Cancer
Lipid-driven Src self-association modulates its transformation capacityLipid-mediated condensates formed by Src on supported lipid membranes are dependent of a conserved lysine cluster in its SH4 domain and modulate its transforming capacity.
An ISR-independent role of GCN2 prevents excessive ribosome biogenesis and mRNA translationGCN2 restrains ribosome biogenesis at mRNA and translational levels, keeps protein synthesis in check, and maintains metabolic homeostasis independently of the ISR in a subset of cancers.
Screening of homing and tissue-penetrating peptides by microdialysis and in vivo phage displayIn vivo phage display combined with microdialysis can be used for the discovery of vascular homing peptides capable of extravasation and tissue penetration in the target organ.
Unconventional receptor functions and location-biased signaling of the lactate GPCR in the nucleusHCAR1 as GPCR for Lactate is highly expressed in many cancers due to the Warburg effect. We show HCAR1 has a nuclear localization where it promotes cancer malignancy through chromatin regulation, DNA damage repair, translational regulation, and intranuclear signaling.
UNC119 regulates T-cell receptor signalling in primary T cells and T acute lymphocytic leukaemiaInhibiting the ciliary protein UNC119 in primary T cells alters LCK localisation and function independently of the phosphorylation state. UNC119 also may represent a therapeutic target in T acute lymphocytic leukaemia as UNC119 inhibition reduced cancer cell growth.
Mechanical compressive forces increase PI3K output signaling in breast and pancreatic cancer cellsThis article provides a proof-of-concept showing that the therapeutic impact of targeted therapies on solid cancer cells is dependent on compressive mechanical context.
DICE: fast and accurate distance-based reconstruction of single-cell copy number phylogeniesThis work presents two new computational methods for reconstructing tumor cell lineage trees from single-cell copy number data.
Mitochondrial signatures shape phenotype switching and apoptosis in response to PLK1 inhibitorsSpecific mitochondrial proteins are associated with resistance to treatments targeting polo-like kinase 1 activity or expression in melanoma. Resistant cells are less apoptotic and trigger a transcriptional program of dedifferentiation and a pro-inflammatory phenotype.
Depleting chemoresponsive mitochondrial fission mediator DRP1 does not mitigate sarcoma resistanceThe mitochondrial fission mediator DRP1 levels and activation are modulated upon chemotherapy exposure, yet depleting DRP1 does not restore chemosensitivity in the most common pediatric sarcomas.
Hypoxia favors tumor growth in colorectal cancer in an integrin αDβ1/hemoglobin δ-dependent mannerColorectal cancers co-express the αDβ1 integrin and hemoglobin δ, and down-regulation of either protein in hypoxia inhibited oxygen uptake and cell proliferation.