Cancer
WBP2 inhibits microRNA biogenesis via interaction with the microprocessor complexWBP2 protein blocks the microRNA biogenesis via physical interactions with the microprocessor complex, and reverts the tumor-suppressive role of DGCR8.
Multifaceted regulation of hepatic lipid metabolism by YY1This study shows that YY1 regulates hepatic lipid metabolism by directly or indirectly regulating the expression of several key upstream transcription factors and their coactivators.
Specific N-cadherin–dependent pathways drive human breast cancer dormancy in bone marrowCDH2 is required for connexin 43 (Cx43)–mediated gap junction intercellular communication between breast cancer cells and bone marrow niche cells to achieve dormancy and chemoresistance.
The transcriptional landscape analysis of basal cell carcinomas reveals novel signalling pathways and actionable targetsBasal cell carcinoma (BCC) is the most common skin cancer and human malignancy. By analyzing BCC RNA sequencing data according to clinically important features, we identified novel differentially regulated genes and new targetable pathways. Several biomarkers were validated in patient-derived BCC samples.
Mitochondrial Aurora kinase A induces mitophagy by interacting with MAP1LC3 and Prohibitin 2The multifunctional Ser/Thr kinase AURKA uses the Inner Mitochondrial Membrane receptor PHB2 and MAP1LC3 as a signalling platform to orchestrate the elimination of dysfunctional mitochondria.
The AXL-PYK2-PKCα axis as a nexus of stemness circuits in TNBCA clinically relevant AXL-PYK2-PKCα axis where PYK2 and PKCα act as signaling nodes and functionally cooperate to converge stemness promoting pathways and regulate Oct4 and Nanog pluripotent TFs.
Pancreatic cancer is marked by complement-high blood monocytes and tumor-associated macrophagesThis study uses biomaterial scaffolds to identify a macrophage gene signature defined by high expression of C1qa, C1qb, and Trem2 that is elevated systemically in mouse and human pancreatic cancer.
Cancer-associated cells release citrate to support tumour metastatic progressionCancer-associated stroma is recruited by cancer cells to synthesise and release citrate necessary to support metastatic progression of the disease.
The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic isletsZacarías-Fluck, et al identify and validate the Wnt receptor Fzd9 as a key effector of Myc-Wnt signaling cross-talk in a mouse model of Myc-driven pancreatic insulinomas.
Modulating HSF1 levels impacts expression of the estrogen receptor α and antiestrogen responseThis work shows that activation of the main cellular stress response pathway is responsible for antiestrogen resistance in breast cancer, a process that is reversible.