Cancer
KIF13B-mediated VEGFR2 trafficking is essential for vascular leakage and metastasis in vivoThe cancer cells secrete VEGF, which induces vascular leakage and metastasis. Inhibition of VEGFR2 trafficking to the cell surface prevents receiving VEGF, vascular leakage, and cancer metastasis.
Kinomics platform using GBM tissue identifies BTK as being associated with higher patient survivalBTK is a dominant bioactive kinase expressed within both cancer and immune cells of GBM tissue. Complex cell co-cultures might better model the impact of kinase inhibitors as therapeutics in GBM.
Suppression of isoprenylcysteine carboxylmethyltransferase compromises DNA damage repairInhibition of isoprenylcysteine carboxylmethyltransferase reduces cancer cells’ ability to repair DNA damage by suppressing the expression of critical DNA damage repair pathway genes, hence increasing their vulnerability to DNA damaging insults such as PARP inhibitors and other DNA damage agents.
Paralogous synthetic lethality underlies genetic dependencies of the cancer-mutated gene STAG2The context-dependency of genetic interactions of the cohesin gene STAG2, specifically STAG1 and the iron regulatory gene IREB2, are revealed by CRISPR-Cas9 screening in three different cellular backgrounds.
Extracellular matrix mediates moruloid-blastuloid morphodynamics in malignant ovarian spheroidsExpression dynamics of basement membrane-like extracellular matrix and fibronectin regulate transitions between solid (moruloid) and cavitational (blastuloid) phenotypes of ovarian cancer spheroids.
Dendritic cells maintain anti-tumor immunity by positioning CD8 skin-resident memory T cellsTissue-resident memory (TRM) T cells in mouse and human melanoma-associated vitiligo skin form large lymphoid aggregates with CXCL16-expressing dendritic cells. CD11c depletion or disruption of the CXCR6-CXCL16 axis results in loss of skin TRM cells and tumor immunity.
Hepatitis B virus compartmentalization and single-cell differentiation in hepatocellular carcinomaSingle-cell RNA-Seq unravels heterogeneity and compartmentalization of both hepatitis B virus and cancer identifying new candidate pathways for viral hepatocarcinogenesis.
Functional annotation of noncoding mutations in cancerRecurrent regulatory mutations affecting transcription factor binding sites in 2,500 cancer samples.
Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancerThis work identifies the use of exosomes to specifically deliver CRISPR/Cas9 to target oncogenic KrasG12D mutation in pancreatic cancer as a nonviral therapeutic strategy.
The stabilized Pol31–Pol3 interface counteracts Pol32 ablation with differential effects on repairDNA pol δ is needed for lagging strand replication and DNA repair. We shed light on both distinct and common roles of the second and third subunits, Pol31 and Pol32, in S-phase linked repair pathways.