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Cancer

  • Paneth cell–derived growth factors support tumorigenesis in the small intestine
    Open Access
    Paneth cell–derived growth factors support tumorigenesis in the small intestine

    Qing Chen, Kohei Suzuki, Luis Sifuentes-Dominguez, Naoteru Miyata, Jie Song, Adam Lopez, Petro Starokadomskyy, Purva Gopal, Igor Dozmorov, Shuai Tan, Bujun Ge, Ezra Burstein

    Qing Chen ... Ezra Burstein

    Published 28 December 2020

    Paneth cells, known for their production of antimicrobial peptides and growth factors in the gut epithelium, are found to play a key role in intestinal tumor formation through secretion of Wnt3.

  • FAM83F regulates canonical Wnt signalling through an interaction with CK1α
    Open Access
    FAM83F regulates canonical Wnt signalling through an interaction with CK1α

    Karen Dunbar, Rebecca A Jones, Kevin Dingwell, Thomas J Macartney, James C Smith, Gopal P Sapkota

    Karen Dunbar ... Gopal P Sapkota

    Published 24 December 2020

    FAM83F directs CK1α to the plasma membrane, and through its association with CK1α, FAM83F mediates canonical Wnt signalling.

  • The chromatin landscape of primary synovial sarcoma organoids is linked to specific epigenetic mechanisms and dependencies
    Open Access
    The chromatin landscape of primary synovial sarcoma organoids is linked to specific epigenetic mechanisms and dependencies

    Gaylor Boulay, Luisa Cironi, Sara P Garcia, Shruthi Rengarajan, Yu-Hang Xing, Lukuo Lee, Mary E Awad, Beverly Naigles, Sowmya Iyer, Liliane C Broye, Tugba Keskin, Alexandra Cauderay, Carlo Fusco, Igor Letovanec, Ivan Chebib, Petur Gunnalugur Nielsen, Stéphane Tercier, Stéphane Cherix, Tu Nguyen-Ngoc, Gregory Cote, Edwin Choy, Paolo Provero, Mario L Suvà, Miguel N Rivera, Ivan Stamenkovic, Nicolò Riggi

    Gaylor Boulay ... Nicolò Riggi

    Published 23 December 2020

    We have addressed the mechanisms by which the fusion protein SS18-SSX modifies the epigenome toward the development of synovial sarcoma and the establishment of its potentially targetable vulnerabilities.

  • Requirement of DNMT1 to orchestrate epigenomic reprogramming for NPM-ALK–driven lymphomagenesis
    Open Access
    Requirement of DNMT1 to orchestrate epigenomic reprogramming for NPM-ALK–driven lymphomagenesis

    Elisa Redl, Raheleh Sheibani-Tezerji, Crhistian de Jesus Cardona, Patricia Hamminger, Gerald Timelthaler, Melanie Rosalia Hassler, Maša Zrimšek, Sabine Lagger, Thomas Dillinger, Lorena Hofbauer, Kristina Draganić, Andreas Tiefenbacher, Michael Kothmayer, Charles H Dietz, Bernard H Ramsahoye, Lukas Kenner, Christoph Bock, Christian Seiser, Wilfried Ellmeier, Gabriele Schweikert, Gerda Egger

    Elisa Redl ... Gerda Egger

    Published 11 December 2020

    NPM-ALK–driven lymphoma in mice is dependent on MYC signaling and epigenomic reprogramming via DNA methyltransferases, resulting in heterogenous DNA methylation signatures reminiscent of human lymphoma.

  • Sustained <em>Helicobacter pylori</em> infection accelerates gastric dysplasia in a mouse model
    Open Access
    Sustained Helicobacter pylori infection accelerates gastric dysplasia in a mouse model

    Valerie P O’Brien, Amanda L Koehne, Julien Dubrulle, Armando E Rodriguez, Christina K Leverich, V Paul Kong, Jean S Campbell, Robert H Pierce, James R Goldenring, Eunyoung Choi, Nina R Salama

    Valerie P O’Brien ... Nina R Salama

    Published 11 December 2020

    Hp infection was found to alter metaplasia and accelerate dysplasia in mice. Thus, Hp can promote gastric preneoplastic progression, in addition to its known role in initiating chronic inflammation.

  • Loss of <em>Jag1</em> cooperates with oncogenic <em>Kras</em> to induce pancreatic cystic neoplasms
    Open Access
    Loss of Jag1 cooperates with oncogenic Kras to induce pancreatic cystic neoplasms

    Wen-Cheng Chung, Lavanya Challagundla, Yunyun Zhou, Min Li, Azeddine Atfi, Keli Xu

    Wen-Cheng Chung ... Keli Xu

    Published 2 December 2020

    Jag1 functions as a tumor suppressor in delaying pancreatic cancer precursor, while at the same time, promotes a phenotypic switch from benign cystic lesions to invasive carcinoma of the pancreas.

  • Single-cell RNA sequencing of human breast tumour-infiltrating immune cells reveals a γδ T-cell subtype associated with good clinical outcome
    Open Access
    Single-cell RNA sequencing of human breast tumour-infiltrating immune cells reveals a γδ T-cell subtype associated with good clinical outcome

    Katerina Boufea, Víctor González-Huici, Marcus Lindberg, Stefan Symeonides, Olga Oikonomidou, Nizar N Batada

    Katerina Boufea ... Nizar N Batada

    Published 2 December 2020

    Single-cell sequencing of γδ-T cells from human blood and tumours revealed novel markers of subtypes with distinct effector functions and a subtype that is associated with favourable clinical outcome.

  • Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers
    Open Access
    Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers

    Joseph A Newman, Angeline E Gavard, Simone Lieb, Madhwesh C Ravichandran, Katja Hauer, Patrick Werni, Leonhard Geist, Jark Böttcher, John R Engen, Klaus Rumpel, Matthias Samwer, Mark Petronczki, Opher Gileadi

    Joseph A Newman ... Opher Gileadi

    Published 16 November 2020

    WRN is a key drug target for cancers with microsatellite instability. A crystal structure of the helicase domain of WRN identifies its unique features and provides a basis for structure-guided design of inhibitors.

  • Myeloid transformation by <em>MLL</em>-<em>ENL</em> depends strictly on C/EBP
    Open Access
    Myeloid transformation by MLL-ENL depends strictly on C/EBP

    Radoslaw Wesolowski, Elisabeth Kowenz-Leutz, Karin Zimmermann, Dorothea Dörr, Maria Hofstätter, Robert K Slany, Alexander Mildner, Achim Leutz

    Radoslaw Wesolowski ... Achim Leutz

    Published 3 November 2020

    This publication shows that C/EBP (CCAAT enhancer–binding protein) transcription factors are mandatory for maintaining the myeloid leukemic phenotype, suggesting a therapeutic option by interfering with the non-oncogenic C/EBP dependence.

  • In vivo CRISPR/Cas9 knockout screen: TCEAL1 silencing enhances docetaxel efficacy in prostate cancer
    Open Access
    In vivo CRISPR/Cas9 knockout screen: TCEAL1 silencing enhances docetaxel efficacy in prostate cancer

    Linda K Rushworth, Victoria Harle, Peter Repiscak, William Clark, Robin Shaw, Holly Hall, Martin Bushell, Hing Y Leung, Rachana Patel

    Linda K Rushworth ... Rachana Patel

    Published 8 October 2020

    A whole genome in vivo CRISPR/Cas9 screen identifies TCEAL1 as a potential target to sensitise prostate cancer cells to docetaxel to improve the efficacy of chemotherapy.

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