Cell Biology
- The cation exchanger Letm1, circadian rhythms, and NAD(H) levels interconnect in diurnal zebrafish
The mitochondrial osmoregulator Letm1 exhibits a diel regulation, impacts on NAD+/H levels, circadian genes, and its study allows new perspectives on possible genetic compensation mechanisms.
- LncRNA RUS shapes the gene expression program towards neurogenesis
The chromatin-associated lncRNA RUS binds in the vicinity to neural differentiation-associated genes and regulates them in a context-dependent manner to enable proper neuron development.
- ERK-Smurf1-RhoA signaling is critical for TGFβ-drived EMT and tumor metastasis
The research uncovers a non-canonical role of ERK in TGF-beta-induced EMT, revealing ERK-mediated phosphorylation of Smurf1 is required for its sufficient binding to RhoA and the subsequent RhoA turnover.
- VDAC1 negatively regulates melanogenesis through the Ca2+-calcineurin-CRTC1-MITF pathway
This study revealed an important and novel role of mitochondrial VDAC1 in regulating melanogenesis in resting melanocytes through a Ca2+-regulated pathway that is independent of the alpha-MSH/UVB pathway.
- Axonal transport of Hrs is activity dependent and facilitates synaptic vesicle protein degradation
This study describes an activity-dependent mechanism for transporting ESCRT-0 protein Hrs to synaptic vesicle (SV) pools, facilitating SV protein degradation in response to increased neuronal firing.
- Lack of Hikeshi activates HSF1 activity under normal conditions and disturbs the heat-shock response
Hikeshi mediates proper nucleocytoplasmic distribution of HSP70, which is important for regulating of HSF1 activity and nuclear proteostasis, and adaptive response to heat shock.
- DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF
Our study demonstrates that in BRAF- and NRAS-mutant MITF-proficient melanoma, the DUSP4 MAPK phosphatase restricts MAPK activation and prevents oncogenic overdose through modulation of MITF function.
- The HDL particle composition determines its antitumor activity in pancreatic cancer
The authors show that particle composition–dependent, efficient HDL-mediated cholesterol depletion induces apoptosis and interferes with the aggressive growth characteristics of pancreatic cancer cells.
- Nuclear ingression of cytoplasmic bodies accompanies a boost in autophagy
We describe a fully new remodeling event of the nuclear envelope surrounding the nucleolus: it partitions into its regular contact with the vacuole and a dramatic internalization of globular cytoplasmic portions within the nucleus.
- Plasmodium SAS4: basal body component of male cell which is dispensable for parasite transmission
This work shows that Plasmodium SAS4 is a part of the basal body and outer centriolar MTOC but not essential for male gamete formation.