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Cell Biology

  • The cation exchanger Letm1, circadian rhythms, and NAD(H) levels interconnect in diurnal zebrafish
    Open Access
    The cation exchanger Letm1, circadian rhythms, and NAD(H) levels interconnect in diurnal zebrafish

    Pauline Dao, Stefan Hajny, Ronald Mekis, Lukas Orel, Nora Dinhopl, Kristin Tessmar-Raible, Karin Nowikovsky

    Pauline Dao ... Karin Nowikovsky

    Published 13 June 2022

    The mitochondrial osmoregulator Letm1 exhibits a diel regulation, impacts on NAD+/H levels, circadian genes, and its study allows new perspectives on possible genetic compensation mechanisms.

  • LncRNA <em>RUS</em> shapes the gene expression program towards neurogenesis
    Open Access
    LncRNA RUS shapes the gene expression program towards neurogenesis

    Marius F Schneider, Veronika Müller, Stephan A Müller, Stefan F Lichtenthaler, Peter B Becker, Johanna C Scheuermann

    Marius F Schneider ... Johanna C Scheuermann

    Published 10 June 2022

    The chromatin-associated lncRNA RUS binds in the vicinity to neural differentiation-associated genes and regulates them in a context-dependent manner to enable proper neuron development.

  • ERK-Smurf1-RhoA signaling is critical for TGFβ-drived EMT and tumor metastasis
    Open Access
    ERK-Smurf1-RhoA signaling is critical for TGFβ-drived EMT and tumor metastasis

    Jianzhong Zheng, Zhiyuan Shi, Pengbo Yang, Yue Zhao, Wenbin Tang, Shaopei Ye, Zuodong Xuan, Chen Chen, Chen Shao, Qingang Wu, Huimin Sun

    Jianzhong Zheng ... Huimin Sun

    Published 2 June 2022

    The research uncovers a non-canonical role of ERK in TGF-beta-induced EMT, revealing ERK-mediated phosphorylation of Smurf1 is required for its sufficient binding to RhoA and the subsequent RhoA turnover.

  • VDAC1 negatively regulates melanogenesis through the Ca<sup>2+</sup>-calcineurin-CRTC1-MITF pathway
    Open Access
    VDAC1 negatively regulates melanogenesis through the Ca2+-calcineurin-CRTC1-MITF pathway

    Jianli Wang, Juanjuan Gong, Qiaochu Wang, Tieshan Tang, Wei Li

    Jianli Wang ... Wei Li

    Published 1 June 2022

    This study revealed an important and novel role of mitochondrial VDAC1 in regulating melanogenesis in resting melanocytes through a Ca2+-regulated pathway that is independent of the alpha-MSH/UVB pathway.

  • Axonal transport of Hrs is activity dependent and facilitates synaptic vesicle protein degradation
    Open Access
    Axonal transport of Hrs is activity dependent and facilitates synaptic vesicle protein degradation

    Veronica Birdsall, Konner Kirwan, Mei Zhu, Yuuta Imoto, Scott M Wilson, Shigeki Watanabe, Clarissa L Waites

    Veronica Birdsall ... Clarissa L Waites

    Published 30 May 2022

    This study describes an activity-dependent mechanism for transporting ESCRT-0 protein Hrs to synaptic vesicle (SV) pools, facilitating SV protein degradation in response to increased neuronal firing.

  • Lack of Hikeshi activates HSF1 activity under normal conditions and disturbs the heat-shock response
    Open Access
    Lack of Hikeshi activates HSF1 activity under normal conditions and disturbs the heat-shock response

    Shingo Kose, Kenichiro Imai, Ai Watanabe, Akira Nakai, Yutaka Suzuki, Naoko Imamoto

    Shingo Kose ... Naoko Imamoto

    Published 17 May 2022

    Hikeshi mediates proper nucleocytoplasmic distribution of HSP70, which is important for regulating of HSF1 activity and nuclear proteostasis, and adaptive response to heat shock.

  • DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF
    Open Access
    DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF

    Nuria Gutierrez-Prat, Hedwig L Zuberer, Luca Mangano, Zahra Karimaddini, Luise Wolf, Stefka Tyanova, Lisa C Wellinger, Daniel Marbach, Vera Griesser, Piergiorgio Pettazzoni, James R Bischoff, Daniel Rohle, Chiara Palladino, Igor Vivanco

    Nuria Gutierrez-Prat ... Igor Vivanco

    Published 17 May 2022

    Our study demonstrates that in BRAF- and NRAS-mutant MITF-proficient melanoma, the DUSP4 MAPK phosphatase restricts MAPK activation and prevents oncogenic overdose through modulation of MITF function.

  • The HDL particle composition determines its antitumor activity in pancreatic cancer
    Open Access
    The HDL particle composition determines its antitumor activity in pancreatic cancer

    Raimund Oberle, Kristina Kührer, Tamina Österreicher, Florian Weber, Stefanie Steinbauer, Florian Udonta, Mark Wroblewski, Isabel Ben-Batalla, Ingrid Hassl, Jakob Körbelin, Matthias Unseld, Matti Jauhiainen, Birgit Plochberger, Clemens Röhrl, Markus Hengstschläger, Sonja Loges, Herbert Stangl

    Raimund Oberle ... Herbert Stangl

    Published 16 May 2022

    The authors show that particle composition–dependent, efficient HDL-mediated cholesterol depletion induces apoptosis and interferes with the aggressive growth characteristics of pancreatic cancer cells.

  • Nuclear ingression of cytoplasmic bodies accompanies a boost in autophagy
    Open Access
    Nuclear ingression of cytoplasmic bodies accompanies a boost in autophagy

    Manon Garcia, Sylvain Kumanski, Alberto Elías-Villalobos, Chantal Cazevieille, Caroline Soulet, María Moriel-Carretero

    Manon Garcia ... María Moriel-Carretero

    Published 13 May 2022

    We describe a fully new remodeling event of the nuclear envelope surrounding the nucleolus: it partitions into its regular contact with the vacuole and a dramatic internalization of globular cytoplasmic portions within the nucleus.

  • <em>Plasmodium</em> SAS4: basal body component of male cell which is dispensable for parasite transmission
    Open Access
    Plasmodium SAS4: basal body component of male cell which is dispensable for parasite transmission

    Mohammad Zeeshan, Declan Brady, Robert Markus, Sue Vaughan, David Ferguson, Anthony A Holder, Rita Tewari

    Mohammad Zeeshan ... Rita Tewari

    Published 12 May 2022

    This work shows that Plasmodium SAS4 is a part of the basal body and outer centriolar MTOC but not essential for male gamete formation.

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