Cell Biology
- The RNA-binding protein Msi2 regulates autophagy during myogenic differentiation
This study identifies the RNA-binding protein Musashi2 as a novel regulator of myogenesis. Msi2 regulates myoblast differentiation via controlling autophagic protein LC3 expression. Loss of Msi2 results in defective skeletal muscle function in vivo.
- Oxidative phosphorylation is a pivotal therapeutic target of fibrodysplasia ossificans progressiva
Oxidative phosphorylation plays a pivotal role in heterotopic ossification associated with fibrodysplasia ossificans progressiva, underscoring its potential as a significant therapeutic target.
- Correction: Profiling subcellular localization of nuclear-encoded mitochondrial gene products in zebrafish
The vast majority (99%) of mitochondrial proteins are encoded by the nuclear genome, synthesized in the cytosol and imported into the organelle. Here we study the principles of mitochondrial import in vivo from the RNA perspective using zebrafish.
- Apical dehydration impairs the cystic fibrosis airway epithelium barrier via a β1-integrin/YAP1 pathway
Dehydration of the airway epithelial cell surface, a hallmark of CF, increases plasma membrane tension, resulting in altered Hippo signaling associated with the loss of barrier function.
- Knockout of PA200 improves proteasomal degradation and myelination in a proteotoxic neuropathy
Proteasome Activator 200 is upregulated in a neuropathy model in which protein degradation by the proteasome is impaired. Knocking out PA200 unexpectedly rescued proteostasis and prevented neuropathy.
- Micronucleus is not a potent inducer of the cGAS/STING pathway
The FuVis2 reporter system, designed to visualize cell nuclei harboring sister chromatid fusion, equipped with cGAS/STING reporters, offers critical insights that micronuclei are primarily captured by cGAS during mitosis but do not lead to STING activation.
- FERM domain–containing proteins are active components of the cell nucleus
The information we gathered from the literature reveals that FERM domain proteins perform important and diverse functions not only in the cytoplasm, but also in the cell nucleus.
- A feedback loop that drives cell death and proliferation and its defect in intestinal stem cells
A positive feedback circuit that simultaneously drives cell death and proliferation and its defect in intestinal stem cells in Drosophila were discovered.
- Drosophila MIC10b can polymerize into cristae-shaping filaments
DmMIC10b, the primary MIC10 orthologue in Drosophila, is crucial for MICOS stability and mitochondrial ultrastructure and exhibits a distinctive ability to form filaments, impacting mitochondrial cristae architecture.
- The LINC complex ensures accurate centrosome positioning during prophase
Centrosome positioning in prophase is essential for efficient spindle assembly. Here, we show that centrosome positioning requires LINC complex–mediated loading of dynein on the nuclear envelope.