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Biophysics

  • Phospholipids alter activity and stability of mitochondrial membrane-bound ubiquitin ligase MARCH5
    Open Access
    Phospholipids alter activity and stability of mitochondrial membrane-bound ubiquitin ligase MARCH5

    Lisa Merklinger, Johannes Bauer, Per A Pedersen, Rune Busk Damgaard, J Preben Morth

    Lisa Merklinger ... J Preben Morth

    Published 22 April 2022

    This study shows that lipids can act as regulators for the ubiquitination process and can control the stability and activity of a membrane-embedded E3 ubiquitin ligase.

  • Structural basis of Nrd1–Nab3 heterodimerization
    Open Access
    Structural basis of Nrd1–Nab3 heterodimerization

    Belén Chaves-Arquero, Santiago Martínez-Lumbreras, Sergio Camero, Clara M Santiveri, Yasmina Mirassou, Ramón Campos-Olivas, Maria Ángeles Jiménez, Olga Calvo, José Manuel Pérez-Cañadillas

    Belén Chaves-Arquero ... José Manuel Pérez-Cañadillas

    Published 12 January 2022

    The NMR structure of an Nrd1–Nab3 chimera describes the structural bases of Nrd1/Nab3 heterodimerization. Nrd1 embraces a bundle of helices in Nab3, building a large interface. Key mutations at that interface compromise cell fitness.

  • New insights into the phosphorylation of the threonine motif of the β1 integrin cytoplasmic domain
    Open Access
    New insights into the phosphorylation of the threonine motif of the β1 integrin cytoplasmic domain

    Ralph T Böttcher, Nico Strohmeyer, Jonas Aretz, Reinhard Fässler

    Ralph T Böttcher ... Reinhard Fässler

    Published 7 January 2022

    This study investigates phosphorylation of and kindlin recruitment by the double-threonine motif in the β1 integrin cytoplasmic tails.

  • Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma
    Open Access
    Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma

    Matthias M Schneider, Marc Emmenegger, Catherine K Xu, Itzel Condado Morales, Georg Meisl, Priscilla Turelli, Chryssa Zografou, Manuela R Zimmermann, Beat M Frey, Sebastian Fiedler, Viola Denninger, Raphaël PB Jacquat, Lidia Madrigal, Alison Ilsley, Vasilis Kosmoliaptsis, Heike Fiegler, Didier Trono, Tuomas PJ Knowles, Adriano Aguzzi

    Matthias M Schneider ... Adriano Aguzzi

    Published 30 November 2021

    Using microfluidic affinity profiling, we show how the antibody affinity varies significantly between different individuals after COVID-19 infection while the antibodies neutralise the virus.

  • Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations
    Open Access
    Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations

    Urška Rovšnik, Yuxuan Zhuang, Björn O Forsberg, Marta Carroni, Linnea Yvonnesdotter, Rebecca J Howard, Erik Lindahl

    Urška Rovšnik ... Erik Lindahl

    Published 1 July 2021

    Cryo-EM structures and molecular simulations of a pentameric ligand-gated ion channel, GLIC, in resting and activating conditions implicate protonation sites and altered dynamics in sequential gating.

  • Stoichiometry of Rtt109 complexes with Vps75 and histones H3-H4
    Open Access
    Stoichiometry of Rtt109 complexes with Vps75 and histones H3-H4

    Noushin Akhavantabib, Daniel D Krzizike, Victoria Neumann, Sheena D’Arcy

    Noushin Akhavantabib ... Sheena D’Arcy

    Published 10 September 2020

    The work determines the relative and absolute stoichiometry of a 5-chain protein complex involved in histone chaperoning and acetylation. Using sedimentation velocity and light scattering, it uncovers a dynamic equilibrium of complex self-association.

  • MERLIN: a novel BRET-based proximity biosensor for studying mitochondria–ER contact sites
    Open Access
    MERLIN: a novel BRET-based proximity biosensor for studying mitochondria–ER contact sites

    Vanessa Hertlein, Hector Flores-Romero, Kushal K Das, Sebastian Fischer, Michael Heunemann, Maria Calleja-Felipe, Shira Knafo, Katharina Hipp, Klaus Harter, Julia C Fitzgerald, Ana J García-Sáez

    Vanessa Hertlein ... Ana J García-Sáez

    Published 9 December 2019

    MERLIN is a novel biosensor that generates a BRET signal with a signal-to-noise ratio that is sufficient to enable sensing the proximity between the mitochondria and the ER without forcing interaction or establishing artificial connections at the MERCs.

  • Resolving kinesin stepping: one head at a time
    Open Access
    Resolving kinesin stepping: one head at a time

    Willi L Stepp, Zeynep Ökten

    Willi L Stepp ... Zeynep Ökten

    Published 10 October 2019

    This study shows for the first time a qualitative difference in the stepping of a heterodimeric motor and the asymmetric influence of autoinhibition on the stepping of one of the heads.

  • Plasmalogen loss caused by remodeling deficiency in mitochondria
    Open Access
    Plasmalogen loss caused by remodeling deficiency in mitochondria

    Tomohiro Kimura, Atsuko K Kimura, Mindong Ren, Vernon Monteiro, Yang Xu, Bob Berno, Michael Schlame, Richard M Epand

    Tomohiro Kimura ... Richard M Epand

    Published 21 August 2019

    31P NMR unveils cell type–dependent losses of plasmalogen in the chain remodeling–deficient brain, liver, kidney, and lymphoblast in association with aberrant mitochondrial function and morphology.

  • KAP1 is an antiparallel dimer with a functional asymmetry
    Open Access
    KAP1 is an antiparallel dimer with a functional asymmetry

    Giulia Fonti, Maria J Marcaida, Louise C Bryan, Sylvain Träger, Alexandra S Kalantzi, Pierre-Yves JL Helleboid, Davide Demurtas, Mark D Tully, Sergei Grudinin, Didier Trono, Beat Fierz, Matteo Dal Peraro

    Giulia Fonti ... Matteo Dal Peraro

    Published 19 August 2019

    This study reveals the architecture of human KAP1 by integrating molecular modeling with small-angle X-ray scattering and single-molecule experiments. KAP1 dimers feature a structural asymmetry at the C-terminal domains that has functional implications for recruitment of HP1.

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