Cancer
Synergistic effect of antagonists to KRas4B/PDE6 molecular complex in pancreatic cancerC14 and P8 combo reveals potent synergy in PDAC models, promising safer, effective therapy than gemcitabine.
MUC13 drives cancer aggressiveness and metastasis through the YAP1-dependent pathwayThis study reveals that MUC13 plays a critical role in the metastasis-associated processes via interaction with YAP1 and nuclear translocation of the YAP1-mediated survival complex and a biochemical intervention that interferes with MUC13–YAP1 complex formation can help develop new therapeutics.
KCNQ potassium channels modulate Wnt activity in gastro-oesophageal adenocarcinomasKCNQ3, a potassium channel, is frequently genetically altered in gastro-oesophageal adenocarcinomas and found to be significantly associated with WNT and MYC activity, and cellular proliferation.
Glioblastoma cellular MAP4K1 facilitates tumor growth and disrupts T effector cell infiltrationMAP4K1 acts as a cancer cell-intrinsic driver of tumorigenesis and immune evasion in human gliomas, specifically glioblastoma multiforme, by modulating cytokine–chemokine signaling networks.
RB loss sensitizes cells to replication-associated DNA damage after PARP inhibition by trappingAfter PARP inhibition by trapping, cells lacking the RB tumor suppressor experience persistent replication stress and genomic instability that compromise cell viability.
Comprehensive analysis of the lysine succinylome in fish oil-treated prostate cancer cellsThrough a global lysine succinylation analysis of prostate cancer cells treated with fish oil, a significant number of lysine succinylation sites have been identified and FO-dependent GOT2 succinylation status may have a potential to inhibit building block generation.
A new ferrocene derivative blocks K-Ras localization and function by oxidative modification at His95We report redox system regulates KRAS localization and activity via oxidation at His95 residue, and proposes a role of oncogenic K-Ras in the antioxidant-induced growth and metastasis of KRAS-driven cancers.
LEF1 enhances β-catenin transactivation through IDR-dependent liquid–liquid phase separationThis research elucidates the correlation between liquid–liquid phase separation (LLPS) of LEF1 with β-catenin and their transcriptional activation function, offering a novel therapeutic approach for the treatment of colorectal cancer through LLPS.
Decoding the obesity–cancer connection: lessons from preclinical models of pancreatic adenocarcinomaPreclinical models demonstrate that obesity reprograms the pretumor or tumor cell and its micro- and macro-environments to drive cancer development via altered cellular metabolism, hormone dysregulation, inflammation, and microbial dysbiosis.
Polo-like kinase-1 mediates hepatitis C virus-induced cell migration, a drug target for liver cancerThis study identifies PLK1 as a novel protein that promotes liver cancer in people with hepatitis C. The findings suggest a novel drug target for patients with liver cancer to reduce cancer spread and improve survival.