Cancer
CNN2 silencing inhibits colorectal cancer development through promoting ubiquitination of EGR1In colorectal cancer (CRC), CNN2 was found to form a complex with YAP1 and EGR1, thus regulating EGR1 expression and promoting CRC, which could be considered as a potential therapeutic target for CRC.
Antibody reliability influences observed mRNA–protein correlations in tumour samplesUpadhya and Ryan show that the reliability of antibodies used for RPPA profiling influences the mRNA-protein correlations observed in tumour cohorts.
The C-type lectin domain of CD62P (P-selectin) functions as an integrin ligandThe lectin domain of CD62P specifically binds to and activates integrins. CD62P-integrin interactions may function in a diverse set of cell–cell adhesions given that integrins are widely expressed.
MiR-532-3p inhibited the methylation of SOCS2 to suppress the progression of PC by targeting DNMT3AMiR-532-3p has a low expression in pancreatic cancer, but its overexpression can inhibit the tumor progression via DNMT3A-dependent inhibition of SOCS2 methylation.
Proteomic analysis reveals microvesicles containing NAMPT as mediators of radioresistance in gliomaGlioma patients often relapse because of resistance to radiation therapy. The transfer of the metabolic enzyme NAMPT via microvesicles and the accompanying elevated levels of NAD are found to be a mechanism by which glioma cells become resistant to radiation.
An OMA1 redox site controls mitochondrial homeostasis, sarcoma growth, and immunogenicityThis work describes how a mutation affecting mitochondrial metabolism in a sarcoma model induces protective immunity against the tumor and how this result might be relevant for sarcoma patients.
Endemic Burkitt lymphoma avatar mouse models for exploring inter-patient tumor variation and testing targeted therapiesPatient-derived tumor models show promise for evaluating novel cancer treatments that could improve outcomes for African children diagnosed with EBV-associated endemic Burkitt lymphoma.
RAS and PP2A activities converge on epigenetic gene regulationThis study reveals a hidden regulatory layer in epigenetic gene expression in cancer by co-operative phosphoregulation by RAS and tumor suppressor phosphatase PP2A.
Three-dimensional growth reveals fine-tuning of 5-lipoxygenase by proliferative pathways in cancerThe expression of 5-lipoxygenase, the key enzyme in leukotriene biosynthesis, is suppressed in proliferating cancer cells by a PI3K/mTORC-2– and MEK-1/ERK-dependent axis involving E2F1 and b-Myb.
AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradationThis study shows that TPX2 co-overexpression in non-transformed human cells induces AurkA nuclear accumulation and promotes its non-mitotic oncogenic functions.