Cancer
GPER1 links estrogens to centrosome amplification and chromosomal instability in human colon cellsThis study reveals a causal link between (xeno)estrogen-activated GPER1, centriole-positive numerical centrosome amplification, and genomic instability in normal colon and colorectal cancer cells.
Myeloma immunoglobulin rearrangement and translocation detection through targeted capture sequencingTargeted capture sequencing (CapIG-seq) is a novel, efficient, and effective approach to examine multiple genomic alterations in ctDNA and bone marrow aspirates of patients with multiple myeloma.
Direct CD32 T-cell cytotoxicity: implications for breast cancer prognosis and treatmentCD32-chimeric receptor T cell identifies CD32 cell surface ligand(s), on breast cancer (BC) cells, leading to BC cell elimination in vitro and in vivo and allowing detection of genes prognostically relevant.
Whole-exome sequencing of epithelial ovarian carcinomas differing in resistance to platinum therapyExploration of the prognostic and predictive significance of exome variation in epithelial ovarian carcinoma patients, with TP53, Hippo, homologous recombination genes, and the SBS6 signature as the most interesting results.
Non-canonical miRNA-RNA base-pairing impedes tumor suppressor activity of miR-16In uveal melanoma tumors, the RNA decay activity of the tumor suppressor miR-16 is impaired by sponge RNAs. These RNAs defined a powerful signature to predict overall survival.
Mechanistic and pharmacodynamic studies of DuoBody-CD3x5T4 in preclinical tumor modelsThis study provides in-depth insight into the mechanism of action and in vivo pharmacodynamic markers of a CD3x5T4 bispecific antibody in preclinical in vitro and in vivo solid cancer models.
Proteasomal down-regulation of the proapoptotic MST2 pathway contributes to BRAF inhibitor resistance in melanomaThe loss of MST2 pathway protein expression in BRAF inhibitor resistant melanoma cells is due to ubiquitination and subsequent proteasomal degradation and prevents MST2-mediated apoptosis.
FKBP4 regulates 5-fluorouracil sensitivity in colon cancer by controlling mitochondrial respirationFKBP4 controls mitochondrial respiration via modulating COA6-mediated biogenesis and activity of mitochondrial complex IV, thereby regulating 5-fluorouracil sensitivity in colon cancer.
PFKFB4 interacts with ICMT and activates RAS/AKT signaling-dependent cell migration in melanomaGlycolysis regulator PFKFB4 promotes cell migration in metastatic melanoma and normal melanocytes by a non-conventional glycolysis-independent function involving ICMT, RAS, and AKT signaling.
ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1As a mechanism of crosstalk, potentially relevant to cancer and developmental signaling, ERK2 MAP kinase phosphorylates the Hedgehog-pathway transcription factor GLI1 on three sites, promoting release of the negative regulator SUFU and the consequent activation of GLI1.