohnálek, Kaori Yunoki, Takashi Hirashima, Toshiya Endo, Pavel Doležal, Dejana Mokranjac

    Marcel G Genge ... Dejana Mokranjac

    Published 25 September 2023

    Biochemical and genetic experiments identify distinct roles of the two domains of Tim50 in the intermembrane space during translocation of proteins into the mitochondria via the TOM and TIM23 complexes.

  • SiR-DNA/SiR–Hoechst-induced chromosome entanglement generates severe anaphase bridges and DNA damage
    Open Access
    SiR-DNA/SiR–Hoechst-induced chromosome entanglement generates severe anaphase bridges and DNA damage

    Girish Rajendraprasad, Sergi Rodriguez-Calado, Marin Barisic

    Girish Rajendraprasad ... Marin Barisic

    Published 19 September 2023

    Live-cell imaging-based study calls for caution when using SiR-DNA, as it induces chromosome entanglement that severely impairs sister chromatid segregation in mitosis, consequently causing DNA damage.

  • MAST4 promotes primary ciliary resorption through phosphorylation of Tctex-1
    Open Access
    MAST4 promotes primary ciliary resorption through phosphorylation of Tctex-1

    Kensuke Sakaji, Sara Ebrahimiazar, Yasuhiro Harigae, Kenichi Ishibashi, Takeya Sato, Takeo Yoshikawa, Gen-ichi Atsumi, Ching-Hwa Sung, Masaki Saito

    Kensuke Sakaji ... Masaki Saito

    Published 19 September 2023

    The mechanism that underlies cilium resorption is not well understood. This study reveals the microtubule-associated serine/threonine kinase family member 4 (MAST4) is a novel kinase that promotes ciliary resorption by localizing ciliary base-phosphorylation of Tctex-1 at Thr94 and its downstream effectors.

  • RB loss sensitizes cells to replication-associated DNA damage after PARP inhibition by trapping
    Open Access
    RB loss sensitizes cells to replication-associated DNA damage after PARP inhibition by trapping

    Luis Gregory Zamalloa, Margaret M Pruitt, Nicole M Hermance, Himabindu Gali, Rachel L Flynn, Amity L Manning

    Luis Gregory Zamalloa ... Amity L Manning

    Published 13 September 2023

    After PARP inhibition by trapping, cells lacking the RB tumor suppressor experience persistent replication stress and genomic instability that compromise cell viability.

  • KIF16B drives MT1-MMP recycling in macrophages and promotes co-invasion of cancer cells
    Open Access
    KIF16B drives MT1-MMP recycling in macrophages and promotes co-invasion of cancer cells

    Sven Hey, Christiane Wiesner, Bryan Barcelona, Stefan Linder

    Sven Hey ... Stefan Linder

    Published 11 September 2023

    Recycling of the metalloproteinase MT1-MMP by the motor KIF16B regulates 3D invasion of macrophages, and also co-invasion of cancer cells, pointing to a role of KIF16B in the tumor microenvironment.

  • Control of Paneth cell function by HuR regulates gut mucosal growth by altering stem cell activity
    Open Access
    Control of Paneth cell function by HuR regulates gut mucosal growth by altering stem cell activity

    Lan Xiao, Bridgette Warner, Caroline G Mallard, Hee K Chung, Amol Shetty, Christine A Brantner, Jaladanki N Rao, Gregory S Yochum, Walter A Koltun, Kathleen B To, Douglas J Turner, Myriam Gorospe, Jian-Ying Wang

    Lan Xiao ... Jian-Ying Wang

    Published 11 September 2023

    HuR stimulates the activity of intestinal stem cells by enhancing Paneth cell function via activation of mitochondrial metabolism, thus promoting renewal of the intestinal mucosa.

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