Cancer
An OMA1 redox site controls mitochondrial homeostasis, sarcoma growth, and immunogenicityThis work describes how a mutation affecting mitochondrial metabolism in a sarcoma model induces protective immunity against the tumor and how this result might be relevant for sarcoma patients.
Endemic Burkitt lymphoma avatar mouse models for exploring inter-patient tumor variation and testing targeted therapiesPatient-derived tumor models show promise for evaluating novel cancer treatments that could improve outcomes for African children diagnosed with EBV-associated endemic Burkitt lymphoma.
RAS and PP2A activities converge on epigenetic gene regulationThis study reveals a hidden regulatory layer in epigenetic gene expression in cancer by co-operative phosphoregulation by RAS and tumor suppressor phosphatase PP2A.
Three-dimensional growth reveals fine-tuning of 5-lipoxygenase by proliferative pathways in cancerThe expression of 5-lipoxygenase, the key enzyme in leukotriene biosynthesis, is suppressed in proliferating cancer cells by a PI3K/mTORC-2– and MEK-1/ERK-dependent axis involving E2F1 and b-Myb.
AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradationThis study shows that TPX2 co-overexpression in non-transformed human cells induces AurkA nuclear accumulation and promotes its non-mitotic oncogenic functions.
Inflammasome-independent NLRP3 function enforces ATM activity in response to genotoxic stressThis study reports that NLRP3 is down-regulated in cancers and identifies a novel non-immune function for NLRP3 in maintaining genome integrity through the control of ATM activation in response to DSB.
Loss of dyskerin facilitates the acquisition of metastatic traits by altering the mevalonate pathwayCholesterol metabolism may be involved in the early steps of tumor dissemination. Epigenetic regulation of cholesterol synthesis and uptake is of great importance in this process and may constitute a vulnerability of the cancer cell that could be exploited pharmacologically.
Multi-level interaction between HIF and AHR transcriptional pathways in kidney carcinomaThis pan-genomic study of crosstalk between HIF and AHR transcription factors reveals both antagonistic and cooperative interactions and highlights their relevance to kidney cancer and its treatment.
Ectopic CH60 mediates HAPLN1-induced cell survival signaling in multiple myelomaThis study defines ectopic mitochondrial chaperonin 60 (CH60) on the multiple myeloma cell surface as a HAPLN1 matrikine receptor that signals via TLR4 to induce NF-κB signaling and drug resistance.
SLAMF6 compartmentalization enhances T cell functionsAfter stimulation, the T cell co-receptor SLAMF6 colocalizes with the TCR–CD3 complex to enhance T cell activation. Targeting SLAMF6 localization and function with bispecific antibodies is a novel mechanism with potential therapeutic translation.