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Intensive single-cell analysis reveals immune-cell diversity among healthy individualsThis study describes the diversity of the immune-cell profiling in healthy adults at the single-cell level using RNA-seq, VDJ repertoires, and proteome.
1,6-hexanediol rapidly immobilizes and condenses chromatin in living human cellsAlcohol, 1,6-hexanediol, is widely used for melting liquid droplets formed by liquid0–liquid phase separation; however, it can also seriously affect cells by immobilizing and condensing chromatin.
LncRNA RUS shapes the gene expression program towards neurogenesisThe chromatin-associated lncRNA RUS binds in the vicinity to neural differentiation-associated genes and regulates them in a context-dependent manner to enable proper neuron development.
A paralog-specific role of COPI vesicles in the neuronal differentiation of mouse pluripotent cellsThe paralogous COPI coat subunit γ1-COP plays a unique role in promoting neurite outgrowth during the neuronal differentiation of mouse pluripotent cells.
DNA methylation–independent long-term epigenetic silencing with dCRISPR/Cas9 fusion proteinsLong-term epigenetic gene silencing can be induced independently of DNA methylation by dCas9-KRABd-MeCP2 fusion proteins.
ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathwayESCRT-I deficiency impairs lysosome membrane turnover and induces homeostatic responses to lysosomal nutrient starvation including activation of MiT-TFE signaling caused by inhibition of the substrate-specific mTORC1 pathway.
FIREWORKS: a bottom-up approach to integrative coessentiality network analysisA tool to create bias-adjusted coessentiality networks reveals functional relationships between genes, context-specific rewiring of genetic networks, determinants of essentiality, and therapeutic targets for challenging proteins.
PRMT1 is required for the generation of MHC-associated microglia and remyelination in the central nervous systemPRMT1 regulates MHC-associated microglia cluster during de/remyelination.
Obesity-induced senescent macrophages activate a fibrotic transcriptional program in adipocyte progenitorsThis study demonstrates that senescent CD9+ macrophages in obese visceral fat of mice secrete osteopontin that promotes ECM deposition by adipogenic progenitor cells expressing Pdgfra and Pdgfrb.
VDAC1 negatively regulates melanogenesis through the Ca2+-calcineurin-CRTC1-MITF pathwayThis study revealed an important and novel role of mitochondrial VDAC1 in regulating melanogenesis in resting melanocytes through a Ca2+-regulated pathway that is independent of the alpha-MSH/UVB pathway.