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Redundant roles of EGFR ligands in the ERK activation waves during collective cell migrationBy knocking out all four EGFR ligands expressed in MDCK cells, this study shows the redundant and specific roles of each EGFR ligand in the ERK activation waves during collective cell migration.
TICAM-1/TRIF associates with Act1 and suppresses IL-17 receptor–mediated inflammatory responsesTICAM-1/TRIF, a TLR3 adaptor molecule, associates with Act1 to inhibit the interaction between IL-17RA and Act1, resulting in attenuated IL-17-mediated inflammatory responses.
Existence of log-phase Escherichia coli persisters and lasting memory of a starvation pulseThe authors characterize the growth condition dependence of survival of bacteria exposed to lethal antibiotics for a week. 1-h starvation pulse is shown to cause an increase in survival for days.
Poly(ADP-ribosyl)ating pathway regulates development from stem cell niche to longevity controlThe phosphorylation of poly(ADP-risobyl) glycohydrolase is involved in stem-cells differentiation, embryonic/larval development, regulation of longevity and fertility by calorie restriction.
Detecting sequence signals in targeting peptides using deep learningDuring the development of TargetP 2.0, a state-of-the-art method to predict targeting signal, we find a previously overlooked biological signal for subcellular targeting using the output from a deep learning method.
Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germlineA TPP1 mutation known to cause telomere shortening and bone marrow failure in humans recapitulates telomere loss but results in severe germline defects in mice without impacting murine hematopoiesis.
Loss of Resf1 reduces the efficiency of embryonic stem cell self-renewal and germline entryRESF1 supports ESC self-renewal by raising expression of transmembrane LIF receptor and key pluripotency transcription factors and increases in vitro primordial germ cell differentiation efficiency.
Suppression of isoprenylcysteine carboxylmethyltransferase compromises DNA damage repairInhibition of isoprenylcysteine carboxylmethyltransferase reduces cancer cells’ ability to repair DNA damage by suppressing the expression of critical DNA damage repair pathway genes, hence increasing their vulnerability to DNA damaging insults such as PARP inhibitors and other DNA damage agents.
The DREAM complex represses growth in response to DNA damage in ArabidopsisThis work presents composition, associated proteins, and topological aspects of the DREAM complex in plants and links to the DNA damage response by protein interaction data and mutant analysis.
Structural basis of membrane recognition of Toxoplasma gondii vacuole by Irgb6Upon Toxoplasma gondii infection, Irgb6 is recruited to the parasitophorous vacuole membrane (PVM) where Irgb6 disrupts it. We solved the atomic structures of Irgb6 in two distinct nucleotide states, revealing a unique PVM-binding interface sensitive to GTPase cycling.