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Cancer

  • MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signaling
    Open Access
    MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signaling

    Hoi-Lam Ngan, Yuchen Liu, Andrew Yuon Fong, Peony Hiu Yan Poon, Chun Kit Yeung, Sharon Suet Man Chan, Alexandria Lau, Wenying Piao, Hui Li, Jessie Sze Wing Tse, Kwok-Wai Lo, Sze Man Chan, Yu-Xiong Su, Jason Ying Kuen Chan, Chin Wang Lau, Gordon B Mills, Jennifer Rubin Grandis, Vivian Wai Yan Lui

    Hoi-Lam Ngan ... Vivian Wai Yan Lui

    Published 7 May 2020

    MAPK mutations favor HNSCC survival, revealing the broad clinical utility of MAPK pathway mutations in prognosis and potentially in precision immunotherapy.

  • Pancreatic cancer triggers diabetes through TGF-β–mediated selective depletion of islet β-cells
    Open Access
    Pancreatic cancer triggers diabetes through TGF-β–mediated selective depletion of islet β-cells

    Parash Parajuli, Thien Ly Nguyen, Céline Prunier, Mohammed S Razzaque, Keli Xu, Azeddine Atfi

    Parash Parajuli ... Azeddine Atfi

    Published 5 May 2020

    Pancreatic ductal adenocarcinoma formation culminates in hyperactivation of transforming growth factor β signaling, which in turn induces selective depletion of β-cell mass and thereby leading to new-onset diabetes.

  • Immunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytes
    Open Access
    Immunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytes

    Huda Jumaa, Marieta Caganova, Ellen J McAllister, Laura Hoenig, Xiaocui He, Deniz Saltukoglu, Kathrin Brenker, Markus Köhler, Ruth Leben, Anja E Hauser, Raluca Niesner, Klaus Rajewsky, Michael Reth, Julia Jellusova

    Huda Jumaa ... Julia Jellusova

    Published 27 April 2020

    Immunoglobulins shape mitochondrial function by driving ER expansion, this form of metabolic control is independent of the role the immunoglobulins play as part of the antigen receptor on the cell surface.

  • Oncogenic <em>ALK</em><sup><em>F1174L</em></sup> drives tumorigenesis in cutaneous squamous cell carcinoma
    Open Access
    Oncogenic ALKF1174L drives tumorigenesis in cutaneous squamous cell carcinoma

    Marco Gualandi, Maria Iorio, Olivia Engeler, André Serra-Roma, Giuseppe Gasparre, Johannes H Schulte, Daniel Hohl, Olga Shakhova

    Marco Gualandi ... Olga Shakhova

    Published 20 April 2020

    Here, we show for the first time that anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase of the insulin receptor superfamily, plays a pivotal role in the pathogenesis of cSCC.

  • Ubiquitin and SUMO conjugation as biomarkers of acute myeloid leukemias response to chemotherapies
    Open Access
    Ubiquitin and SUMO conjugation as biomarkers of acute myeloid leukemias response to chemotherapies

    Pierre Gâtel, Frédérique Brockly, Christelle Reynes, Manuela Pastore, Yosr Hicheri, Guillaume Cartron, Marc Piechaczyk, Guillaume Bossis

    Pierre Gâtel ... Guillaume Bossis

    Published 17 April 2020

    This study describes the identification of a new class of biomarkers of cancer response to therapies based on protein modification by ubiquitin and SUMO and developed tools to validate them in acute myeloid leukemia patient samples.

  • Vav1 and mutant K-Ras synergize in the early development of pancreatic ductal adenocarcinoma in mice
    Open Access
    Vav1 and mutant K-Ras synergize in the early development of pancreatic ductal adenocarcinoma in mice

    Yaser Salaymeh, Marganit Farago, Shulamit Sebban, Batel Shalom, Eli Pikarsky, Shulamit Katzav

    Yaser Salaymeh ... Shulamit Katzav

    Published 10 April 2020

    Wild-type Vav1 and mutant K-Ras synergistically accelerate pancreatic acinar-to-ductal metaplasia (ADM), thus leading to pancreatic ductal adenocarcinoma (PDAC), depending on Vav1’s activity as a GEF for Rac1.

  • CDKL3 promotes osteosarcoma progression by activating Akt/PKB
    Open Access
    CDKL3 promotes osteosarcoma progression by activating Akt/PKB

    Aina He, Lanjing Ma, Yujing Huang, Haijiao Zhang, Wei Duan, Zexu Li, Teng Fei, Junqing Yuan, Hao Wu, Liguo Liu, Yueqing Bai, Wentao Dai, Yonggang Wang, Hongtao Li, Yong Sun, Yaling Wang, Chunyan Wang, Ting Yuan, Qingcheng Yang, Songhai Tian, Min Dong, Ren Sheng, Dongxi Xiang

    Aina He ... Dongxi Xiang

    Published 31 March 2020

    This study demonstrates that CDKL3 regulates Akt activation and its downstream targets to promote OS progression, creating a therapeutically targetable vulnerability in treatment of OS.

  • BACH family members regulate angiogenesis and lymphangiogenesis by modulating VEGFC expression
    Open Access
    BACH family members regulate angiogenesis and lymphangiogenesis by modulating VEGFC expression

    Batya Cohen, Hanoch Tempelhof, Tal Raz, Roni Oren, Julian Nicenboim, Filip Bochner, Ron Even, Adam Jelinski, Raya Eilam, Shifra Ben-Dor, Yoseph Adaddi, Ofra Golani, Shlomi Lazar, Karina Yaniv, Michal Neeman

    Batya Cohen ... Michal Neeman

    Published 4 March 2020

    Our work highlights BACH family of transcription factors as a novel regulator of angiogenesis and lymphangiogenesis during zebrafish embryonic development and tumor expansion.

  • SLX4IP and telomere dynamics dictate breast cancer metastasis and therapeutic responsiveness
    Open Access
    SLX4IP and telomere dynamics dictate breast cancer metastasis and therapeutic responsiveness

    Nathaniel J Robinson, Chevaun D Morrison-Smith, Alex J Gooding, Barbara J Schiemann, Mark W Jackson, Derek J Taylor, William P Schiemann

    Nathaniel J Robinson ... William P Schiemann

    Published 18 February 2020

    An unbiased genetic screen established SLX4IP as an essential driver of telomere maintenance mechanism identity, metastatic progression, and therapeutic response of breast cancers.

  • Altering microtubule dynamics is synergistically toxic with spindle assembly checkpoint inhibition
    Open Access
    Altering microtubule dynamics is synergistically toxic with spindle assembly checkpoint inhibition

    Klaske M Schukken, Yu-Chih Lin, Petra L Bakker, Michael Schubert, Stephanie F Preuss, Judith E Simon, Hilda van den Bos, Zuzana Storchova, Maria Colomé-Tatché, Holger Bastians, Diana CJ Spierings, Floris Foijer

    Klaske M Schukken ... Floris Foijer

    Published 24 January 2020

    Chromosomal instability (CIN) is a hallmark feature of cancer cells. In this study, Schukken and colleagues screen for compounds that selectively target CIN cells and identify an inhibitor of Src kinase to be selectively toxic for CIN cells.

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  • Systems & Computational Biology (36)
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