Cancer
Proteomic-based stratification of intermediate-risk prostate cancer patientsThis study demonstrates the ability of a protein-based signature to risk-stratify prostate cancer patients with Gleason grade groups 2 and 3 and predict the risk of biochemical recurrence.
Analysis of the indispensable RAD51 cofactor BRCA2 in Naganishia liquefaciens, a Basidiomycota yeastIdentification of the BRCA2 homolog in the Basidiomycota yeast Naganishia liquefaciens reveals the general attributes of fungal BRCA2 and its essential role in Rad51-mediated homologous recombination.
Intrinsic deletion at 10q23.31, including the PTEN gene locus, is aggravated upon CRISPR-Cas9–mediated genome engineering in HAP1 cells mimicking cancer profilesThe unintended 10q23.31 deletion frequency rises in HAP1 cells stressed during CRISPR-Cas9 engineering, leading to aberrant molecular and cellular changes resembling common cancer patient deletions.
Patient-specific analysis of co-expression to measure biological network rewiring in individualsCosinet has the potential to empower personalized treatment by accurately quantifying the degree of rewiring in individual samples compared with reference conditions using mechanism-related differential co-expression sub-networks.
DCAF14 regulates CDT2 to promote SET8-dependent replication fork protectionDCAF14 modulates CRL4CDT2-dependent turnover during DNA replication. Loss of DCAF14 causes nascent strand degradation due to excessive proteasomal turnover of SET8 by aberrant CDT2 activity.
Spt5 interacts genetically with Myc and is limiting for brain tumor growth in DrosophilaKnockdown of Spt5 in Drosophila affects various Myc-dependent phenotypes and delays the growth of a Myc-dependent brain tumor, thereby significantly extending the longevity of tumorous animals.
Integrins regulate hERG1 dynamics by girdin-dependent Gαi3: signaling and modeling in cancer cellsWe combine experimental data and mathematical modeling to offer a coherent explanation of the dynamics of hERG1 interaction with integrins, which governs f-actin organization and migration in cancer cells.
Exploring the basis of heterogeneity of cancer aggressiveness among the mutated POLE variantsMechanisms and consequences of POLE mutations in human cancers.
APR-246 increases tumor antigenicity independent of p53Michels, Venkatesh et al demonstrate that APR-246, a small molecule Michael acceptor, enhances tumor immunogenicity. Combination of APR-246 with immune modulation enhances antitumor responses. APR-246, initially described as a P53 stabilizer, induces immunogenicity irrespective of the tumor’s p53 status.
NRF2 connects Src tyrosine kinase to ferroptosis resistance in glioblastomaThe hyperactivation of Src tyrosine kinase in glioblastoma leads to the constitutive stabilization and activation of NRF2, thus causing resistance to ionizing radiation-induced ferroptosis.