Most read article(s)
- Inhibiting the reproduction of SARS-CoV-2 through perturbations in human lung cell metabolic network
Using genomic and structural information from SARS-CoV-2, we created a biomass function capturing its amino and nucleic acid requirements and incorporated this into a metabolic model of the human lung cell to predict metabolic perturbations that inhibit virus reproduction.
- TrkB signaling regulates the cold-shock protein RBM3-mediated neuroprotection
The neuroprotective effects of the cold-shock protein RBM3 have broad appeal for therapy. RBM3 induction through cooling occurs through a non-canonical pattern of TrkB signaling. The pathway can now be targeted pharmacologically for RBM3-mediated neuroprotection without the need for cooling.
- Modulating HSF1 levels impacts expression of the estrogen receptor α and antiestrogen response
This work shows that activation of the main cellular stress response pathway is responsible for antiestrogen resistance in breast cancer, a process that is reversible.
- Predicting gene regulatory networks from cell atlases
Integrated single-cell gene regulatory network from three mouse cell atlases captures global and cell type–specific regulatory modules and crosstalk, important for cellular identity.
- RNA polymerase backtracking results in the accumulation of fission yeast condensin at active genes
Using both experiments and mathematical modelling, the authors show that RNA polymerase backtracking contributes to the accumulation of condensin in the termination zone of active genes.
- Human organotypic brain slice culture: a novel framework for environmental research in neuro-oncology
Therapeutically resected, adult brain segments were maintained and characterized for an extended period to study glioblastoma progression and treatment in its almost natural environment.
- The AXL-PYK2-PKCα axis as a nexus of stemness circuits in TNBC
A clinically relevant AXL-PYK2-PKCα axis where PYK2 and PKCα act as signaling nodes and functionally cooperate to converge stemness promoting pathways and regulate Oct4 and Nanog pluripotent TFs.
- RNase E cleavage shapes the transcriptome of Rhodobacter sphaeroides and strongly impacts phototrophic growth
This study identifies the cleavage sites of the endoribonuclease RNase E in the Rhodobacter sphaeroides transcriptome and demonstrates its effect on oxidative stress resistance and phototrophic growth.
- EBV renders B cells susceptible to HIV-1 in humanized mice
A proportion of EBV+ B cells are infectible by CXCR4-tropic HIV-1 in vitro and in vivo, and these HIV-infected B cells can transmit infection to previously virus-naïve humanized mice.
- MIC26 and MIC27 cooperate to regulate cardiolipin levels and the landscape of OXPHOS complexes
Apolipoproteins of MICOS, MIC26 and MIC27, cooperatively manage cristae structure, cardiolipin levels, and the global stability and integrity of respiratory chain supercomplexes and F1Fo–ATP synthase.