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Cancer

  • Stromal fibroblasts induce metastatic tumor cell clusters via epithelial–mesenchymal plasticity
    Open Access
    Stromal fibroblasts induce metastatic tumor cell clusters via epithelial–mesenchymal plasticity

    Yuko Matsumura, Yasuhiko Ito, Yoshihiro Mezawa, Kaidiliayi Sulidan, Yataro Daigo, Toru Hiraga, Kaoru Mogushi, Nadila Wali, Hiromu Suzuki, Takumi Itoh, Yohei Miyagi, Tomoyuki Yokose, Satoru Shimizu, Atsushi Takano, Yasuhisa Terao, Harumi Saeki, Masayuki Ozawa, Masaaki Abe, Satoru Takeda, Ko Okumura, Sonoko Habu, Okio Hino, Kazuyoshi Takeda, Michiaki Hamada, Akira Orimo

    Yuko Matsumura ... Akira Orimo

    Published 22 July 2019

    This study highlights the cellular and molecular mechanisms by which stromal fibroblasts enable human breast cancer cells to form tumor cell clusters and acquire highly invasive and metastatic traits.

  • De novo prediction of cell-type complexity in single-cell RNA-seq and tumor microenvironments
    Open Access
    De novo prediction of cell-type complexity in single-cell RNA-seq and tumor microenvironments

    Jun Woo, Boris J. Winterhoff, Timothy K. Starr, Constantin Aliferis, Jinhua Wang

    Jun Woo ... Jinhua Wang

    Published 2 July 2019

    This study describes a computational method for determining statistical support to varying levels of heterogeneity provided by single-cell RNA-sequencing data with applications to tumor samples.

  • The cancer cell proteome and transcriptome predicts sensitivity to targeted and cytotoxic drugs
    Open Access
    The cancer cell proteome and transcriptome predicts sensitivity to targeted and cytotoxic drugs

    Mattias Rydenfelt, Matthew Wongchenko, Bertram Klinger, Yibing Yan, Nils Blüthgen

    Mattias Rydenfelt ... Nils Blüthgen

    Published 28 June 2019

    This study shows that the proteomic and transcriptomic states of cancer cells are more predictive of drug sensitivity than genomic markers for most drugs, both within and across tumor types.

  • Human organotypic brain slice culture: a novel framework for environmental research in neuro-oncology
    Open Access
    Human organotypic brain slice culture: a novel framework for environmental research in neuro-oncology

    Vidhya M Ravi, Kevin Joseph, Julian Wurm, Simon Behringer, Nicklas Garrelfs, Paolo d’Errico, Yashar Naseri, Pamela Franco, Melanie Meyer-Luehmann, Roman Sankowski, Mukesch Johannes Shah, Irina Mader, Daniel Delev, Marie Follo, Jürgen Beck, Oliver Schnell, Ulrich G Hofmann, Dieter Henrik Heiland

    Vidhya M Ravi ... Dieter Henrik Heiland

    Published 27 June 2019

    Therapeutically resected, adult brain segments were maintained and characterized for an extended period to study glioblastoma progression and treatment in its almost natural environment.

  • Inhibition of host NOX1 blocks tumor growth and enhances checkpoint inhibitor–based immunotherapy
    Open Access
    Inhibition of host NOX1 blocks tumor growth and enhances checkpoint inhibitor–based immunotherapy

    Jimmy Stalin, Sarah Garrido-Urbani, Freddy Heitz, Cédric Szyndralewiez, Stephane Jemelin, Oriana Coquoz, Curzio Ruegg, Beat A Imhof

    Jimmy Stalin ... Beat A Imhof

    Published 27 June 2019

    Blocking NOX1 with the novel small molecule inhibitor GKT771 inhibits tumor growth in mice by targeting tumor lymph/angiogenesis and promoting antitumor immune cells recruitment. GKT771 emerges as a novel and promising anticancer drug worth translating into the clinics.

  • Mesenchymal stromal cell activation by breast cancer secretomes in bioengineered 3D microenvironments
    Open Access
    Mesenchymal stromal cell activation by breast cancer secretomes in bioengineered 3D microenvironments

    Ulrich Blache, Edward R Horton, Tian Xia, Erwin M Schoof, Lene H Blicher, Angelina Schönenberger, Jess G Snedeker, Ivan Martin, Janine T Erler, Martin Ehrbar

    Ulrich Blache ... Martin Ehrbar

    Published 3 June 2019

    This study shows the activation of tumour-associated mesenchymal stromal cells by breast cancer secretomes in bioengineered 3D microenvironments using comprehensive multiomics analysis methods.

  • Tumor-intrinsic response to IFNγ shapes the tumor microenvironment and anti–PD-1 response in NSCLC
    Open Access
    Tumor-intrinsic response to IFNγ shapes the tumor microenvironment and anti–PD-1 response in NSCLC

    Bonnie L Bullock, Abigail K Kimball, Joanna M Poczobutt, Alexander J Neuwelt, Howard Y Li, Amber M Johnson, Jeff W Kwak, Emily K Kleczko, Rachael E Kaspar, Emily K Wagner, Katharina Hopp, Erin L Schenk, Mary CM Weiser-Evans, Eric T Clambey, Raphael A Nemenoff

    Bonnie L Bullock ... Raphael A Nemenoff

    Published 27 May 2019

    Using an immunocompetent mouse model of NSCLC, this study demonstrates that tumor-intrinsic response to IFNγ determines response to anti–PD-1 through alterations in the tumor microenvironment.

  • A network of human functional gene interactions from knockout fitness screens in cancer cells
    Open Access
    A network of human functional gene interactions from knockout fitness screens in cancer cells

    Eiru Kim, Merve Dede, Walter F Lenoir, Gang Wang, Sanjana Srinivasan, Medina Colic, Traver Hart

    Eiru Kim ... Traver Hart

    Published 12 April 2019

    The function of human genes can be strongly inferred from their knockout fitness profiles across hundreds of CRISPR screens, illuminating the modular organization of the cell.

  • The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner
    Open Access
    The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner

    Alexander Martin Heberle, Patricia Razquin Navas, Miriam Langelaar-Makkinje, Katharina Kasack, Ahmed Sadik, Erik Faessler, Udo Hahn, Philip Marx-Stoelting, Christiane A Opitz, Christine Sers, Ines Heiland, Sascha Schäuble, Kathrin Thedieck

    Alexander Martin Heberle ... Kathrin Thedieck

    Published 28 March 2019

    PI3K and p38 act in a hierarchical manner to enhance mTORC1 activity and stress granule formation; although PI3K is the main driver, the impact of p38 gets apparent as PI3K activity declines.

  • Gene editing enables T-cell engineering to redirect antigen specificity for potent tumor rejection
    Open Access
    Gene editing enables T-cell engineering to redirect antigen specificity for potent tumor rejection

    Julian J Albers, Tim Ammon, Dario Gosmann, Stefan Audehm, Silvia Thoene, Christof Winter, Ramona Secci, Anja Wolf, Anja Stelzl, Katja Steiger, Jürgen Ruland, Florian Bassermann, Christian Kupatt, Martina Anton, Angela M Krackhardt

    Julian J Albers ... Angela M Krackhardt

    Published 15 March 2019

    Targeted integration of a tumor-reactive T-cell receptor into the TRAC locus using CRISPR-Cas9 and AAV6 redirects primary human T cells against tumor cells in vitro and in vivo.

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