Cancer
Grp78 is required for intestinal Kras-dependent glycolysis proliferation and adenomagenesisHeterozygous deletion of Grp78 reduces Apc–Kras-driven colorectal adenomagenesis. Apc–Kras-mutated cells rely on GLUT1 transporter for glycolysis, which is inhibited by Grp78 heterozygosity.
A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistanceMechanistic characterization of a novel, lipophilic antifolate that suppresses growth of FPGS-deficient cells that are linked to methotrexate resistance and relapse in cancer patients.
SF3B1 mutation–mediated sensitization to H3B-8800 splicing inhibitor in chronic lymphocytic leukemiaUnderstanding the pathogenic mechanisms of SF3B1 mutation can help unravel their contribution in patients’ worse prognosis. The cytotoxic effects and delayed leukemic infiltration induced by H3B-8800 support the potential use of SF3B1 inhibitors as a novel therapy in CLL.
HGF/c-Met/β1-integrin signalling axis induces tunneling nanotubes in A549 lung adenocarcinoma cellsInteractions between hepatocyte growth factor (HGF), the c-Met receptor, and β1-integrin induce tunneling nanotubes in A549 cells; paxillin and the downstream MAPK and PI3K pathways and the Arp2/3 complex drive HGF-induced TNT formation.
Refining the genetic risk of breast cancer with rare haplotypes and pattern miningA closed-pattern mining algorithm helps identify rare, noncontiguous haplotypes underlying breast cancer risk in British women in the UK Biobank.
Basonuclin-2 regulates extracellular matrix production and degradationBasonuclin-2 (BNC2) is identified as a novel regulator of genes associated with the extracellular matrix and cytokines in fibroblasts. BNC2 is thereby identified as a novel regulator of the tumour microenvironment where its high expression correlates with poor prognosis.
Exploring the impact of dexamethasone on gene regulation in myeloma cellsThe study uncovers epigenomic changes associated with dexamethasone response heterogeneity in myeloma cells, revealing rewired promoter–enhancer interactions and DNA loop stabilization.
Regulation of hPCL3 isoforms’ ubiquitination by TRIM21 in non-small cell lung cancer progressionhPCL3 isoforms, hPCL3S and hPCL3L, are studied in NSCLC. Elevated expression of both isoforms correlates with poor survival. Inhibiting hPCL3S reduces cell growth, invasion, and migration, suggesting it as a potential therapeutic target.
PASCAR: a multiscale framework to explore the design space of constitutive and inducible CAR T cellsAn experimentally validated protein abundance structured population dynamic model for CAR T cells (PASCAR) that integrates processes from molecules to single cells to cell populations and systematically explores the design space of constitutive and tunable CAR T cells.
Full-length transcript alterations in human bronchial epithelial cells with U2AF1 S34F mutationsUsing long-read Nanopore cDNA sequencing, this study identifies full-length transcripts associated with U2AF1 S34F mutations revealing effects on translation regulation of specific genes.