Cell Biology
DCAF14 regulates CDT2 to promote SET8-dependent replication fork protectionDCAF14 modulates CRL4CDT2-dependent turnover during DNA replication. Loss of DCAF14 causes nascent strand degradation due to excessive proteasomal turnover of SET8 by aberrant CDT2 activity.
ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasisA protein complex composed of the outer mitochondrial membrane protein SYNJ2BP and the endoplasmic reticulum protein ESYT1 tethers the two organelles to facilitate calcium and lipid transfer.
Enucleation of the C. elegans embryo revealed dynein-dependent spacing between microtubule astersUsing a genetic trick to produce enucleated C. elegans embryos, the authors revealed how the microtubule asters take space between each other inside the cell.
Clathrin light chains CLCa and CLCb have non-redundant roles in epithelial lumen formationDeletion of genes encoding vertebrate clathrin light chain isoforms reveals a role for both in epithelial lumen formation and dominance of CLCa function in vivo during uterine epithelium development.
Biogenesis, inheritance, and 3D ultrastructure of the microsporidian mitosomeQuantitative electron and light microscopy combined with bioinformatics reveal that microsporidian mitosomes grow and divide incrementally and are inherited at the microsporidian centrosome (spindle pole body), whereas mitochondrial dynamins participate in mitosome division.
NRF2 connects Src tyrosine kinase to ferroptosis resistance in glioblastomaThe hyperactivation of Src tyrosine kinase in glioblastoma leads to the constitutive stabilization and activation of NRF2, thus causing resistance to ionizing radiation-induced ferroptosis.
Role of ciliopathy protein TMEM107 in eye development: insights from a mouse model and retinal organoidTMEM107 plays a crucial role in early vertebrate eye development and ciliogenesis in the differentiating retina, and its absence leads to eye defects and impaired retinal organoid formation.
Passive diffusion accounts for the majority of intracellular nanovesicle transportIn contrast to large vesicles and organelles that are moved by motors inside cells, a detailed analysis of intracellular vesicle mobility reveals that passive diffusion is the main mode of small vesicle transport.
Fn14 promotes myoblast fusion during regenerative myogenesisGenetic and molecular approaches demonstrate that Fn14 receptor–mediated signaling improves myoblast fusion during skeletal muscle regeneration in a cell-autonomous manner.
Determinants of cytoplasmic microtubule depolymerization during ciliogenesis in ChlamydomonasChemically induced deciliation previously shown to induce cytoplasmic microtubule depolymerization occurs independently of ciliary loss. Furthermore, immediate ciliogenesis can occur in the presence of polymerized cytoplasmic microtubules.