Cancer
Direct visualization of emergent metastatic features within an ex vivo model of the tumor microenvironmentObserving early metastases in vivo is virtually impossible, and most culture systems lack the conditions that tumor cells encounter early in the metastatic process. We thus developed the 3MIC—an ex vivo cell culture system—allowing the direct observation of nascent metastases.
PPP3CB overexpression mediates EGFR TKI resistance in lung tumors via calcineurin/MEK/ERK signalingA triple osimertinib/calcineurin A/trametinib combination of treatment overcomes acquired resistance to EGFR TKI in EGFR-mutant lung adenocarcinoma cells that overexpress PPP3CB.
Crosstalk between bone metastatic cancer cells and sensory nerves in bone metastatic progressionCrosstalk between bone metastatic cancer cells and sensory nerves has not yet been fully elucidated. We demonstrate the involvement of CGRP-expressing sensory nerves in bone metastatic progression and identify the CGRP/CRLR axis as a potential therapeutic target for bone metastasis.
Mitochondrial double-stranded RNA homeostasis depends on cell-cycle progressionThe accumulation of mitochondrial double-stranded RNA (mt-dsRNA) in cancer cells depends on cell proliferation status. Mt-dsRNA is more abundant in patient lung adenocarcinoma compared with healthy tissue.
Helicobacter pylori induces the expression of Lgr5 and stem cell properties in gastric target cellsHelicobacter pylori infection induces Lgr5 expression and stem cell properties in its target cells in a type IV secretion system/NF-kB-dependent manner. This effect on stemness is exacerbated by constitutive Wnt pathway activation and persists after antibiotic eradication.
Reprogramming of breast tumor–associated macrophages with modulation of arginine metabolismA shift of arginine metabolism from polyamine synthesis to nitric oxide synthesis induces reprogramming of macrophages from pro-tumor M2 to anti-tumor M1 types.
Identification of single-cell blasts in pediatric acute myeloid leukemia using an autoencoderThe authors present a novel automated approach for the identification of blasts and their developmental stage in a longitudinal pediatric acute myeloid leukemia (AML) cohort. KMT2A-rearranged AMLs show unstable immunophenotype, with most patients presenting a more differentiated phenotype at relapse.
PPM1G dephosphorylates eIF4E in control of mRNA translation and cell proliferationPPM1G inhibits cell proliferation by targeting phospho-eIF4E–dependent mRNA translation.
A large-scale cancer-specific protein–DNA interaction networkThis study delineates a large-scale cancer gene TF-DNA interaction network, highlighting potential oncogene-targeted therapeutics and complex TF roles in gene regulation. This study also offers a valuable resource for future research in cancer gene regulation and for therapeutic development.
E3 ligases RNF43 and ZNRF3 display differential specificity for endocytosis of Frizzled receptorsTransmembrane E3 ligases RNF43 and ZNRF3 selectively target specific Frizzled receptors to suppress WNT signalling, offering an explanation for the cancer tissue-specific distribution of RNF43 and ZNRF3 mutations.