Cancer
Polycomb group ring finger protein 6 suppresses Myc-induced lymphomagenesisMax dimerizes with Mga to form the repressive complex PRC1.6; another PRC1.6 subunit, Pcgf6, suppresses Myc-induced lymphomagenesis but, unexpectedly, does so in a Mga- and PRC1.6-independent manner.
The hexosamine pathway and coat complex II promote malignant adaptation to nutrient scarcityWe present adaptive mechanisms of resistance of lung adenocarcinoma to their harsh microenvironment, which typically contains a lower glucose concentration compared with normal tissue.
ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathwayESCRT-I deficiency impairs lysosome membrane turnover and induces homeostatic responses to lysosomal nutrient starvation including activation of MiT-TFE signaling caused by inhibition of the substrate-specific mTORC1 pathway.
TET2-mediated epigenetic reprogramming of breast cancer cells impairs lysosome biogenesisTET2-mediated oxidation of 5-methylcytosine establishes an antiviral state and contributes to MYC-dependent down-regulation of genes involved in lysosome biogenesis and function in breast cancer cells.
Rab11 endosomes and Pericentrin coordinate centrosome movement during pre-abscission in vivoCell division completes when the two daughter cells move their oldest centrosome towards the cytokinetic bridge, which is then cleaved during abscission. The GTPase, Rab11, and the centrosome protein, Pericentrin, work together to coordinate this movement.
Spatial proteomics finds CD155 and Endophilin-A1 as mediators of growth and invasion in medulloblastomaSpatial proteomics identifies MAP4K4 as a regulator of the plasma membrane-associated proteome and reveals CD155 and EndoA1 as mediators of proliferation and invasiveness in medulloblastoma cells.
Meflin-positive cancer-associated fibroblasts enhance tumor response to immune checkpoint blockadeMeflin/ISLR is the marker of a cancer-associated fibroblast subset that enhances tumor response to immune checkpoint blockade therapy.
Quantitative profiling of adaptation to cyclin E overproductionDetailed analysis of individual human cells responding then adapting to the stress of chronic cyclin E overproduction, which inhibits DNA replication origin licensing by inducing premature S phase.
Human BRCA pathogenic variants were originated during recent human historyEvolutionary origin of pathogenic variants in human BRCA1 and BRCA2.
Nucleotide biosynthesis links glutathione metabolism to ferroptosis sensitivityThe tumor suppressor protein p53 inhibits ferroptosis by reducing the consumption of glutathione in nucleotide biosynthesis.