Cell Biology
The cation exchanger Letm1, circadian rhythms, and NAD(H) levels interconnect in diurnal zebrafishThe mitochondrial osmoregulator Letm1 exhibits a diel regulation, impacts on NAD+/H levels, circadian genes, and its study allows new perspectives on possible genetic compensation mechanisms.
LncRNA RUS shapes the gene expression program towards neurogenesisThe chromatin-associated lncRNA RUS binds in the vicinity to neural differentiation-associated genes and regulates them in a context-dependent manner to enable proper neuron development.
ERK-Smurf1-RhoA signaling is critical for TGFβ-drived EMT and tumor metastasisThe research uncovers a non-canonical role of ERK in TGF-beta-induced EMT, revealing ERK-mediated phosphorylation of Smurf1 is required for its sufficient binding to RhoA and the subsequent RhoA turnover.
VDAC1 negatively regulates melanogenesis through the Ca2+-calcineurin-CRTC1-MITF pathwayThis study revealed an important and novel role of mitochondrial VDAC1 in regulating melanogenesis in resting melanocytes through a Ca2+-regulated pathway that is independent of the alpha-MSH/UVB pathway.
Axonal transport of Hrs is activity dependent and facilitates synaptic vesicle protein degradationThis study describes an activity-dependent mechanism for transporting ESCRT-0 protein Hrs to synaptic vesicle (SV) pools, facilitating SV protein degradation in response to increased neuronal firing.
Lack of Hikeshi activates HSF1 activity under normal conditions and disturbs the heat-shock responseHikeshi mediates proper nucleocytoplasmic distribution of HSP70, which is important for regulating of HSF1 activity and nuclear proteostasis, and adaptive response to heat shock.
DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITFOur study demonstrates that in BRAF- and NRAS-mutant MITF-proficient melanoma, the DUSP4 MAPK phosphatase restricts MAPK activation and prevents oncogenic overdose through modulation of MITF function.
The HDL particle composition determines its antitumor activity in pancreatic cancerThe authors show that particle composition–dependent, efficient HDL-mediated cholesterol depletion induces apoptosis and interferes with the aggressive growth characteristics of pancreatic cancer cells.
Nuclear ingression of cytoplasmic bodies accompanies a boost in autophagyWe describe a fully new remodeling event of the nuclear envelope surrounding the nucleolus: it partitions into its regular contact with the vacuole and a dramatic internalization of globular cytoplasmic portions within the nucleus.
Plasmodium SAS4: basal body component of male cell which is dispensable for parasite transmissionThis work shows that Plasmodium SAS4 is a part of the basal body and outer centriolar MTOC but not essential for male gamete formation.