Cancer
TRAIL-induced variation of cell signaling states provides nonheritable resistance to apoptosisThis work summarizes cellular apoptotic and signaling response to TRAIL across 10 cell lines and for the first time links signaling diversity to nongenetic resistance. This high-dimensional, single-cell approach toward TRAIL resistance sets a standard in studying nongenetic resistance.
Drug-induced chromatin accessibility changes associate with sensitivity to liver tumor promotionThis work explores quantitative chromatin accessibility, transcriptional and cis-acting gene regulatory variations underlying mouse strain–specific differences in drug-induced liver tumor promotion sensitivity.
Targeting plasma membrane phosphatidylserine content to inhibit oncogenic KRAS functionKRAS-dependent cancer cell growth is inhibited by disrupting phosphatidylserine transport to the plasma membrane by genetic knockdown of lipid exchangers ORP5 and ORP8 or by inhibition of PI4KIIIα.
A molecule inducing androgen receptor degradation and selectively targeting prostate cancer cellsA new molecule induces AR sumoylation and degradation resulting in selective growth inhibition in AR-dependent prostate cancer cells, but its activity is blunted by interference with proteasomes.
GRP78 regulates CD44v membrane homeostasis and cell spreading in tamoxifen-resistant breast cancerEndoplasmic reticulum chaperone protein GRP78 interacts with CD44v and regulates F-actin integrity, cell adhesion, and cell spreading in breast cancer cells. Targeting cell surface GRP78 by antibodies can reduce CD44v expression.
The miRNA bantam regulates growth and tumorigenesis by repressing the cell cycle regulator tribblesThis work identifies the cell cycle regulator tribbles as a target of the miRNA bantam involved in the growth regulatory and oncogenic functions of bantam in Drosophila epithelia.
Stromal fibroblasts induce metastatic tumor cell clusters via epithelial–mesenchymal plasticityThis study highlights the cellular and molecular mechanisms by which stromal fibroblasts enable human breast cancer cells to form tumor cell clusters and acquire highly invasive and metastatic traits.
De novo prediction of cell-type complexity in single-cell RNA-seq and tumor microenvironmentsThis study describes a computational method for determining statistical support to varying levels of heterogeneity provided by single-cell RNA-sequencing data with applications to tumor samples.
The cancer cell proteome and transcriptome predicts sensitivity to targeted and cytotoxic drugsThis study shows that the proteomic and transcriptomic states of cancer cells are more predictive of drug sensitivity than genomic markers for most drugs, both within and across tumor types.
Human organotypic brain slice culture: a novel framework for environmental research in neuro-oncologyTherapeutically resected, adult brain segments were maintained and characterized for an extended period to study glioblastoma progression and treatment in its almost natural environment.