Most read article(s)
- Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids
Here, the authors evaluate prime editing in human adult stem cell–derived organoids. TP53 mutations are modeled in hepatocyte and colon organoids and the clinical application of prime editing is evaluated by repairing mutations in CFTR without genome-wide off-targets.
- ATAD2 controls chromatin-bound HIRA turnover
Parallel study of multiple model systems points to the evolutionary conserved protein ATAD2, as a critical histone chaperone auxiliary factor.
- Metabolic and circadian inputs encode anticipatory biogenesis of hepatic fed microRNAs
Unravelling molecular and physiological mechanisms that couple circadian and metabolic cues to regulate anticipatory miR biogenesis during fed-fast-refed cycles in the liver.
- Knockout of PA200 improves proteasomal degradation and myelination in a proteotoxic neuropathy
Proteasome Activator 200 is upregulated in a neuropathy model in which protein degradation by the proteasome is impaired. Knocking out PA200 unexpectedly rescued proteostasis and prevented neuropathy.
- 2023 Reviewer Index
The LSA Editors thank these scientists for sharing their time and expertise while reviewing manuscripts in 2023. We sincerely appreciate their support.
- Galectin-8 modulates human osteoclast activity partly through isoform-specific interactions
Galectin-8 is emerging as a key player in osteoclastic bone resorption. Explore the specific functions of its isoforms through interactome analysis, revealing intricate mechanisms of bone biology.
- Tumor-intrinsic response to IFNγ shapes the tumor microenvironment and anti–PD-1 response in NSCLC
Using an immunocompetent mouse model of NSCLC, this study demonstrates that tumor-intrinsic response to IFNγ determines response to anti–PD-1 through alterations in the tumor microenvironment.
- Identification of human gene research articles with wrongly identified nucleotide sequences
This study describes Seek & Blastn analysis of targeted and journal corpora with manual results verification to identify human gene research articles with wrongly identified nucleotide sequence reagents.
- A practical comparison of the next-generation sequencing platform and assemblers using yeast genome
This research analyzes the general and optimal de novo yeast assembly pipeline using the repetitive yeast genome assembly by benchmarking four different sequencing platforms and seven assembly programs.
- Concordance of MERFISH spatial transcriptomics with bulk and single-cell RNA sequencing
Single-cell RNA-seq is an important technology for capturing gene expression in individual cells. It has limitations as spatial context and accurate representation of cell types in the tissue are lost. Here, we show that MERFISH is comparable to scRNA-seq.