Cancer
C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosisC5aR antagonist and MEK inhibition combination therapy changes the tumor microenvironment and induces ongoing tumor cell phagocytosis.
Oncogenic mutations of KRAS modulate its turnover by the CUL3/LZTR1 E3 ligase complexThe study reveals how KRAS mutations disrupt LZTR1-mediated KRAS degradation, shedding light on potential mechanisms in oncogenesis.
Genome-wide CRISPR screen reveals the synthetic lethality between BCL2L1 inhibition and radiotherapyUnbiased whole-genome CRISPR/Cas9 screening reveals that loss of BCL2L1 shows synthetic lethality with radiation, which is further confirmed with the use of BCL2L1 inhibitor. Thus, radiation plus inhibitors targeting BCL2 family proteins is a promising combination therapy for cancers.
NeoMUST: an accurate and efficient multi-task learning model for neoantigen presentationNeoMUST, a multi-task learning model, efficiently predicts neoantigen presentation via MHC-I molecules, rivaling existing algorithms with significantly shorter training time. Its GitHub repository offers free access for advancing cancer immunotherapy development.
Nucleolar protein TAAP1/C22orf46 confers pro-survival signaling in non-small cell lung cancerCRISPR/Cas9 screening identifies the gene C22orf46 to counteract pro-apoptotic signals provided by T cells or anti-neoplastic drugs and contributes to tumorigenesis.
VE-cadherin junction dynamics in initial lymphatic vessels promotes lymph node metastasisExposure of initial dermal lymphatics to VEGFA or a tumor results in zippering of VE-cadherin at junctions, concomitant with Src-dependent VE-cadherin fragmentation.
Loss-of-function cancer-linked mutations in the EIF4G2 non-canonical translation initiation factorThis work identifies missense mutations in the translation initiation factor EIF4G2 gene in cancer, showing loss-of-function effects on binding to interacting proteins and translational activity.
Correction: LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of SlugWe show the ability of LACTB to function as a tumor suppressor in ovarian cancer through down-regulation of Slug and induction of differentiation.
Proteomic-based stratification of intermediate-risk prostate cancer patientsThis study demonstrates the ability of a protein-based signature to risk-stratify prostate cancer patients with Gleason grade groups 2 and 3 and predict the risk of biochemical recurrence.
Analysis of the indispensable RAD51 cofactor BRCA2 in Naganishia liquefaciens, a Basidiomycota yeastIdentification of the BRCA2 homolog in the Basidiomycota yeast Naganishia liquefaciens reveals the general attributes of fungal BRCA2 and its essential role in Rad51-mediated homologous recombination.