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Biophysics

  • Atomic force microscopy reveals structural variability amongst nuclear pore complexes
    Open Access
    Atomic force microscopy reveals structural variability amongst nuclear pore complexes

    George J Stanley, Ariberto Fassati, Bart W Hoogenboom

    George J Stanley ... Bart W Hoogenboom

    Published 20 August 2018

    Structural heterogeneity is resolved in isolated nuclear envelopes, revealing the lamina network and nuclear pore complexes of different sizes, as well as different morphologies in their transport barrier and different binding of nuclear transport receptors in the barrier.

  • Beetle luciferases with naturally red- and blue-shifted emission
    Open Access
    Beetle luciferases with naturally red- and blue-shifted emission

    César Carrasco-López, Juliana C Ferreira, Nathan M Lui, Stefan Schramm, Romain Berraud-Pache, Isabelle Navizet, Santosh Panjikar, Panče Naumov, Wael M Rabeh

    César Carrasco-López ... Wael M Rabeh

    Published 16 August 2018

    New crystal structures of red- and green blue–shifted beetle luciferases reveal that the color emission mechanism is dependent on the active site microenvironment affected by the conformation of loop regions.

  • Co-existing feedback loops generate tissue-specific circadian rhythms
    Open Access
    Co-existing feedback loops generate tissue-specific circadian rhythms

    J Patrick Pett, Matthew Kondoff, Grigory Bordyugov, Achim Kramer, Hanspeter Herzel

    J Patrick Pett ... Hanspeter Herzel

    Published 14 June 2018

    The analysis of tissue-specific data-based models of the gene regulatory network of the mammalian circadian clock reveals organ-specific synergies of feedback loops.

  • Ribosome recycling is coordinated by processive events in two asymmetric ATP sites of ABCE1
    Open Access
    Ribosome recycling is coordinated by processive events in two asymmetric ATP sites of ABCE1

    Elina Nürenberg-Goloub, Holger Heinemann, Milan Gerovac, Robert Tampé

    Elina Nürenberg-Goloub ... Robert Tampé

    Published 14 June 2018

    The stepwise ribosome disassembly in the translation cycle of eukaryotes and archaea is scheduled by discrete molecular events within the asymmetric ribosome recycling factor ABCE1.

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