Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Methods & Resources
    • Author Interviews
    • Archive
    • Subjects
  • Collections
  • Submit
    • Submit a Manuscript
    • Author Guidelines
    • License, Copyright, Fee
    • FAQ
    • Why submit
  • About
    • About Us
    • Editors & Staff
    • Board Members
    • Licensing and Reuse
    • Reviewer Guidelines
    • Privacy Policy
    • Advertise
    • Contact Us
    • LSA LLC
  • Alerts
  • Other Publications
    • EMBO Press
    • The EMBO Journal
    • EMBO reports
    • EMBO Molecular Medicine
    • Molecular Systems Biology
    • Rockefeller University Press
    • Journal of Cell Biology
    • Journal of Experimental Medicine
    • Journal of General Physiology
    • Journal of Human Immunity
    • Cold Spring Harbor Laboratory Press
    • Genes & Development
    • Genome Research

User menu

  • My alerts

Search

  • Advanced search
Life Science Alliance
  • Other Publications
    • EMBO Press
    • The EMBO Journal
    • EMBO reports
    • EMBO Molecular Medicine
    • Molecular Systems Biology
    • Rockefeller University Press
    • Journal of Cell Biology
    • Journal of Experimental Medicine
    • Journal of General Physiology
    • Journal of Human Immunity
    • Cold Spring Harbor Laboratory Press
    • Genes & Development
    • Genome Research
  • My alerts
Life Science Alliance

Advanced Search

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Methods & Resources
    • Author Interviews
    • Archive
    • Subjects
  • Collections
  • Submit
    • Submit a Manuscript
    • Author Guidelines
    • License, Copyright, Fee
    • FAQ
    • Why submit
  • About
    • About Us
    • Editors & Staff
    • Board Members
    • Licensing and Reuse
    • Reviewer Guidelines
    • Privacy Policy
    • Advertise
    • Contact Us
    • LSA LLC
  • Alerts
  • Follow LSA on Bluesky
  • Follow lsa Template on Twitter

Cancer

  • C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosis
    Open Access
    C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosis

    Melissa R Perrino, Niousha Ahmari, Ashley Hall, Mark Jackson, Youjin Na, Jay Pundavela, Sara Szabo, Trent M Woodruff, Eva Dombi, Mi-Ok Kim, Jörg Köhl, Jianqiang Wu, Nancy Ratner

    Melissa R Perrino ... Nancy Ratner

    Published 8 March 2024

    C5aR antagonist and MEK inhibition combination therapy changes the tumor microenvironment and induces ongoing tumor cell phagocytosis.

  • Oncogenic mutations of KRAS modulate its turnover by the CUL3/LZTR1 E3 ligase complex
    Open Access
    Oncogenic mutations of KRAS modulate its turnover by the CUL3/LZTR1 E3 ligase complex

    Andreas Damianou, Zhu Liang, Frederik Lassen, Iolanda Vendrell, George Vere, Svenja Hester, Philip D Charles, Adan Pinto-Fernandez, Alberto Santos, Roman Fischer, Benedikt M Kessler

    Andreas Damianou ... Benedikt M Kessler

    Published 7 March 2024

    The study reveals how KRAS mutations disrupt LZTR1-mediated KRAS degradation, shedding light on potential mechanisms in oncogenesis.

  • Genome-wide CRISPR screen reveals the synthetic lethality between BCL2L1 inhibition and radiotherapy
    Open Access
    Genome-wide CRISPR screen reveals the synthetic lethality between BCL2L1 inhibition and radiotherapy

    Ling Yin, Xiaoding Hu, Guangsheng Pei, Mengfan Tang, You Zhou, Huimin Zhang, Min Huang, Siting Li, Jie Zhang, Citu Citu, Zhongming Zhao, Bisrat G Debeb, Xu Feng, Junjie Chen

    Ling Yin ... Junjie Chen

    Published 5 February 2024

    Unbiased whole-genome CRISPR/Cas9 screening reveals that loss of BCL2L1 shows synthetic lethality with radiation, which is further confirmed with the use of BCL2L1 inhibitor. Thus, radiation plus inhibitors targeting BCL2 family proteins is a promising combination therapy for cancers.

  • NeoMUST: an accurate and efficient multi-task learning model for neoantigen presentation
    Open Access
    NeoMUST: an accurate and efficient multi-task learning model for neoantigen presentation

    Wang Ma, Jiawei Zhang, Hui Yao

    Wang Ma ... Hui Yao

    Published 30 January 2024

    NeoMUST, a multi-task learning model, efficiently predicts neoantigen presentation via MHC-I molecules, rivaling existing algorithms with significantly shorter training time. Its GitHub repository offers free access for advancing cancer immunotherapy development.

  • Nucleolar protein TAAP1/<em>C22orf46</em> confers pro-survival signaling in non-small cell lung cancer
    Open Access
    Nucleolar protein TAAP1/C22orf46 confers pro-survival signaling in non-small cell lung cancer

    Marietta Döring, Melanie Brux, Maciej Paszkowski-Rogacz, Pedro M Guillem-Gloria, Frank Buchholz, M Teresa Pisabarro, Mirko Theis

    Marietta Döring ... Mirko Theis

    Published 16 January 2024

    CRISPR/Cas9 screening identifies the gene C22orf46 to counteract pro-apoptotic signals provided by T cells or anti-neoplastic drugs and contributes to tumorigenesis.

