Most read article(s)
- Inhibition of a transcriptional repressor rescues hearing in a splicing factor–deficient mouse
The vital role of the splicing factor SRRM4 in vestibular and inner hair cells of the ear is inactivation of the gene repressor REST; however, in outer hair cells, SRRM4 is dispensable for REST inactivation, which SRRM3 accomplishes independently.
- Micronucleus is not a potent inducer of the cGAS/STING pathway
The FuVis2 reporter system, designed to visualize cell nuclei harboring sister chromatid fusion, equipped with cGAS/STING reporters, offers critical insights that micronuclei are primarily captured by cGAS during mitosis but do not lead to STING activation.
- Epigenomic states contribute to coordinated allelic transcriptional bursting in iPSC reprogramming
Epigenomic states are linked to the coordinated allelic transcriptional bursting of genes involved in iPSC reprogramming.
- Stability of gut microbiome after COVID-19 vaccination in healthy and immuno-compromised individuals
This study highlights the resilience of the gut microbiome to host immune changes triggered by COVID-19 vaccination and suggest minimal, if any, impact on microbiome-mediated processes.
- NeoMUST: an accurate and efficient multi-task learning model for neoantigen presentation
NeoMUST, a multi-task learning model, efficiently predicts neoantigen presentation via MHC-I molecules, rivaling existing algorithms with significantly shorter training time. Its GitHub repository offers free access for advancing cancer immunotherapy development.
- Fibro-adipogenic progenitors of dystrophic mice are insensitive to NOTCH regulation of adipogenesis
The NOTCH pathway, in concert with TNFa, restrains adipogenesis of muscle fibro-adipogenic progenitors (FAPs). Dystrophin-deficient FAPs are less sensitive to NOTCH anti-adipogenic signals, thus explaining why fat infiltrations are solely observed in the muscles of dystrophic individuals.
- Main constraints for RNAi induced by expressed long dsRNA in mouse cells
A systematic survey of dsRNA expression in mouse fibroblasts and embryonic stem cells shows main constraints for RNAi. RNAi activity depends on the initial Dicer cleavage of dsRNA, having implications for the evolution of mammalian RNAi functions.
- A feedback loop that drives cell death and proliferation and its defect in intestinal stem cells
A positive feedback circuit that simultaneously drives cell death and proliferation and its defect in intestinal stem cells in Drosophila were discovered.
- Genome-wide CRISPR screen reveals the synthetic lethality between BCL2L1 inhibition and radiotherapy
Unbiased whole-genome CRISPR/Cas9 screening reveals that loss of BCL2L1 shows synthetic lethality with radiation, which is further confirmed with the use of BCL2L1 inhibitor. Thus, radiation plus inhibitors targeting BCL2 family proteins is a promising combination therapy for cancers.
- Cholesterol and COVID-19—therapeutic opportunities at the host/virus interface during cell entry
The key to cholesterol-related broad-spectrum antiviral strategies may be to disrupt cholesterol handling in specific cellular organelles.