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Most read article(s)

  • Intensive single-cell analysis reveals immune-cell diversity among healthy individuals
    Open Access
    Intensive single-cell analysis reveals immune-cell diversity among healthy individuals

    Yukie Kashima, Keiya Kaneko, Patrick Reteng, Nina Yoshitake, Lucky Ronald Runtuwene, Satoi Nagasawa, Masaya Onishi, Masahide Seki, Ayako Suzuki, Sumio Sugano, Mamiko Sakata-Yanagimoto, Yumiko Imai, Kaori Nakayama-Hosoya, Ai Kawana-Tachikawa, Taketoshi Mizutani, Yutaka Suzuki

    Yukie Kashima ... Yutaka Suzuki

    Published 5 April 2022

    This study describes the diversity of the immune-cell profiling in healthy adults at the single-cell level using RNA-seq, VDJ repertoires, and proteome.

  • 1,6-hexanediol rapidly immobilizes and condenses chromatin in living human cells
    Open Access
    1,6-hexanediol rapidly immobilizes and condenses chromatin in living human cells

    Yuji Itoh, Shiori Iida, Sachiko Tamura, Ryosuke Nagashima, Kentaro Shiraki, Tatsuhiko Goto, Kayo Hibino, Satoru Ide, Kazuhiro Maeshima

    Yuji Itoh ... Kazuhiro Maeshima

    Published 3 February 2021

    Alcohol, 1,6-hexanediol, is widely used for melting liquid droplets formed by liquid0–liquid phase separation; however, it can also seriously affect cells by immobilizing and condensing chromatin.

  • LncRNA <em>RUS</em> shapes the gene expression program towards neurogenesis
    Open Access
    LncRNA RUS shapes the gene expression program towards neurogenesis

    Marius F Schneider, Veronika Müller, Stephan A Müller, Stefan F Lichtenthaler, Peter B Becker, Johanna C Scheuermann

    Marius F Schneider ... Johanna C Scheuermann

    Published 10 June 2022

    The chromatin-associated lncRNA RUS binds in the vicinity to neural differentiation-associated genes and regulates them in a context-dependent manner to enable proper neuron development.

  • A paralog-specific role of COPI vesicles in the neuronal differentiation of mouse pluripotent cells
    Open Access
    A paralog-specific role of COPI vesicles in the neuronal differentiation of mouse pluripotent cells

    Manu Jain Goyal, Xiyan Zhao, Mariya Bozhinova, Karla Andrade-López, Cecilia de Heus, Sandra Schulze-Dramac, Michaela Müller-McNicoll, Judith Klumperman, Julien Béthune

    Manu Jain Goyal ... Julien Béthune

    Published 14 July 2020

    The paralogous COPI coat subunit γ1-COP plays a unique role in promoting neurite outgrowth during the neuronal differentiation of mouse pluripotent cells.

  • DNA methylation–independent long-term epigenetic silencing with dCRISPR/Cas9 fusion proteins
    Open Access
    DNA methylation–independent long-term epigenetic silencing with dCRISPR/Cas9 fusion proteins

    Li Ding, Lukas Theo Schmitt, Melanie Brux, Duran Sürün, Martina Augsburg, Felix Lansing, Jovan Mircetic, Mirko Theis, Frank Buchholz

    Li Ding ... Frank Buchholz

    Published 14 March 2022

    Long-term epigenetic gene silencing can be induced independently of DNA methylation by dCas9-KRABd-MeCP2 fusion proteins.

  • ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathway
    Open Access
    ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathway

    Marta Wróbel, Jarosław Cendrowski, Ewelina Szymańska, Malwina Grębowicz-Maciukiewicz, Noga Budick-Harmelin, Matylda Macias, Aleksandra Szybińska, Michał Mazur, Krzysztof Kolmus, Krzysztof Goryca, Michalina Dąbrowska, Agnieszka Paziewska, Michał Mikula, Marta Miączyńska

    Marta Wróbel ... Marta Miączyńska

    Published 30 March 2022

    ESCRT-I deficiency impairs lysosome membrane turnover and induces homeostatic responses to lysosomal nutrient starvation including activation of MiT-TFE signaling caused by inhibition of the substrate-specific mTORC1 pathway.

  • FIREWORKS: a bottom-up approach to integrative coessentiality network analysis
    Open Access
    FIREWORKS: a bottom-up approach to integrative coessentiality network analysis

    David R Amici, Jasen M Jackson, Mihai I Truica, Roger S Smith, Sarki A Abdulkadir, Marc L Mendillo

    David R Amici ... Marc L Mendillo

    Published 16 December 2020

    A tool to create bias-adjusted coessentiality networks reveals functional relationships between genes, context-specific rewiring of genetic networks, determinants of essentiality, and therapeutic targets for challenging proteins.

  • PRMT1 is required for the generation of MHC-associated microglia and remyelination in the central nervous system
    Open Access
    PRMT1 is required for the generation of MHC-associated microglia and remyelination in the central nervous system

    Jeesan Lee, Oscar David Villarreal, Yu Chang Wang, Jiannis Ragoussis, Serge Rivest, David Gosselin, Stéphane Richard

    Jeesan Lee ... Stéphane Richard

    Published 15 June 2022

    PRMT1 regulates MHC-associated microglia cluster during de/remyelination.

  • Obesity-induced senescent macrophages activate a fibrotic transcriptional program in adipocyte progenitors
    Open Access
    Obesity-induced senescent macrophages activate a fibrotic transcriptional program in adipocyte progenitors

    Nabil Rabhi, Kathleen Desevin, Anna C Belkina, Andrew Tilston-Lunel, Xaralabos Varelas, Matthew D Layne, Stephen R Farmer

    Nabil Rabhi ... Stephen R Farmer

    Published 18 February 2022

    This study demonstrates that senescent CD9+ macrophages in obese visceral fat of mice secrete osteopontin that promotes ECM deposition by adipogenic progenitor cells expressing Pdgfra and Pdgfrb.

  • VDAC1 negatively regulates melanogenesis through the Ca<sup>2+</sup>-calcineurin-CRTC1-MITF pathway
    Open Access
    VDAC1 negatively regulates melanogenesis through the Ca2+-calcineurin-CRTC1-MITF pathway

    Jianli Wang, Juanjuan Gong, Qiaochu Wang, Tieshan Tang, Wei Li

    Jianli Wang ... Wei Li

    Published 1 June 2022

    This study revealed an important and novel role of mitochondrial VDAC1 in regulating melanogenesis in resting melanocytes through a Ca2+-regulated pathway that is independent of the alpha-MSH/UVB pathway.

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