  • VE-cadherin junction dynamics in initial lymphatic vessels promotes lymph node metastasis
    Open Access
    VE-cadherin junction dynamics in initial lymphatic vessels promotes lymph node metastasis

    Miguel Sáinz-Jaspeado, Sarah Ring, Steven T Proulx, Mark Richards, Pernilla Martinsson, Xiujuan Li, Lena Claesson-Welsh, Maria H Ulvmar, Yi Jin

    Miguel Sáinz-Jaspeado ... Yi Jin

    Published 26 December 2023

    Exposure of initial dermal lymphatics to VEGFA or a tumor results in zippering of VE-cadherin at junctions, concomitant with Src-dependent VE-cadherin fragmentation.

  • Loss-of-function cancer-linked mutations in the EIF4G2 non-canonical translation initiation factor
    Open Access
    Loss-of-function cancer-linked mutations in the EIF4G2 non-canonical translation initiation factor

    Sara Meril, Marcela Bahlsen, Miriam Eisenstein, Alon Savidor, Yishai Levin, Shani Bialik, Shmuel Pietrokovski, Adi Kimchi

    Sara Meril ... Adi Kimchi

    Published 21 December 2023

    This work identifies missense mutations in the translation initiation factor EIF4G2 gene in cancer, showing loss-of-function effects on binding to interacting proteins and translational activity.

  • Correction: LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug
    Open Access
    Correction: LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug

    Valentina Cutano, Jessica Marianne Ferreira Mendes, Sara Escudeiro-Lopes, Susana Machado, Judith Vinaixa Forner, Juan M Gonzales-Morena, Martin Prevorovsky, Viacheslav Zemlianski, Yuxiong Feng, Petra Kralova Viziova, Andrea Hartmanova, Beata Malcekova, Pavel Jakoube, Sonia Iyer, Zuzana Keckesova

    Valentina Cutano ... Zuzana Keckesova

    Published 6 December 2023

    We show the ability of LACTB to function as a tumor suppressor in ovarian cancer through down-regulation of Slug and induction of differentiation.

  • Proteomic-based stratification of intermediate-risk prostate cancer patients
    Open Access
    Proteomic-based stratification of intermediate-risk prostate cancer patients

    Qing Zhong, Rui Sun, Adel T Aref, Zainab Noor, Asim Anees, Yi Zhu, Natasha Lucas, Rebecca C Poulos, Mengge Lyu, Tiansheng Zhu, Guo-Bo Chen, Yingrui Wang, Xuan Ding, Dorothea Rutishauser, Niels J Rupp, Jan H Rueschoff, Cédric Poyet, Thomas Hermanns, Christian Fankhauser, María Rodríguez Martínez, Wenguang Shao, Marija Buljan, Janis Frederick Neumann, Andreas Beyer, Peter G Hains, Roger R Reddel, Phillip J Robinson, Ruedi Aebersold, Tiannan Guo, Peter J Wild

    Qing Zhong ... Peter J Wild

    Published 4 December 2023

    This study demonstrates the ability of a protein-based signature to risk-stratify prostate cancer patients with Gleason grade groups 2 and 3 and predict the risk of biochemical recurrence.

  • Analysis of the indispensable RAD51 cofactor BRCA2 in <em>Naganishia liquefaciens</em>, a Basidiomycota yeast
    Open Access
    Analysis of the indispensable RAD51 cofactor BRCA2 in Naganishia liquefaciens, a Basidiomycota yeast

    Maierdan Palihati, Hiroshi Iwasaki, Hideo Tsubouchi

    Maierdan Palihati ... Hideo Tsubouchi

    Published 28 November 2023

    Identification of the BRCA2 homolog in the Basidiomycota yeast Naganishia liquefaciens reveals the general attributes of fungal BRCA2 and its essential role in Rad51-mediated homologous recombination.

Pages

  • Previous
  • Next
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 7
  • 8
  • 9
  • …
  • 24
  • Aging (33)
  • Biophysics (53)
  • Cancer (235)
  • Cell Biology (585)
  • Chemical Biology (23)
  • Chromatin & Epigenetics (133)
  • Development (123)
  • Ecology (5)
  • Evolution (35)
  • Genetics, Gene Therapy & Genetic Disease (130)
  • Genomics & Functional Genomics (167)
  • Immunology (217)
  • Medical Research (98)
  • Metabolism (104)
  • Methods & Resources (89)
  • Microbiology, Virology & Host Pathogen Interaction (157)
  • Molecular Biology (325)
  • Molecular Diagnostics & Diagnostic Imaging (12)
  • Neuroscience (155)
  • Pharmacology & Biotechnology (17)
  • Physiology (45)
  • Plant Science (26)
  • Stem Cells (71)
  • Structural Biology (85)
  • Synthetic Biology (6)
  • Systems & Computational Biology (125)
Advertisement

EMBO Press LogoRockefeller University Press LogoCold Spring Harbor Logo

Content

  • Home
  • Newest Articles
  • Current Issue
  • Archive
  • Subject Collections

For Authors

  • Submit a Manuscript
  • Author Guidelines
  • License, copyright, Fee

Other Services

  • Alerts
  • Bluesky
  • X/Twitter
  • RSS Feeds

More Information

  • Editors & Staff
  • Reviewer Guidelines
  • Feedback
  • Licensing and Reuse
  • Privacy Policy

ISSN: 2575-1077
© 2025 Life Science Alliance LLC

Life Science Alliance is registered as a trademark in the U.S. Patent and Trade Mark Office and in the European Union Intellectual Property Office.