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Cancer

  • DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF
    Open Access
    DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF

    Nuria Gutierrez-Prat, Hedwig L Zuberer, Luca Mangano, Zahra Karimaddini, Luise Wolf, Stefka Tyanova, Lisa C Wellinger, Daniel Marbach, Vera Griesser, Piergiorgio Pettazzoni, James R Bischoff, Daniel Rohle, Chiara Palladino, Igor Vivanco

    Nuria Gutierrez-Prat ... Igor Vivanco

    Published 17 May 2022

    Our study demonstrates that in BRAF- and NRAS-mutant MITF-proficient melanoma, the DUSP4 MAPK phosphatase restricts MAPK activation and prevents oncogenic overdose through modulation of MITF function.

  • The HDL particle composition determines its antitumor activity in pancreatic cancer
    Open Access
    The HDL particle composition determines its antitumor activity in pancreatic cancer

    Raimund Oberle, Kristina Kührer, Tamina Österreicher, Florian Weber, Stefanie Steinbauer, Florian Udonta, Mark Wroblewski, Isabel Ben-Batalla, Ingrid Hassl, Jakob Körbelin, Matthias Unseld, Matti Jauhiainen, Birgit Plochberger, Clemens Röhrl, Markus Hengstschläger, Sonja Loges, Herbert Stangl

    Raimund Oberle ... Herbert Stangl

    Published 16 May 2022

    The authors show that particle composition–dependent, efficient HDL-mediated cholesterol depletion induces apoptosis and interferes with the aggressive growth characteristics of pancreatic cancer cells.

  • Genetic and compound screens uncover factors modulating cancer cell response to indisulam
    Open Access
    Genetic and compound screens uncover factors modulating cancer cell response to indisulam

    Ziva Pogacar, Kelvin Groot, Fleur Jochems, Matheus Dos Santos Dias, Antonio Mulero-Sánchez, Ben Morris, Mieke Roosen, Leyma Wardak, Giulia De Conti, Arno Velds, Cor Lieftink, Bram Thijssen, Roderick L Beijersbergen, René Bernards, Rodrigo Leite de Oliveira

    Ziva Pogacar ... Rodrigo Leite de Oliveira

    Published 9 May 2022

    The authors identify that loss of SRPK1 sensitises cancer cells to indisulam treatment and loss of CAND1 confers resistance. Resistance is mediated through RBM39. Furthermore, pharmacological Bcl-xL inhibition prevents acquired resistance to indisulam.

  • Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28 ubiquitylation
    Open Access
    Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28 ubiquitylation

    Ke-Jun Han, Valeryia Mikalayeva, Scott A Gerber, Arminja N Kettenbach, Vytenis A Skeberdis, Rytis Prekeris

    Ke-Jun Han ... Rytis Prekeris

    Published 5 May 2022

    The role of novel Rab40c/CRL5 ubiquitylation complex in regulating PP6 activity and cell migration.

  • Systematic identification of ALK substrates by integrated phosphoproteome and interactome analysis
    Open Access
    Systematic identification of ALK substrates by integrated phosphoproteome and interactome analysis

    Jun Adachi, Akemi Kakudo, Yoko Takada, Junko Isoyama, Narumi Ikemoto, Yuichi Abe, Ryohei Narumi, Satoshi Muraoka, Daigo Gunji, Yasuhiro Hara, Ryohei Katayama, Takeshi Tomonaga

    Jun Adachi ... Takeshi Tomonaga

    Published 4 May 2022

    Integrated analysis of the phosphoproteome and interactome of anaplastic lymphoma kinase (ALK)-overexpressing HEK 293 cells revealed 37 ALK substrate candidates, contributing to the improvement of kinase activity prediction.

  • Exploring YAP1-centered networks linking dysfunctional CFTR to epithelial–mesenchymal transition
    Open Access
    Exploring YAP1-centered networks linking dysfunctional CFTR to epithelial–mesenchymal transition

    Margarida C Quaresma, Hugo M Botelho, Ines Pankonien, Cláudia S Rodrigues, Madalena C Pinto, Pau R Costa, Aires Duarte, Margarida D Amaral

    Margarida C Quaresma ... Margarida D Amaral

    Published 2 May 2022

    In this work, a systems biology approach identifies potentially dysregulated EMT signaling in CF (including the Hippo, Wnt, TGF-β, p53, and MYC pathways), integrated by YAP1 and TEAD4.

  • Fluorescent tracking identifies key migratory dendritic cells in the lymph node after radiotherapy
    Open Access
    Fluorescent tracking identifies key migratory dendritic cells in the lymph node after radiotherapy

    Tiffany C Blair, Shelly Bambina, Gwen F Kramer, Alexa K Dowdell, Alejandro F Alice, Jason R Baird, Amanda W Lund, Brian D Piening, Marka R Crittenden, Michael J Gough

    Tiffany C Blair ... Michael J Gough

    Published 29 April 2022

    Radiation therapy impacts all cells within the treatment field. Using novel technology, we track dendritic cells from the tumor to lymph nodes and demonstrate their importance in immune control of tumors.

  • The miR-26 family regulates early B cell development and transformation
    Open Access
    The miR-26 family regulates early B cell development and transformation

    Katharina Hutter, Silke E Lindner, Constanze Kurschat, Thomas Rülicke, Andreas Villunger, Sebastian Herzog

    Katharina Hutter ... Sebastian Herzog

    Published 22 April 2022

    We show that the activity of the miR-26 family determines early B cell behavior: high miR-26 levels promote cell expansion and block the pre-B to immature B cell transition, whereas a miR-26 reduction limits expansion and enhances pre-B cell differentiation.

  • Polycomb group ring finger protein 6 suppresses Myc-induced lymphomagenesis
    Open Access
    Polycomb group ring finger protein 6 suppresses Myc-induced lymphomagenesis

    Nina Tanaskovic, Mattia Dalsass, Marco Filipuzzi, Giorgia Ceccotti, Alessandro Verrecchia, Paola Nicoli, Mirko Doni, Daniela Olivero, Diego Pasini, Haruhiko Koseki, Arianna Sabò, Andrea Bisso, Bruno Amati

    Nina Tanaskovic ... Bruno Amati

    Published 14 April 2022

    Max dimerizes with Mga to form the repressive complex PRC1.6; another PRC1.6 subunit, Pcgf6, suppresses Myc-induced lymphomagenesis but, unexpectedly, does so in a Mga- and PRC1.6-independent manner.

  • The hexosamine pathway and coat complex II promote malignant adaptation to nutrient scarcity
    Open Access
    The hexosamine pathway and coat complex II promote malignant adaptation to nutrient scarcity

    Helena Dragic, Audrey Barthelaix, Cédric Duret, Simon Le Goupil, Hadrien Laprade, Sophie Martin, Sabine Brugière, Yohann Couté, Christelle Machon, Jerome Guitton, Justine Rudewicz, Paul Hofman, Serge Lebecque, Cedric Chaveroux, Carole Ferraro-Peyret, Toufic Renno, Serge N Manié

    Helena Dragic ... Serge N Manié

    Published 8 April 2022

    We present adaptive mechanisms of resistance of lung adenocarcinoma to their harsh microenvironment, which typically contains a lower glucose concentration compared with normal tissue.

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