Cancer
Identification of single-cell blasts in pediatric acute myeloid leukemia using an autoencoderThe authors present a novel automated approach for the identification of blasts and their developmental stage in a longitudinal pediatric acute myeloid leukemia (AML) cohort. KMT2A-rearranged AMLs show unstable immunophenotype, with most patients presenting a more differentiated phenotype at relapse.
Helicobacter pylori induces the expression of Lgr5 and stem cell properties in gastric target cellsHelicobacter pylori infection induces Lgr5 expression and stem cell properties in its target cells in a type IV secretion system/NF-kB-dependent manner. This effect on stemness is exacerbated by constitutive Wnt pathway activation and persists after antibiotic eradication.
Reprogramming of breast tumor–associated macrophages with modulation of arginine metabolismA shift of arginine metabolism from polyamine synthesis to nitric oxide synthesis induces reprogramming of macrophages from pro-tumor M2 to anti-tumor M1 types.
PPM1G dephosphorylates eIF4E in control of mRNA translation and cell proliferationPPM1G inhibits cell proliferation by targeting phospho-eIF4E–dependent mRNA translation.
A large-scale cancer-specific protein–DNA interaction networkThis study delineates a large-scale cancer gene TF-DNA interaction network, highlighting potential oncogene-targeted therapeutics and complex TF roles in gene regulation. This study also offers a valuable resource for future research in cancer gene regulation and for therapeutic development.
E3 ligases RNF43 and ZNRF3 display differential specificity for endocytosis of Frizzled receptorsTransmembrane E3 ligases RNF43 and ZNRF3 selectively target specific Frizzled receptors to suppress WNT signalling, offering an explanation for the cancer tissue-specific distribution of RNF43 and ZNRF3 mutations.
- Correction: A consensus molecular subtypes classification strategy for clinical colorectal cancer tissues
This work presents a novel consensus molecular subtype (CMS) classifier for colorectal cancer (CRC), optimized for RNA-sequencing data stemming from degraded RNA of clinical formalin-fixed paraffin-embedded (FFPE) tissue samples (the CMSFFPE classifier).
The type of DNA damage response after decitabine treatment depends on the level of DNMT activityChromatin-centred proteomics study in stem cells with different DNMT expression levels and activities reveals that decitabine invokes different DNA damage responses depending on the amount of the induced DNA-DNMT crosslinks.
Nono induces Gadd45b to mediate DNA repairRNA-binding proteins are often deregulated in tumours, and this study reveals that the multifunctional splicing factor Nono promotes the induction of the DNA repair factor Gadd45b to prevent genome instability in murine non–small-cell lung cancer cells.
A consensus molecular subtypes classification strategy for clinical colorectal cancer tissuesThis work presents a novel Consensus Molecular Subtypes (CMS) classifier for colorectal cancer (CRC), optimized for RNA-sequencing data stemming from degraded RNA of clinical formalin-fixed paraffin-embedded (FFPE) tissue samples (the CMSFFPE classifier).