Cancer
ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1As a mechanism of crosstalk, potentially relevant to cancer and developmental signaling, ERK2 MAP kinase phosphorylates the Hedgehog-pathway transcription factor GLI1 on three sites, promoting release of the negative regulator SUFU and the consequent activation of GLI1.
PVT1 is a stress-responsive lncRNA that drives ovarian cancer metastasis and chemoresistancePVT1 is a YAP1 dependent stress responsive lncRNA that promotes ovarian cancer metastasis and chemoresistance, making PVT1 a promising therapeutic target.
KIF24 depletion induces clustering of supernumerary centrosomes in PDAC cellsDepletion of the centrosomal kinesin KIF24, known to restrain the assembly of primary cilia, suppresses multipolar spindle formation by clustering centrosomes in centrosome-amplified PDAC cells.
STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancerUsing a dual recombinase mouse model of pancreatic cancer, investigators uncover genetic evidence for the role of STAT3 signaling in cancer-associated fibroblasts in promoting tumor progression and an immunosuppressive microenvironment.
Proteins implicated in muscular dystrophy and cancer are functional constituents of the centrosomeThis study demonstrates that the muscular dystrophy-associated proteins dystrophin, utrophin, dysferlin, and calpain-3 localize to the centrosome and that their absence leads to excess centrosomes, compromised nuclear morphology, impaired centrosome orientation, and defective microtubule nucleation.
chromMAGMA: regulatory element-centric interrogation of risk variantschromMAGMA, a pipeline that prioritizes candidate risk regulatory elements and target genes, reveals novel risk-associated genes when applied to epithelial ovarian cancer.
Estimating intraclonal heterogeneity and subpopulation changes from bulk expression profiles in CMapPremnas is a computational framework that provides a new perspective to interpret perturbational data in LINC L1000 CMap by learning an ad hoc subpopulation representation from scRNA-seq and performing the digital cytometry to estimate the abundance of undetermined subpopulations.
Workflow for high-dimensional flow cytometry analysis of T cells from tumor metastasesWe describe an improved method for the high-dimensional flow cytometry analysis of conventional and rare unconventional T cells infiltrating tumor liver metastases.
MET∆14 promotes a ligand-dependent, AKT-driven invasive growthThe MET oncogene’s most frequent mutation is exon14 deletion. The resulting MET∆14 kinase is not constitutively active but requires HGF. The response to the ligand is stronger and long-lasting, protecting cancer cells from apoptosis and driving invasive growth.