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Cell Biology

  • ER targeting of non-imported mitochondrial carrier proteins is dependent on the GET pathway
    Open Access
    ER targeting of non-imported mitochondrial carrier proteins is dependent on the GET pathway

    Tianyao Xiao, Viplendra PS Shakya, Adam L Hughes

    Tianyao Xiao ... Adam L Hughes

    Published 21 January 2021

    The GET pathway is required to target non-imported mitochondrial carrier proteins to the endoplasmic reticulum, which prevents their deposition into Hsp42-dependent protein foci.

  • Reduced RNA turnover as a driver of cellular senescence
    Open Access
    Reduced RNA turnover as a driver of cellular senescence

    Nowsheen Mullani, Yevheniia Porozhan, Adèle Mangelinck, Christophe Rachez, Mickael Costallat, Eric Batsché, Michele Goodhardt, Giovanni Cenci, Carl Mann, Christian Muchardt

    Nowsheen Mullani ... Christian Muchardt

    Published 14 January 2021

    RNAs originating from transcription upstream and downstream of genes accumulate in the cytoplasm of a subset of senescent cells, suggesting an RNA alternative to cytoplasmic DNA in the triggering of senescence.

  • Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1
    Open Access
    Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1

    Helena Silva Cascales, Kamila Burdova, Anna Middleton, Vladislav Kuzin, Erik Müllers, Henriette Stoy, Laura Baranello, Libor Macurek, Arne Lindqvist

    Helena Silva Cascales ... Arne Lindqvist

    Published 5 January 2021

    Main mitotic kinases as PLK1 are activated at the S/G2 transition. A change in Cyclin A2 localisation at the S/G2 transition enables activation of PLK1.

  • HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails
    Open Access
    HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails

    Pablo Barbeito, Yuki Tachibana, Raquel Martin-Morales, Paula Moreno, Kirk Mykytyn, Tetsuo Kobayashi, Francesc R Garcia-Gonzalo

    Pablo Barbeito ... Francesc R Garcia-Gonzalo

    Published 28 December 2020

    Ciliary accumulation of G protein–coupled receptors HTR6 and SSTR3 depends on redundant ciliary targeting sequences acting via ciliary trafficking adapters TULP3 and RABL2.

  • FAM83F regulates canonical Wnt signalling through an interaction with CK1α
    Open Access
    FAM83F regulates canonical Wnt signalling through an interaction with CK1α

    Karen Dunbar, Rebecca A Jones, Kevin Dingwell, Thomas J Macartney, James C Smith, Gopal P Sapkota

    Karen Dunbar ... Gopal P Sapkota

    Published 24 December 2020

    FAM83F directs CK1α to the plasma membrane, and through its association with CK1α, FAM83F mediates canonical Wnt signalling.

  • IMiDs induce FAM83F degradation via an interaction with CK1α to attenuate Wnt signalling
    Open Access
    IMiDs induce FAM83F degradation via an interaction with CK1α to attenuate Wnt signalling

    Karen Dunbar, Thomas J Macartney, Gopal P Sapkota

    Karen Dunbar ... Gopal P Sapkota

    Published 23 December 2020

    IMiDs induce the degradation of the FAM83F–CK1α complex but no other FAM83–CK1α complexes, resulting in attenuation of Wnt signalling.

  • Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4
    Open Access
    Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4

    Andreia Mendes, Julien P Gigan, Christian Rodriguez Rodrigues, Sébastien A Choteau, Doriane Sanseau, Daniela Barros, Catarina Almeida, Voahirana Camosseto, Lionel Chasson, Adrienne W Paton, James C Paton, Rafael J Argüello, Ana-Maria Lennon-Duménil, Evelina Gatti, Philippe Pierre

    Andreia Mendes ... Philippe Pierre

    Published 21 December 2020

    Differentiated dendritic cells display an unusual activation of the integrated stress response, which is necessary for normal type-I Interferon production and cell migration.

  • Degradation of arouser by endosomal microautophagy is essential for adaptation to starvation in <em>Drosophila</em>
    Open Access
    Degradation of arouser by endosomal microautophagy is essential for adaptation to starvation in Drosophila

    Anne-Claire Jacomin, Raksha Gohel, Zunoon Hussain, Agnes Varga, Tamas Maruzs, Mark Eddison, Margaux Sica, Ashish Jain, Kevin G Moffat, Terje Johansen, Andreas Jenny, Gabor Juhasz, Ioannis P Nezis

    Anne-Claire Jacomin ... Ioannis P Nezis

    Published 14 December 2020

    Drosophila EPS8-family protein Arouser is constitutively degraded by endosomal microautophagy; its stabilisation upon starvation is essential to the animal adaptation and survival.

  • SCF<sup>Cdc4</sup> ubiquitin ligase regulates synaptonemal complex formation during meiosis
    Open Access
    SCFCdc4 ubiquitin ligase regulates synaptonemal complex formation during meiosis

    Zhihui Zhu, Mohammad Bani Ismail, Miki Shinohara, Akira Shinohara

    Zhihui Zhu ... Akira Shinohara

    Published 8 December 2020

    During meiosis, homologous chromosomes pair to form the synaptonemal complex (SC). This study showed that SCFCdc4 ubiquitin ligase is required for and works with Pch2 AAA+ ATPase for SC assembly.

  • ESI mutagenesis: a one-step method for introducing mutations into bacterial artificial chromosomes
    Open Access
    ESI mutagenesis: a one-step method for introducing mutations into bacterial artificial chromosomes

    Arnaud Rondelet, Andrei Pozniakovsky, Devika Namboodiri, Richard Cardoso da Silva, Divya Singh, Marit Leuschner, Ina Poser, Andrea Ssykor, Julian Berlitz, Nadine Schmidt, Lea Röhder, Gerben Vader, Anthony A Hyman, Alexander W Bird

    Arnaud Rondelet ... Alexander W Bird

    Published 8 December 2020

    A simple and efficient recombineering-based method for introducing point mutations into bacterial artificial chromosomes using an artificial intron cassette.

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