Cell Biology
Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytesUbiquitin signals the sorting of Cx43 into EVs, which is impaired during ischemia, resulting in decreased levels of Cx43 in cardiomyocyte-derived and circulating EVs from myocardial infarcted patients.
Brain is an endocrine organ through secretion and nuclear transfer of parathymosinThe hypothalamus and brain neurons orchestrate the secretion and nuclear transfer of PTMS which is neuroprotective against aging-related disorders.
MicroRNA regulation of murine trophoblast stem cell self-renewal and differentiationPost-transcriptional regulation of CDX2 and cell cycle genes by miR-290 and miR-322 clusters along with transactivation of miR-290 cluster and cyclin D1 by CDX2 equipoise trophoblast stem cell self-renewal and differentiation.
An atlas of human proximal epididymis reveals cell-specific functions and distinct roles for CFTRA coordinated process of maturation in the lumen of the epididymis is required for sperm to fertilize an egg. A single cell atlas of the human proximal epididymis reveals key cell-specific functions, regional specialization, and two roles for CFTR.
Plasma membrane phosphatidylinositol (4,5)-bisphosphate promotes Weibel–Palade body exocytosisPhosphatidylinositol (4,5)-bisphosphate transiently accumulates at sites of Weibel–Palade body–plasma membrane fusion and promotes agonist-evoked exocytosis of endothelial von-Willebrand factor.
PGE2 accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smokingDysregulation of self-renewal contributes to alterations in alveolar macrophages (AMs). In this study, Penke et al identify PGE2 as a suppressor of AM proliferation, whose divergent bioavailability in aged and cigarette smoke-exposed mice could explain opposite effects on AM numbers.
The RECQL helicase prevents replication fork collapse during replication stressThis work shows that RECQL is an essential player in the protection of stalled replication forks and possibly the restart of broken replication forks, thereby representing a target for cancer therapy.
The bacterial quorum sensing signal DSF hijacks Arabidopsis thaliana sterol biosynthesis to suppress plant innate immunityThis study highlights that DSF, the quorum sensing signal produced by bacterial phytopathogens, is able to directly modulate plant plasma membrane dynamics by interfering with host lipid profile and thereby, suppress plant immunity responses.
MIC26 and MIC27 cooperate to regulate cardiolipin levels and the landscape of OXPHOS complexesApolipoproteins of MICOS, MIC26 and MIC27, cooperatively manage cristae structure, cardiolipin levels, and the global stability and integrity of respiratory chain supercomplexes and F1Fo–ATP synthase.
Evolutionary divergence reveals the molecular basis of EMRE dependence of the human MCUUsing clues from evolution, chimeric proteins, and biochemical methods, this work identifies a new domain in mitochondrial calcium uniporter that determines its dependence on its binding partner EMRE.