Cancer
Identification of human gene research articles with wrongly identified nucleotide sequencesThis study describes Seek & Blastn analysis of targeted and journal corpora with manual results verification to identify human gene research articles with wrongly identified nucleotide sequence reagents.
Retinoblastoma protein regulates carcinogen susceptibility at heterochromatic cancer driver lociThe retinoblastoma protein regulates mutagenic potential via control of UV-induced DNA lesion acquisition, thus revealing novel mechanisms that contribute to its tumor suppressor capabilities.
Necrotic debris and STING exert therapeutically relevant effects on tumor cholesterol homeostasisNecrotic debris and STING affect tumor cell growth by altering cholesterol homeostasis in opposing manner, revealing that modulation of cellular cholesterol load may help control tumor growth.
Hierarchy of TGFβ/SMAD, Hippo/YAP/TAZ, and Wnt/β-catenin signaling in melanoma phenotype switchingTGFβ, YAP/TAZ, and canonical Wnt/β-catenin signaling functionally interact in a hierarchical manner to induce the switching of melanoma cells from proliferative-to-invasive cell phenotype.
TGFβ-induced expression of long noncoding lincRNA Platr18 controls breast cancer axonogenesisTumor axonogenesis is an emerging hallmark of cancer and TGF-beta is a well-known cytokine involved in the control of cancer progression. In this study we identify a novel function for the TGF-beta signaling in cancer aggressivity by promoting cancer axonogenesis.
Chromosome length and gene density contribute to micronuclear membrane stabilityChromosome identity regulates the timing of nuclear membrane rupture in micronuclei, in part through an unexpected link between high gene density and improved nuclear lamina organization.
KIF13B-mediated VEGFR2 trafficking is essential for vascular leakage and metastasis in vivoThe cancer cells secrete VEGF, which induces vascular leakage and metastasis. Inhibition of VEGFR2 trafficking to the cell surface prevents receiving VEGF, vascular leakage, and cancer metastasis.
Kinomics platform using GBM tissue identifies BTK as being associated with higher patient survivalBTK is a dominant bioactive kinase expressed within both cancer and immune cells of GBM tissue. Complex cell co-cultures might better model the impact of kinase inhibitors as therapeutics in GBM.
Suppression of isoprenylcysteine carboxylmethyltransferase compromises DNA damage repairInhibition of isoprenylcysteine carboxylmethyltransferase reduces cancer cells’ ability to repair DNA damage by suppressing the expression of critical DNA damage repair pathway genes, hence increasing their vulnerability to DNA damaging insults such as PARP inhibitors and other DNA damage agents.
Paralogous synthetic lethality underlies genetic dependencies of the cancer-mutated gene STAG2The context-dependency of genetic interactions of the cohesin gene STAG2, specifically STAG1 and the iron regulatory gene IREB2, are revealed by CRISPR-Cas9 screening in three different cellular backgrounds.