Cancer
- Synergistic effect of antagonists to KRas4B/PDE6 molecular complex in pancreatic cancer
C14 and P8 combo reveals potent synergy in PDAC models, promising safer, effective therapy than gemcitabine.
- MUC13 drives cancer aggressiveness and metastasis through the YAP1-dependent pathway
This study reveals that MUC13 plays a critical role in the metastasis-associated processes via interaction with YAP1 and nuclear translocation of the YAP1-mediated survival complex and a biochemical intervention that interferes with MUC13–YAP1 complex formation can help develop new therapeutics.
- KCNQ potassium channels modulate Wnt activity in gastro-oesophageal adenocarcinomas
KCNQ3, a potassium channel, is frequently genetically altered in gastro-oesophageal adenocarcinomas and found to be significantly associated with WNT and MYC activity, and cellular proliferation.
- Glioblastoma cellular MAP4K1 facilitates tumor growth and disrupts T effector cell infiltration
MAP4K1 acts as a cancer cell-intrinsic driver of tumorigenesis and immune evasion in human gliomas, specifically glioblastoma multiforme, by modulating cytokine–chemokine signaling networks.
- RB loss sensitizes cells to replication-associated DNA damage after PARP inhibition by trapping
After PARP inhibition by trapping, cells lacking the RB tumor suppressor experience persistent replication stress and genomic instability that compromise cell viability.
- Comprehensive analysis of the lysine succinylome in fish oil-treated prostate cancer cells
Through a global lysine succinylation analysis of prostate cancer cells treated with fish oil, a significant number of lysine succinylation sites have been identified and FO-dependent GOT2 succinylation status may have a potential to inhibit building block generation.
- A new ferrocene derivative blocks K-Ras localization and function by oxidative modification at His95
We report redox system regulates KRAS localization and activity via oxidation at His95 residue, and proposes a role of oncogenic K-Ras in the antioxidant-induced growth and metastasis of KRAS-driven cancers.
- LEF1 enhances β-catenin transactivation through IDR-dependent liquid–liquid phase separation
This research elucidates the correlation between liquid–liquid phase separation (LLPS) of LEF1 with β-catenin and their transcriptional activation function, offering a novel therapeutic approach for the treatment of colorectal cancer through LLPS.
- Decoding the obesity–cancer connection: lessons from preclinical models of pancreatic adenocarcinoma
Preclinical models demonstrate that obesity reprograms the pretumor or tumor cell and its micro- and macro-environments to drive cancer development via altered cellular metabolism, hormone dysregulation, inflammation, and microbial dysbiosis.
- Polo-like kinase-1 mediates hepatitis C virus-induced cell migration, a drug target for liver cancer
This study identifies PLK1 as a novel protein that promotes liver cancer in people with hepatitis C. The findings suggest a novel drug target for patients with liver cancer to reduce cancer spread and improve survival.