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Cancer

  • CNN2 silencing inhibits colorectal cancer development through promoting ubiquitination of EGR1
    Open Access
    CNN2 silencing inhibits colorectal cancer development through promoting ubiquitination of EGR1

    Jinghu He, Xiaohong Yang, Chuansen Zhang, Ang Li, Wei Wang, Junjie Xing, Jifu E, Xiaodong Xu, Hao Wang, Enda Yu, Debing Shi, Hantao Wang

    Jinghu He ... Hantao Wang

    Published 15 May 2023

    In colorectal cancer (CRC), CNN2 was found to form a complex with YAP1 and EGR1, thus regulating EGR1 expression and promoting CRC, which could be considered as a potential therapeutic target for CRC.

  • Antibody reliability influences observed mRNA–protein correlations in tumour samples
    Open Access
    Antibody reliability influences observed mRNA–protein correlations in tumour samples

    Swathi Ramachandra Upadhya, Colm J Ryan

    Swathi Ramachandra Upadhya ... Colm J Ryan

    Published 11 May 2023

    Upadhya and Ryan show that the reliability of antibodies used for RPPA profiling influences the mRNA-protein correlations observed in tumour cohorts.

  • The C-type lectin domain of CD62P (P-selectin) functions as an integrin ligand
    Open Access
    The C-type lectin domain of CD62P (P-selectin) functions as an integrin ligand

    Yoko K Takada, Scott I Simon, Yoshikazu Takada

    Yoko K Takada ... Yoshikazu Takada

    Published 25 April 2023

    The lectin domain of CD62P specifically binds to and activates integrins. CD62P-integrin interactions may function in a diverse set of cell–cell adhesions given that integrins are widely expressed.

  • <em>MiR-532-3p</em> inhibited the methylation of <em>SOCS2</em> to suppress the progression of PC by targeting <em>DNMT3A</em>
    Open Access
    MiR-532-3p inhibited the methylation of SOCS2 to suppress the progression of PC by targeting DNMT3A

    Kaiqiong Wang, Dongwei Gong, Xin Qiao, Jinfang Zheng

    Kaiqiong Wang ... Jinfang Zheng

    Published 21 April 2023

    MiR-532-3p has a low expression in pancreatic cancer, but its overexpression can inhibit the tumor progression via DNMT3A-dependent inhibition of SOCS2 methylation.

  • Proteomic analysis reveals microvesicles containing NAMPT as mediators of radioresistance in glioma
    Open Access
    Proteomic analysis reveals microvesicles containing NAMPT as mediators of radioresistance in glioma

    Elena Panizza, Brandon D Regalado, Fangyu Wang, Ichiro Nakano, Nathaniel M Vacanti, Richard A Cerione, Marc A Antonyak

    Elena Panizza ... Marc A Antonyak

    Published 10 April 2023

    Glioma patients often relapse because of resistance to radiation therapy. The transfer of the metabolic enzyme NAMPT via microvesicles and the accompanying elevated levels of NAD are found to be a mechanism by which glioma cells become resistant to radiation.

  • An OMA1 redox site controls mitochondrial homeostasis, sarcoma growth, and immunogenicity
    Open Access
    An OMA1 redox site controls mitochondrial homeostasis, sarcoma growth, and immunogenicity

    Richard Miallot, Virginie Millet, Yann Groult, Angelika Modelska, Lydie Crescence, Sandrine Roulland, Sandrine Henri, Bernard Malissen, Nicolas Brouilly, Laurence Panicot-Dubois, Renaud Vincentelli, Gerlind Sulzenbacher, Pascal Finetti, Aurélie Dutour, Jean-Yves Blay, François Bertucci, Franck Galland, Philippe Naquet

    Richard Miallot ... Philippe Naquet

    Published 5 April 2023

    This work describes how a mutation affecting mitochondrial metabolism in a sarcoma model induces protective immunity against the tumor and how this result might be relevant for sarcoma patients.

  • Endemic Burkitt lymphoma avatar mouse models for exploring inter-patient tumor variation and testing targeted therapies
    Open Access
    Endemic Burkitt lymphoma avatar mouse models for exploring inter-patient tumor variation and testing targeted therapies

    Priya Saikumar Lakshmi, Cliff I Oduor, Catherine S Forconi, Viriato M’Bana, Courtney Bly, Rachel M Gerstein, Juliana A Otieno, John M Ong’echa, Christian Münz, Micah A Luftig, Michael A Brehm, Jeffrey A Bailey, Ann M Moormann

    Priya Saikumar Lakshmi ... Ann M Moormann

    Published 6 March 2023

    Patient-derived tumor models show promise for evaluating novel cancer treatments that could improve outcomes for African children diagnosed with EBV-associated endemic Burkitt lymphoma.

  • RAS and PP2A activities converge on epigenetic gene regulation
    Open Access
    RAS and PP2A activities converge on epigenetic gene regulation

    Anna Aakula, Mukund Sharma, Francesco Tabaro, Reetta Nätkin, Jesse Kamila, Henrik Honkanen, Matthieu Schapira, Cheryl Arrowsmith, Matti Nykter, Jukka Westermarck

    Anna Aakula ... Jukka Westermarck

    Published 1 March 2023

    This study reveals a hidden regulatory layer in epigenetic gene expression in cancer by co-operative phosphoregulation by RAS and tumor suppressor phosphatase PP2A.

  • Three-dimensional growth reveals fine-tuning of 5-lipoxygenase by proliferative pathways in cancer
    Open Access
    Three-dimensional growth reveals fine-tuning of 5-lipoxygenase by proliferative pathways in cancer

    Tamara Göbel, Bjarne Goebel, Marius Hyprath, Ira Lamminger, Hannah Weisser, Carlo Angioni, Marius Mathes, Dominique Thomas, Astrid S Kahnt

    Tamara Göbel ... Astrid S Kahnt

    Published 27 February 2023

    The expression of 5-lipoxygenase, the key enzyme in leukotriene biosynthesis, is suppressed in proliferating cancer cells by a PI3K/mTORC-2– and MEK-1/ERK-dependent axis involving E2F1 and b-Myb.

  • AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation
    Open Access
    AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation

    Italia Anna Asteriti, Federica Polverino, Venturina Stagni, Valentina Sterbini, Camilla Ascanelli, Francesco Davide Naso, Anna Mastrangelo, Alessandro Rosa, Alessandro Paiardini, Catherine Lindon, Giulia Guarguaglini

    Italia Anna Asteriti ... Giulia Guarguaglini

    Published 16 February 2023

    This study shows that TPX2 co-overexpression in non-transformed human cells induces AurkA nuclear accumulation and promotes its non-mitotic oncogenic functions.

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