Cell Biology
Lack of Hikeshi activates HSF1 activity under normal conditions and disturbs the heat-shock responseHikeshi mediates proper nucleocytoplasmic distribution of HSP70, which is important for regulating of HSF1 activity and nuclear proteostasis, and adaptive response to heat shock.
DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITFOur study demonstrates that in BRAF- and NRAS-mutant MITF-proficient melanoma, the DUSP4 MAPK phosphatase restricts MAPK activation and prevents oncogenic overdose through modulation of MITF function.
The HDL particle composition determines its antitumor activity in pancreatic cancerThe authors show that particle composition–dependent, efficient HDL-mediated cholesterol depletion induces apoptosis and interferes with the aggressive growth characteristics of pancreatic cancer cells.
Nuclear ingression of cytoplasmic bodies accompanies a boost in autophagyWe describe a fully new remodeling event of the nuclear envelope surrounding the nucleolus: it partitions into its regular contact with the vacuole and a dramatic internalization of globular cytoplasmic portions within the nucleus.
Plasmodium SAS4: basal body component of male cell which is dispensable for parasite transmissionThis work shows that Plasmodium SAS4 is a part of the basal body and outer centriolar MTOC but not essential for male gamete formation.
OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infectionMycobacteria up-regulate host kinase OXSR1 preventing potassium efflux and inflammasome activation. Depletion or inhibition of OXSR1 potentiates inflammasome activation and decreases bacterial burden.
Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28 ubiquitylationThe role of novel Rab40c/CRL5 ubiquitylation complex in regulating PP6 activity and cell migration.
Systematic identification of ALK substrates by integrated phosphoproteome and interactome analysisIntegrated analysis of the phosphoproteome and interactome of anaplastic lymphoma kinase (ALK)-overexpressing HEK 293 cells revealed 37 ALK substrate candidates, contributing to the improvement of kinase activity prediction.
Exploring YAP1-centered networks linking dysfunctional CFTR to epithelial–mesenchymal transitionIn this work, a systems biology approach identifies potentially dysregulated EMT signaling in CF (including the Hippo, Wnt, TGF-β, p53, and MYC pathways), integrated by YAP1 and TEAD4.
Map7D2 and Map7D1 facilitate microtubule stabilization through distinct mechanisms in neuronal cellsThe microtubule-associated proteins Map7D2 and Map7D1, which belong to the MAP7 family, stabilize microtubules through distinct mechanisms for the control of cell motility and neurite outgrowth.