Cancer
- Exploring the impact of dexamethasone on gene regulation in myeloma cells
The study uncovers epigenomic changes associated with dexamethasone response heterogeneity in myeloma cells, revealing rewired promoter–enhancer interactions and DNA loop stabilization.
- Regulation of hPCL3 isoforms’ ubiquitination by TRIM21 in non-small cell lung cancer progression
hPCL3 isoforms, hPCL3S and hPCL3L, are studied in NSCLC. Elevated expression of both isoforms correlates with poor survival. Inhibiting hPCL3S reduces cell growth, invasion, and migration, suggesting it as a potential therapeutic target.
- PASCAR: a multiscale framework to explore the design space of constitutive and inducible CAR T cells
An experimentally validated protein abundance structured population dynamic model for CAR T cells (PASCAR) that integrates processes from molecules to single cells to cell populations and systematically explores the design space of constitutive and tunable CAR T cells.
- Full-length transcript alterations in human bronchial epithelial cells with U2AF1 S34F mutations
Using long-read Nanopore cDNA sequencing, this study identifies full-length transcripts associated with U2AF1 S34F mutations revealing effects on translation regulation of specific genes.
- Extracellular matrix sensing via modulation of orientational order of integrins and F-actin in focal adhesions
Using fluorescence polarisation microscopy and computational modeling, we find that FA molecules exhibit ECM dependent orientational co-alignment or order. This molecular organizational property in addition to nanoscale localization may explain precise and sensitive decoding of ECM cues.
- AR activates YAP/TAZ differentially in prostate cancer
We show YAP and TAZ are differentially activated upon androgen stimulation. Through genetic targeting of YAP, we show that YAP drives the ability for anchorage independent growth and find that YAP/TAZ is not essential for AR signalling.
- A network embedding approach to identify active modules in biological interaction networks
This study proposes the AMINE method as a flexible and efficient approach to identify active modules from a data embedding combining gene expression and interaction data.
- CNN2 silencing inhibits colorectal cancer development through promoting ubiquitination of EGR1
In colorectal cancer (CRC), CNN2 was found to form a complex with YAP1 and EGR1, thus regulating EGR1 expression and promoting CRC, which could be considered as a potential therapeutic target for CRC.
- Antibody reliability influences observed mRNA–protein correlations in tumour samples
Upadhya and Ryan show that the reliability of antibodies used for RPPA profiling influences the mRNA-protein correlations observed in tumour cohorts.
- The C-type lectin domain of CD62P (P-selectin) functions as an integrin ligand
The lectin domain of CD62P specifically binds to and activates integrins. CD62P-integrin interactions may function in a diverse set of cell–cell adhesions given that integrins are widely expressed.