Cell Biology
Rapid ER remodeling induced by a peptide–lipid complex in dying tumor cellsAlpha1-oleate induces novel ER remodeling, causing peripheral ER loss, vesiculation, and nuclear entry, expanding the nuclear ER with its content of dying cell debris.
Divergent Plasmodium kinases drive MTOC, kinetochore and axoneme organisation in male gametogenesisThis study reveals how Plasmodium kinases regulate MTOC, axoneme, and kinetochore organisation in male gametogenesis, providing key insights into potential targets for malaria transmission control.
The late-onset Alzheimer’s disease risk factor RHBDF2 is a modifier of microglial TREM2 proteolysisThis study demonstrates that the Alzheimer’s disease risk factor iRhom2/RHBDF2 is a modifier of microglial TREM2 proteolysis and establishes ADAM17 as a physiological TREM2 protease in microglia.
Lipid-driven Src self-association modulates its transformation capacityLipid-mediated condensates formed by Src on supported lipid membranes are dependent of a conserved lysine cluster in its SH4 domain and modulate its transforming capacity.
MDC1 mediates Pellino recruitment to sites of DNA double-strand breaksRING E3 ubiquitin ligases Pellino 1 and 2 are recruited to sites of DNA damage via their non-canonical FHA domains that recognise conserved phosphorylated sequence motifs in the DNA damage adaptor protein MDC1.
Reversible and effective cell cycle synchronization method for studying stage-specific processesReversible and effective cell cycle synchronization (CellSync).
Identification of TNFAIP2 as a unique cellular regulator of CSF-1 receptor activationThis study demonstrates the molecular mechanism and biological significance of the formation of large CSF-1 receptor aggregates in macrophages.
A biallelic variant in GORASP1 causes a novel Golgipathy with glycosylation and mitotic defectsThis study identifies the first human pathogenic variant in GORASP1, the gene encoding the Golgi stacking protein GRASP65, and demonstrates its consequences on glycosylation and mitotic progression.
Screening of homing and tissue-penetrating peptides by microdialysis and in vivo phage displayIn vivo phage display combined with microdialysis can be used for the discovery of vascular homing peptides capable of extravasation and tissue penetration in the target organ.
Visualisation of Euglena gracilis organelles and cytoskeleton using expansion microscopyWe applied expansion microscopy to visualise the cytoskeleton, mitochondria, and chloroplasts of Euglena gracilis, which enabled high-resolution imaging, revealing cellular structures and organelle development, demonstrating expansion microscopy’s utility as a complementary method to electron microscopy for studying this protist.