Cancer
Small molecule inhibitors and a kinase-dead expressing mouse model demonstrate that the kinase activity of Chk1 is essential for mouse embryos and cancer cellsThe study use small molecule inhibitors and a kinase-dead expressing mouse model to demonstrate that the kinase activity of Chk1 is essential for mouse embryos and cancer cells.
STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancersThis work highlights the degradation of STAG1 and inhibition of its interaction with cohesin as promising therapeutic strategies for exploiting synthetic lethality to treat STAG2-mutated tumors and lays the groundwork for the discovery of STAG1-directed small molecules.
Tradeoff between metabolic i-proteasome addiction and immune evasion in triple-negative breast cancerEngaging the immunoproteasome helps maintain proteostasis during TNBC development, but ultimately leads to increased immune visibility and favorable prognosis. Assessing i-proteasome expression could augment the prognostic and/or predictive value of TILs assessment in diagnostic practice.
Integrin α3β1 in hair bulge stem cells modulates CCN2 expression and promotes skin tumorigenesisAlthough hair bulge stem cells are not the cancer cells-of-origin, they contribute to two-stage DMBA/TPA skin carcinogenesis in an α3β1-dependent manner.
MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signalingMAPK mutations favor HNSCC survival, revealing the broad clinical utility of MAPK pathway mutations in prognosis and potentially in precision immunotherapy.
Pancreatic cancer triggers diabetes through TGF-β–mediated selective depletion of islet β-cellsPancreatic ductal adenocarcinoma formation culminates in hyperactivation of transforming growth factor β signaling, which in turn induces selective depletion of β-cell mass and thereby leading to new-onset diabetes.
Immunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytesImmunoglobulins shape mitochondrial function by driving ER expansion, this form of metabolic control is independent of the role the immunoglobulins play as part of the antigen receptor on the cell surface.
Oncogenic ALKF1174L drives tumorigenesis in cutaneous squamous cell carcinomaHere, we show for the first time that anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase of the insulin receptor superfamily, plays a pivotal role in the pathogenesis of cSCC.
Ubiquitin and SUMO conjugation as biomarkers of acute myeloid leukemias response to chemotherapiesThis study describes the identification of a new class of biomarkers of cancer response to therapies based on protein modification by ubiquitin and SUMO and developed tools to validate them in acute myeloid leukemia patient samples.
Vav1 and mutant K-Ras synergize in the early development of pancreatic ductal adenocarcinoma in miceWild-type Vav1 and mutant K-Ras synergistically accelerate pancreatic acinar-to-ductal metaplasia (ADM), thus leading to pancreatic ductal adenocarcinoma (PDAC), depending on Vav1’s activity as a GEF for Rac1.