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Cancer

  • CHUK/IKK-α loss in lung epithelial cells enhances NSCLC growth associated with HIF up-regulation
    Open Access
    CHUK/IKK-α loss in lung epithelial cells enhances NSCLC growth associated with HIF up-regulation

    Evangelia Chavdoula, David M Habiel, Eugenia Roupakia, Georgios S Markopoulos, Eleni Vasilaki, Antonis Kokkalis, Alexander P Polyzos, Haralabia Boleti, Dimitris Thanos, Apostolos Klinakis, Evangelos Kolettas, Kenneth B Marcu

    Evangelia Chavdoula ... Kenneth B Marcu

    Published 2 December 2019

    IKKα is an NSCLC suppressor and its loss in mouse AT-II lung epithelial cells or in human NSCLC lines increased urethane-induced adenoma growth and xenograft burdens, respectively. IKKα loss can up-regulate HIF-1α, enhancing tumor growth under hypoxia.

  • Evaluation of colorectal cancer subtypes and cell lines using deep learning
    Open Access
    Evaluation of colorectal cancer subtypes and cell lines using deep learning

    Jonathan Ronen, Sikander Hayat, Altuna Akalin

    Jonathan Ronen ... Altuna Akalin

    Published 2 December 2019

    A deep learning approach refines the state-of-the-art subtypes of colorectal cancer and evaluates the fidelity of cell lines that model cancer.

  • Reference-free transcriptome exploration reveals novel RNAs for prostate cancer diagnosis
    Open Access
    Reference-free transcriptome exploration reveals novel RNAs for prostate cancer diagnosis

    Marina Pinskaya, Zohra Saci, Mélina Gallopin, Marc Gabriel, Ha TN Nguyen, Virginie Firlej, Marc Descrimes, Audrey Rapinat, David Gentien, Alexandre de la Taille, Arturo Londoño-Vallejo, Yves Allory, Daniel Gautheret, Antonin Morillon

    Marina Pinskaya ... Antonin Morillon

    Published 15 November 2019

    A reference-free computational workflow for the discovery of unannotated RNA biomarkers retrieves novel noncoding RNAs with high potential for prostate cancer diagnosis.

  • MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy
    Open Access
    MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy

    Mark Owyong, Jonathan Chou, Renske JE van den Bijgaart, Niwen Kong, Gizem Efe, Carrie Maynard, Dalit Talmi-Frank, Inna Solomonov, Charlotte Koopman, Elin Hadler-Olsen, Mark Headley, Charlene Lin, Chih-Yang Wang, Irit Sagi, Zena Werb, Vicki Plaks

    Mark Owyong ... Vicki Plaks

    Published 14 November 2019

    Inhibition of active MMP9 early during tumorigenesis suppresses tumor cell migration, invasion, and colony formation and tilts the balance towards anti-tumor immunity by activating CD8+ T cells.

  • TRAIL-induced variation of cell signaling states provides nonheritable resistance to apoptosis
    Open Access
    TRAIL-induced variation of cell signaling states provides nonheritable resistance to apoptosis

    Reema Baskar, Harris G Fienberg, Zumana Khair, Patricia Favaro, Sam Kimmey, Douglas R Green, Garry P Nolan, Sylvia Plevritis, Sean C Bendall

    Reema Baskar ... Sean C Bendall

    Published 8 November 2019

    This work summarizes cellular apoptotic and signaling response to TRAIL across 10 cell lines and for the first time links signaling diversity to nongenetic resistance. This high-dimensional, single-cell approach toward TRAIL resistance sets a standard in studying nongenetic resistance.

  • Drug-induced chromatin accessibility changes associate with sensitivity to liver tumor promotion
    Open Access
    Drug-induced chromatin accessibility changes associate with sensitivity to liver tumor promotion

    Antonio Vitobello, Juliane Perner, Johanna Beil, Jiang Zhu, Alberto Del Río-Espínola, Laurent Morawiec, Magdalena Westphal, Valérie Dubost, Marc Altorfer, Ulrike Naumann, Arne Mueller, Karen Kapur, Mark Borowsky, Colin Henderson, C Roland Wolf, Michael Schwarz, Jonathan Moggs, Rémi Terranova

    Antonio Vitobello ... Rémi Terranova

    Published 15 October 2019

    This work explores quantitative chromatin accessibility, transcriptional and cis-acting gene regulatory variations underlying mouse strain–specific differences in drug-induced liver tumor promotion sensitivity.

  • Targeting plasma membrane phosphatidylserine content to inhibit oncogenic KRAS function
    Open Access
    Targeting plasma membrane phosphatidylserine content to inhibit oncogenic KRAS function

    Walaa E Kattan, Wei Chen, Xiaoping Ma, Tien Hung Lan, Dharini van der Hoeven, Ransome van der Hoeven, John F Hancock

    Walaa E Kattan ... John F Hancock

    Published 26 August 2019

    KRAS-dependent cancer cell growth is inhibited by disrupting phosphatidylserine transport to the plasma membrane by genetic knockdown of lipid exchangers ORP5 and ORP8 or by inhibition of PI4KIIIα.

  • A molecule inducing androgen receptor degradation and selectively targeting prostate cancer cells
    Open Access
    A molecule inducing androgen receptor degradation and selectively targeting prostate cancer cells

    Serge Auvin, Harun Öztürk, Yusuf T Abaci, Gisele Mautino, Florence Meyer-Losic, Florence Jollivet, Tarig Bashir, Hugues de Thé, Umut Sahin

    Serge Auvin ... Umut Sahin

    Published 20 August 2019

    A new molecule induces AR sumoylation and degradation resulting in selective growth inhibition in AR-dependent prostate cancer cells, but its activity is blunted by interference with proteasomes.

  • GRP78 regulates CD44v membrane homeostasis and cell spreading in tamoxifen-resistant breast cancer
    Open Access
    GRP78 regulates CD44v membrane homeostasis and cell spreading in tamoxifen-resistant breast cancer

    Chun-Chih Tseng, Ramunas Stanciauskas, Pu Zhang, Dennis Woo, Kaijin Wu, Kevin Kelly, Parkash S Gill, Min Yu, Fabien Pinaud, Amy S Lee

    Chun-Chih Tseng ... Amy S Lee

    Published 15 August 2019

    Endoplasmic reticulum chaperone protein GRP78 interacts with CD44v and regulates F-actin integrity, cell adhesion, and cell spreading in breast cancer cells. Targeting cell surface GRP78 by antibodies can reduce CD44v expression.

  • The miRNA <em>bantam</em> regulates growth and tumorigenesis by repressing the cell cycle regulator <em>tribbles</em>
    Open Access
    The miRNA bantam regulates growth and tumorigenesis by repressing the cell cycle regulator tribbles

    Stephan U Gerlach, Moritz Sander, Shilin Song, Héctor Herranz

    Stephan U Gerlach ... Héctor Herranz

    Published 22 July 2019

    This work identifies the cell cycle regulator tribbles as a target of the miRNA bantam involved in the growth regulatory and oncogenic functions of bantam in Drosophila epithelia.

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