Cancer
Functional annotation of noncoding mutations in cancerRecurrent regulatory mutations affecting transcription factor binding sites in 2,500 cancer samples.
Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancerThis work identifies the use of exosomes to specifically deliver CRISPR/Cas9 to target oncogenic KrasG12D mutation in pancreatic cancer as a nonviral therapeutic strategy.
The stabilized Pol31–Pol3 interface counteracts Pol32 ablation with differential effects on repairDNA pol δ is needed for lagging strand replication and DNA repair. We shed light on both distinct and common roles of the second and third subunits, Pol31 and Pol32, in S-phase linked repair pathways.
UVB mutagenesis differs in Nras- and Braf-mutant mouse models of melanomaA single, neonatal UVB exposure drives greater UV-signature production in Braf- than Nras-mutant murine melanomas.
Negative correlation of single-cell PAX3:FOXO1 expression with tumorigenicity in rhabdomyosarcomaSingle-cell PAX3:FOXO1 expression in rhabdomyosarcoma is variable. PAX3:FOXO1 low cell states are characterized by more efficient adhesion, migration and tumor-propagating capacity.
Deletion of a pseudogene within a fragile site triggers the oncogenic expression of the mitotic CCSER1 geneFrequent deletions impacting the FRA4F fragile site leads to the oncogenic overexpression of the corresponding CCSER1 gene, through the deletion of the TMSB4XP8 pseudogene. The ensuing CCSER1 overexpression elicits mitotic instability, targetable with aurora kinase inhibitors.
Macrophages-induced IL-18–mediated eosinophilia promotes characteristics of pancreatic malignancyThe current study presents first CP murine model that show IL-18–induced eosinophil inflammation-mediated induction of oncogenic proteins and several pathological malignant characteristics.
WBP2 inhibits microRNA biogenesis via interaction with the microprocessor complexWBP2 protein blocks the microRNA biogenesis via physical interactions with the microprocessor complex, and reverts the tumor-suppressive role of DGCR8.
Multifaceted regulation of hepatic lipid metabolism by YY1This study shows that YY1 regulates hepatic lipid metabolism by directly or indirectly regulating the expression of several key upstream transcription factors and their coactivators.
Specific N-cadherin–dependent pathways drive human breast cancer dormancy in bone marrowCDH2 is required for connexin 43 (Cx43)–mediated gap junction intercellular communication between breast cancer cells and bone marrow niche cells to achieve dormancy and chemoresistance.