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Most read article(s)

  • Inhibiting the reproduction of SARS-CoV-2 through perturbations in human lung cell metabolic network
    Open Access
    Inhibiting the reproduction of SARS-CoV-2 through perturbations in human lung cell metabolic network

    Hadrien Delattre, Kalesh Sasidharan, Orkun S Soyer

    Hadrien Delattre ... Orkun S Soyer

    Published 24 November 2020

    Using genomic and structural information from SARS-CoV-2, we created a biomass function capturing its amino and nucleic acid requirements and incorporated this into a metabolic model of the human lung cell to predict metabolic perturbations that inhibit virus reproduction.

  • TrkB signaling regulates the cold-shock protein RBM3-mediated neuroprotection
    Open Access
    TrkB signaling regulates the cold-shock protein RBM3-mediated neuroprotection

    Diego Peretti, Heather L Smith, Nicholas Verity, Ibrahim Humoud, Lis de Weerd, Dean P Swinden, Joseph Hayes, Giovanna R Mallucci

    Diego Peretti ... Giovanna R Mallucci

    Published 9 February 2021

    The neuroprotective effects of the cold-shock protein RBM3 have broad appeal for therapy. RBM3 induction through cooling occurs through a non-canonical pattern of TrkB signaling. The pathway can now be targeted pharmacologically for RBM3-mediated neuroprotection without the need for cooling.

  • Modulating HSF1 levels impacts expression of the estrogen receptor α and antiestrogen response
    Open Access
    Modulating HSF1 levels impacts expression of the estrogen receptor α and antiestrogen response

    Maruhen AD Silveira, Christophe Tav, Félix-Antoine Bérube-Simard, Tania Cuppens, Mickaël Leclercq, Éric Fournier, Maxime C Côté, Arnaud Droit, Steve Bilodeau

    Maruhen AD Silveira ... Steve Bilodeau

    Published 16 February 2021

    This work shows that activation of the main cellular stress response pathway is responsible for antiestrogen resistance in breast cancer, a process that is reversible.

  • Predicting gene regulatory networks from cell atlases
    Open Access
    Predicting gene regulatory networks from cell atlases

    Andreas Fønss Møller, Kedar Nath Natarajan

    Andreas Fønss Møller ... Kedar Nath Natarajan

    Published 21 September 2020

    Integrated single-cell gene regulatory network from three mouse cell atlases captures global and cell type–specific regulatory modules and crosstalk, important for cellular identity.

  • RNA polymerase backtracking results in the accumulation of fission yeast condensin at active genes
    Open Access
    RNA polymerase backtracking results in the accumulation of fission yeast condensin at active genes

    Julieta Rivosecchi, Daniel Jost, Laetitia Vachez, François DR Gautier, Pascal Bernard, Vincent Vanoosthuyse

    Julieta Rivosecchi ... Vincent Vanoosthuyse

    Published 26 March 2021

    Using both experiments and mathematical modelling, the authors show that RNA polymerase backtracking contributes to the accumulation of condensin in the termination zone of active genes.

  • Human organotypic brain slice culture: a novel framework for environmental research in neuro-oncology
    Open Access
    Human organotypic brain slice culture: a novel framework for environmental research in neuro-oncology

    Vidhya M Ravi, Kevin Joseph, Julian Wurm, Simon Behringer, Nicklas Garrelfs, Paolo d’Errico, Yashar Naseri, Pamela Franco, Melanie Meyer-Luehmann, Roman Sankowski, Mukesch Johannes Shah, Irina Mader, Daniel Delev, Marie Follo, Jürgen Beck, Oliver Schnell, Ulrich G Hofmann, Dieter Henrik Heiland

    Vidhya M Ravi ... Dieter Henrik Heiland

    Published 27 June 2019

    Therapeutically resected, adult brain segments were maintained and characterized for an extended period to study glioblastoma progression and treatment in its almost natural environment.

  • The AXL-PYK2-PKCα axis as a nexus of stemness circuits in TNBC
    Open Access
    The AXL-PYK2-PKCα axis as a nexus of stemness circuits in TNBC

    Lohit Khera, Yaron Vinik, Flavio Maina, Sima Lev

    Lohit Khera ... Sima Lev

    Published 30 March 2021

    A clinically relevant AXL-PYK2-PKCα axis where PYK2 and PKCα act as signaling nodes and functionally cooperate to converge stemness promoting pathways and regulate Oct4 and Nanog pluripotent TFs.

  • RNase E cleavage shapes the transcriptome of <em>Rhodobacter sphaeroides</em> and strongly impacts phototrophic growth
    Open Access
    RNase E cleavage shapes the transcriptome of Rhodobacter sphaeroides and strongly impacts phototrophic growth

    Konrad U Förstner, Carina M Reuscher, Kerstin Haberzettl, Lennart Weber, Gabriele Klug

    Konrad U Förstner ... Gabriele Klug

    Published 1 August 2018

    This study identifies the cleavage sites of the endoribonuclease RNase E in the Rhodobacter sphaeroides transcriptome and demonstrates its effect on oxidative stress resistance and phototrophic growth.

  • EBV renders B cells susceptible to HIV-1 in humanized mice
    Open Access
    EBV renders B cells susceptible to HIV-1 in humanized mice

    Donal McHugh, Renier Myburgh, Nicole Caduff, Michael Spohn, Yik Lim Kok, Christian W Keller, Anita Murer, Bithi Chatterjee, Julia Rühl, Christine Engelmann, Obinna Chijioke, Isaak Quast, Mohaned Shilaih, Victoria P Strouvelle, Kathrin Neumann, Thomas Menter, Stephan Dirnhofer, Janice KP Lam, Kwai F Hui, Simon Bredl, Erika Schlaepfer, Silvia Sorce, Andrea Zbinden, Riccarda Capaul, Jan D Lünemann, Adriano Aguzzi, Alan KS Chiang, Werner Kempf, Alexandra Trkola, Karin J Metzner, Markus G Manz, Adam Grundhoff, Roberto F Speck, Christian Münz

    Donal McHugh ... Christian Münz

    Published 23 June 2020

    A proportion of EBV+ B cells are infectible by CXCR4-tropic HIV-1 in vitro and in vivo, and these HIV-infected B cells can transmit infection to previously virus-naïve humanized mice.

  • MIC26 and MIC27 cooperate to regulate cardiolipin levels and the landscape of OXPHOS complexes
    Open Access
    MIC26 and MIC27 cooperate to regulate cardiolipin levels and the landscape of OXPHOS complexes

    Ruchika Anand, Arun Kumar Kondadi, Jana Meisterknecht, Mathias Golombek, Oliver Nortmann, Julia Riedel, Leon Peifer-Weiß, Nahal Brocke-Ahmadinejad, David Schlütermann, Björn Stork, Thomas O Eichmann, Ilka Wittig, Andreas S Reichert

    Ruchika Anand ... Andreas S Reichert

    Published 11 August 2020

    Apolipoproteins of MICOS, MIC26 and MIC27, cooperatively manage cristae structure, cardiolipin levels, and the global stability and integrity of respiratory chain supercomplexes and F1Fo–ATP synthase.

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