Most read article(s)
- Ageing-dependent thiol oxidation reveals early oxidation of proteins with core proteostasis functions
Proteome-wide analysis of thiol oxidation during chronological ageing of yeast reveals evolutionarily conserved proteins as early-oxidation targets with a potential impact on proteostasis regulation.
- TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells
The spike protein S of SARS-CoV-2 is activated by TMPRSS2 and furin. Inhibition of either one of these proteases can render the S protein unable to mediate virus entry and, therefore, provides a promising approach for COVID-19 treatment.
- Identification of human gene research articles with wrongly identified nucleotide sequences
This study describes Seek & Blastn analysis of targeted and journal corpora with manual results verification to identify human gene research articles with wrongly identified nucleotide sequence reagents.
- Breast implant surface topography triggers a chronic-like inflammatory response
This study explores the impact of breast implant surface topographies on immune responses, using analyses of periprosthetic fluids and in vitro cultures on model surface replicas, revealing that macrotextured implants significantly induce chronic-like inflammatory reactions.
- Galectin-8 modulates human osteoclast activity partly through isoform-specific interactions
Galectin-8 is emerging as a key player in osteoclastic bone resorption. Explore the specific functions of its isoforms through interactome analysis, revealing intricate mechanisms of bone biology.
- SHIP1 deficiency causes inflammation-dependent retardation in skeletal growth
SHIP1 plays a cell-intrinsic role in osteoclast function and development, yet skeletal growth retardation in SHIP1-deficient mice is dependent on lymphocyte-induced inflammation.
- Linking medicinal cannabis to autotaxin–lysophosphatidic acid signaling
The authors show that Δ9-trans-tetrahydrocannabinol, the main psychoactive compound in medicinal cannabis, could be considered as a therapeutic agent by inhibiting autotaxin–lysophosphatidic acid production.
- multicrispr: gRNA design for prime editing and parallel targeting of thousands of targets
A bioinformatics R package for a fast and generic guideRNA design, optimized for large-scale perturbation assays.
- The Rtf1/Prf1-dependent histone modification axis counteracts multi-drug resistance in fission yeast
Mutations in a conserved histone modification axis confer a unique drug-tolerant phenotype in fission yeast, and suggest a mode of gene regulation shared with the Rpb1 C-terminal domain.
- Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancer
This work identifies the use of exosomes to specifically deliver CRISPR/Cas9 to target oncogenic KrasG12D mutation in pancreatic cancer as a nonviral therapeutic strategy.