Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Archive
    • Subjects
  • Submit
    • Submit a Manuscript
    • Author Guidelines
    • License, Copyright, Fee
    • FAQ
    • Why Submit
  • About
    • About Us
    • Editors & Staff
    • Board Members
    • Licensing and Reuse
    • Reviewer Guidelines
    • Privacy Policy
    • Advertise
    • Contact Us
    • LSA LLC
  • Alerts
  • Other Publications
    • EMBO Press
    • The EMBO Journal
    • EMBO reports
    • EMBO Molecular Medicine
    • Molecular Systems Biology
    • Rockefeller University Press
    • Journal of Cell Biology
    • Journal of Experimental Medicine
    • Journal of General Physiology
    • Cold Spring Harbor Laboratory Press
    • Genes & Development
    • Genome Research

User menu

  • My alerts

Search

  • Advanced search
Life Science Alliance
  • Other Publications
    • EMBO Press
    • The EMBO Journal
    • EMBO reports
    • EMBO Molecular Medicine
    • Molecular Systems Biology
    • Rockefeller University Press
    • Journal of Cell Biology
    • Journal of Experimental Medicine
    • Journal of General Physiology
    • Cold Spring Harbor Laboratory Press
    • Genes & Development
    • Genome Research
  • My alerts
Life Science Alliance

Advanced Search

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Archive
    • Subjects
  • Submit
    • Submit a Manuscript
    • Author Guidelines
    • License, Copyright, Fee
    • FAQ
    • Why Submit
  • About
    • About Us
    • Editors & Staff
    • Board Members
    • Licensing and Reuse
    • Reviewer Guidelines
    • Privacy Policy
    • Advertise
    • Contact Us
    • LSA LLC
  • Alerts
  • Follow lsa Template on Twitter

Biophysics

  • Stoichiometry of Rtt109 complexes with Vps75 and histones H3-H4
    Open Access
    Stoichiometry of Rtt109 complexes with Vps75 and histones H3-H4

    Noushin Akhavantabib, Daniel D Krzizike, Victoria Neumann, Sheena D’Arcy

    Noushin Akhavantabib ... Sheena D’Arcy

    Published 10 September 2020

    The work determines the relative and absolute stoichiometry of a 5-chain protein complex involved in histone chaperoning and acetylation. Using sedimentation velocity and light scattering, it uncovers a dynamic equilibrium of complex self-association.

  • MERLIN: a novel BRET-based proximity biosensor for studying mitochondria–ER contact sites
    Open Access
    MERLIN: a novel BRET-based proximity biosensor for studying mitochondria–ER contact sites

    Vanessa Hertlein, Hector Flores-Romero, Kushal K Das, Sebastian Fischer, Michael Heunemann, Maria Calleja-Felipe, Shira Knafo, Katharina Hipp, Klaus Harter, Julia C Fitzgerald, Ana J García-Sáez

    Vanessa Hertlein ... Ana J García-Sáez

    Published 9 December 2019

    MERLIN is a novel biosensor that generates a BRET signal with a signal-to-noise ratio that is sufficient to enable sensing the proximity between the mitochondria and the ER without forcing interaction or establishing artificial connections at the MERCs.

  • Resolving kinesin stepping: one head at a time
    Open Access
    Resolving kinesin stepping: one head at a time

    Willi L Stepp, Zeynep Ökten

    Willi L Stepp ... Zeynep Ökten

    Published 10 October 2019

    This study shows for the first time a qualitative difference in the stepping of a heterodimeric motor and the asymmetric influence of autoinhibition on the stepping of one of the heads.

  • Plasmalogen loss caused by remodeling deficiency in mitochondria
    Open Access
    Plasmalogen loss caused by remodeling deficiency in mitochondria

    Tomohiro Kimura, Atsuko K Kimura, Mindong Ren, Vernon Monteiro, Yang Xu, Bob Berno, Michael Schlame, Richard M Epand

    Tomohiro Kimura ... Richard M Epand

    Published 21 August 2019

    31P NMR unveils cell type–dependent losses of plasmalogen in the chain remodeling–deficient brain, liver, kidney, and lymphoblast in association with aberrant mitochondrial function and morphology.

  • KAP1 is an antiparallel dimer with a functional asymmetry
    Open Access
    KAP1 is an antiparallel dimer with a functional asymmetry

    Giulia Fonti, Maria J Marcaida, Louise C Bryan, Sylvain Träger, Alexandra S Kalantzi, Pierre-Yves JL Helleboid, Davide Demurtas, Mark D Tully, Sergei Grudinin, Didier Trono, Beat Fierz, Matteo Dal Peraro

    Giulia Fonti ... Matteo Dal Peraro

    Published 19 August 2019

    This study reveals the architecture of human KAP1 by integrating molecular modeling with small-angle X-ray scattering and single-molecule experiments. KAP1 dimers feature a structural asymmetry at the C-terminal domains that has functional implications for recruitment of HP1.

