Cell Biology
Novel imaging tools to study mitochondrial morphology in Caenorhabditis elegansThis study presents novel genetic tools for live imaging of mitochondrial morphology in the nematode Caenorhabditis elegans, offering insights into mitochondrial dynamics and providing a thorough comparison with existing methods.
Mast cell extracellular trap formation underlies vascular and neural injury and hyperalgesia in sickle cell diseaseMast cell extracellular traps catalyzed by peptidylarginine deiminase 4 contribute to vascular stasis and nerve injury, which may contribute to acute and chronic pain in sickle cell disease.
Cell-Int: a cell–cell interaction assay to identify native membrane protein interactionsA cell interaction assay to study membrane protein interactions in quasi-physiological settings, with multiple applications, from deciphering interaction networks to assessing therapeutic molecules.
Mitochondrial double-stranded RNA homeostasis depends on cell-cycle progressionThe accumulation of mitochondrial double-stranded RNA (mt-dsRNA) in cancer cells depends on cell proliferation status. Mt-dsRNA is more abundant in patient lung adenocarcinoma compared with healthy tissue.
Differential modulation of polycomb-associated histone marks by cBAF, pBAF, and gBAF complexesThis study shows that the canonical BAF (cBAF) complex uniquely opposes polycomb-associated repressive marks at the Nkx2-9 gene in mouse embryonic stem cells, leading to transcriptional activation, a function not shared by gBAF or pBAF complexes.
A novel role for CSA in the regulation of nuclear envelope integrity: uncovering a non-canonical functionIdentification of a new function for CSA protein in the regulation of the nuclear envelope, preventing nuclear ruptures and activation of inflammation pathways.
JAK inhibition with tofacitinib rapidly increases contractile force in human skeletal muscleInhibition of JAK activity with tofacitinib rapidly increases human skeletal muscle fiber force by up-regulating smooth muscle myosin light chain kinase, offering a new treatment for muscle weakness.
PPM1G dephosphorylates eIF4E in control of mRNA translation and cell proliferationPPM1G inhibits cell proliferation by targeting phospho-eIF4E–dependent mRNA translation.
Rit1-TBC1D10B signaling modulates FcγR-mediated phagosome formation in RAW264 macrophagesDuring phagocytosis, the signaling molecule Rit1 GTPase promotes the dissociation of TBC1D10B from the phagocytic membrane, thereby disinhibiting phagosome formation mediated by TBC1D10B.
Golgi pH homeostasis stabilizes the lysosomal membrane through N-glycosylation of membrane proteinsGolgi pH imbalance (Gphr deficiency) disrupts lysosomal membrane protein glycosylation, compromising lysosomal membrane stability, highlighting the critical role of the Golgi apparatus.