Cancer
- FKBP4 regulates 5-fluorouracil sensitivity in colon cancer by controlling mitochondrial respiration
FKBP4 controls mitochondrial respiration via modulating COA6-mediated biogenesis and activity of mitochondrial complex IV, thereby regulating 5-fluorouracil sensitivity in colon cancer.
- PFKFB4 interacts with ICMT and activates RAS/AKT signaling-dependent cell migration in melanoma
Glycolysis regulator PFKFB4 promotes cell migration in metastatic melanoma and normal melanocytes by a non-conventional glycolysis-independent function involving ICMT, RAS, and AKT signaling.
- ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1
As a mechanism of crosstalk, potentially relevant to cancer and developmental signaling, ERK2 MAP kinase phosphorylates the Hedgehog-pathway transcription factor GLI1 on three sites, promoting release of the negative regulator SUFU and the consequent activation of GLI1.
- PVT1 is a stress-responsive lncRNA that drives ovarian cancer metastasis and chemoresistance
PVT1 is a YAP1 dependent stress responsive lncRNA that promotes ovarian cancer metastasis and chemoresistance, making PVT1 a promising therapeutic target.
- KIF24 depletion induces clustering of supernumerary centrosomes in PDAC cells
Depletion of the centrosomal kinesin KIF24, known to restrain the assembly of primary cilia, suppresses multipolar spindle formation by clustering centrosomes in centrosome-amplified PDAC cells.
- STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer
Using a dual recombinase mouse model of pancreatic cancer, investigators uncover genetic evidence for the role of STAT3 signaling in cancer-associated fibroblasts in promoting tumor progression and an immunosuppressive microenvironment.
- Proteins implicated in muscular dystrophy and cancer are functional constituents of the centrosome
This study demonstrates that the muscular dystrophy-associated proteins dystrophin, utrophin, dysferlin, and calpain-3 localize to the centrosome and that their absence leads to excess centrosomes, compromised nuclear morphology, impaired centrosome orientation, and defective microtubule nucleation.
- chromMAGMA: regulatory element-centric interrogation of risk variants
chromMAGMA, a pipeline that prioritizes candidate risk regulatory elements and target genes, reveals novel risk-associated genes when applied to epithelial ovarian cancer.
- Estimating intraclonal heterogeneity and subpopulation changes from bulk expression profiles in CMap
Premnas is a computational framework that provides a new perspective to interpret perturbational data in LINC L1000 CMap by learning an ad hoc subpopulation representation from scRNA-seq and performing the digital cytometry to estimate the abundance of undetermined subpopulations.