  • PRDM9 forms a trimer by interactions within the zinc finger array
    Open Access
    PRDM9 forms a trimer by interactions within the zinc finger array

    Theresa Schwarz, Yasmin Striedner, Andreas Horner, Karin Haase, Jasmin Kemptner, Nicole Zeppezauer, Philipp Hermann, Irene Tiemann-Boege

    Theresa Schwarz ... Irene Tiemann-Boege

    Published 15 July 2019

    PRDM9 forms a trimer as a soluble protein and in complex with DNA mediated by the ZnF domain. Five ZnFs are already sufficient for multimerization and only one DNA molecule is complexed in the trimer.

  • ATP hydrolysis by KaiC promotes its KaiA binding in the cyanobacterial circadian clock system
    Open Access
    ATP hydrolysis by KaiC promotes its KaiA binding in the cyanobacterial circadian clock system

    Yasuhiro Yunoki, Kentaro Ishii, Maho Yagi-Utsumi, Reiko Murakami, Susumu Uchiyama, Hirokazu Yagi, Koichi Kato

    Yasuhiro Yunoki ... Koichi Kato

    Published 3 June 2019

    ATP hydrolysis in the KaiC hexamer triggers the exposure of its C-terminal segments into the solvent so as to capture KaiA, providing mechanistic insights into the circadian periodicity regulation.

  • Mesenchymal stromal cell activation by breast cancer secretomes in bioengineered 3D microenvironments
    Open Access
    Mesenchymal stromal cell activation by breast cancer secretomes in bioengineered 3D microenvironments

    Ulrich Blache, Edward R Horton, Tian Xia, Erwin M Schoof, Lene H Blicher, Angelina Schönenberger, Jess G Snedeker, Ivan Martin, Janine T Erler, Martin Ehrbar

    Ulrich Blache ... Martin Ehrbar

    Published 3 June 2019

    This study shows the activation of tumour-associated mesenchymal stromal cells by breast cancer secretomes in bioengineered 3D microenvironments using comprehensive multiomics analysis methods.

  • KIF18A's neck linker permits navigation of microtubule-bound obstacles within the mitotic spindle
    Open Access
    KIF18A's neck linker permits navigation of microtubule-bound obstacles within the mitotic spindle

    Heidi LH Malaby, Dominique V Lessard, Christopher L Berger, Jason Stumpff

    Heidi LH Malaby ... Jason Stumpff

    Published 17 January 2019

    The length of KIF18A's neck linker permits navigation of obstacles along K-fibers within the mitotic spindle and is required for the timely alignment and segregation of mitotic chromosomes.

  • Secretory granule protein chromogranin B (CHGB) forms an anion channel in membranes
    Open Access
    Secretory granule protein chromogranin B (CHGB) forms an anion channel in membranes

    Gaya P Yadav, Hui Zheng, Qing Yang, Lauren G Douma, Linda B Bloom, Qiu-Xing Jiang

    Gaya P Yadav ... Qiu-Xing Jiang

    Published 24 September 2018

    The CHGB subfamily of secretory granule proteins forms a new family of anion-selective channels by interacting with membranes via two amphipathic α-helices. The channel exhibits higher anion selectivity, larger conductance, higher DIDS-binding affinity, and higher Cl− sensitivity than other known anion channels.

Pages

  • Next
  • 1
  • 2
  • Aging (11)
  • Biophysics (14)
  • Cancer (71)
  • Cell Biology (157)
  • Chemical Biology (7)
  • Chromatin & Epigenetics (32)
  • Development (29)
  • Ecology (1)
  • Evolution (10)
  • Genetics, Gene Therapy & Genetic Disease (33)
  • Genomics & Functional Genomics (46)
  • Immunology (64)
  • Medical Research (31)
  • Metabolism (24)
  • Methods & Resources (26)
  • Microbiology, Virology & Host Pathogen Interaction (47)
  • Molecular Biology (102)
  • Molecular Diagnostics & Diagnostic Imaging (2)
  • Neuroscience (39)
  • Pharmacology & Biotechnology (8)
  • Physiology (11)
  • Plant Science (11)
  • Stem Cells (26)
  • Structural Biology (28)
  • Synthetic Biology (2)
  • Systems & Computational Biology (38)
Advertisement

EMBO Press LogoRockefeller University Press LogoCold Spring Harbor Logo

Content

  • Home
  • Newest Articles
  • Current Issue
  • Archive
  • Subject Collections

For Authors

  • Submit a Manuscript
  • Author Guidelines
  • License, copyright, Fee

Other Services

  • Alerts
  • Twitter
  • RSS Feeds

More Information

  • Editors & Staff
  • Reviewer Guidelines
  • Feedback
  • Licensing and Reuse
  • Privacy Policy

ISSN: 2575-1077
© 2021 Life Science Alliance LLC

Life Science Alliance is registered as a trademark in the U.S. Patent and Trade Mark Office and in the European Union Intellectual Property Office.