Cancer
DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITFOur study demonstrates that in BRAF- and NRAS-mutant MITF-proficient melanoma, the DUSP4 MAPK phosphatase restricts MAPK activation and prevents oncogenic overdose through modulation of MITF function.
The HDL particle composition determines its antitumor activity in pancreatic cancerThe authors show that particle composition–dependent, efficient HDL-mediated cholesterol depletion induces apoptosis and interferes with the aggressive growth characteristics of pancreatic cancer cells.
Genetic and compound screens uncover factors modulating cancer cell response to indisulamThe authors identify that loss of SRPK1 sensitises cancer cells to indisulam treatment and loss of CAND1 confers resistance. Resistance is mediated through RBM39. Furthermore, pharmacological Bcl-xL inhibition prevents acquired resistance to indisulam.
Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28 ubiquitylationThe role of novel Rab40c/CRL5 ubiquitylation complex in regulating PP6 activity and cell migration.
Systematic identification of ALK substrates by integrated phosphoproteome and interactome analysisIntegrated analysis of the phosphoproteome and interactome of anaplastic lymphoma kinase (ALK)-overexpressing HEK 293 cells revealed 37 ALK substrate candidates, contributing to the improvement of kinase activity prediction.
Exploring YAP1-centered networks linking dysfunctional CFTR to epithelial–mesenchymal transitionIn this work, a systems biology approach identifies potentially dysregulated EMT signaling in CF (including the Hippo, Wnt, TGF-β, p53, and MYC pathways), integrated by YAP1 and TEAD4.
Fluorescent tracking identifies key migratory dendritic cells in the lymph node after radiotherapyRadiation therapy impacts all cells within the treatment field. Using novel technology, we track dendritic cells from the tumor to lymph nodes and demonstrate their importance in immune control of tumors.
The miR-26 family regulates early B cell development and transformationWe show that the activity of the miR-26 family determines early B cell behavior: high miR-26 levels promote cell expansion and block the pre-B to immature B cell transition, whereas a miR-26 reduction limits expansion and enhances pre-B cell differentiation.
Polycomb group ring finger protein 6 suppresses Myc-induced lymphomagenesisMax dimerizes with Mga to form the repressive complex PRC1.6; another PRC1.6 subunit, Pcgf6, suppresses Myc-induced lymphomagenesis but, unexpectedly, does so in a Mga- and PRC1.6-independent manner.
The hexosamine pathway and coat complex II promote malignant adaptation to nutrient scarcityWe present adaptive mechanisms of resistance of lung adenocarcinoma to their harsh microenvironment, which typically contains a lower glucose concentration compared with normal tissue.