Biophysics
Atomic force microscopy reveals structural variability amongst nuclear pore complexesStructural heterogeneity is resolved in isolated nuclear envelopes, revealing the lamina network and nuclear pore complexes of different sizes, as well as different morphologies in their transport barrier and different binding of nuclear transport receptors in the barrier.
Beetle luciferases with naturally red- and blue-shifted emissionNew crystal structures of red- and green blue–shifted beetle luciferases reveal that the color emission mechanism is dependent on the active site microenvironment affected by the conformation of loop regions.
Co-existing feedback loops generate tissue-specific circadian rhythmsThe analysis of tissue-specific data-based models of the gene regulatory network of the mammalian circadian clock reveals organ-specific synergies of feedback loops.
Ribosome recycling is coordinated by processive events in two asymmetric ATP sites of ABCE1The stepwise ribosome disassembly in the translation cycle of eukaryotes and archaea is scheduled by discrete molecular events within the asymmetric ribosome recycling factor ABCE1.