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RFWD3 and translesion DNA polymerases contribute to PCNA modification–dependent DNA damage toleranceRFWD3 and the translesion DNA polymerases Polκ and Polη, for illudin S and UV DNA lesions, respectively, contribute to PCNA ubiquitination–dependent DNA damage tolerance in human cells.
Analyzing efficacy, stability, and safety of AAV-mediated optogenetic hearing restoration in miceThis longitudinal study revealed stable expression of the fast-gating channelrhodopsin f-Chrimson in cochlear neurons of mice over at least 2 yr upon a single postnatal AAV dosing of the cochlea.
Dimerization of kringle 1 domain from hepatocyte growth factor/scatter factor provides a potent MET receptor agonistWe designed and characterized a potent full MET receptor agonist consisting of two recombinantly linked HGF/SF kringle 1 domains and demonstrated its potential in epithelial tissue regeneration.
Fungal mycelia and bacterial thiamine establish a mutualistic growth mechanismBacterial cells travel along fungal highway and pay thiamine as a toll to the fungus. Simultaneous spatial and metabolic interactions in communicating bacterial and fungal species establish a mutualism that facilitates them to obtain an environmental niche and nutrient.
PFKFB4 interacts with ICMT and activates RAS/AKT signaling-dependent cell migration in melanomaGlycolysis regulator PFKFB4 promotes cell migration in metastatic melanoma and normal melanocytes by a non-conventional glycolysis-independent function involving ICMT, RAS, and AKT signaling.
A paralog-specific role of COPI vesicles in the neuronal differentiation of mouse pluripotent cellsThe paralogous COPI coat subunit γ1-COP plays a unique role in promoting neurite outgrowth during the neuronal differentiation of mouse pluripotent cells.
The vacuole shapes the nucleus and the ribosomal DNA loop during mitotic delaysChromosome structuring and condensation is one of the main features of mitosis. Here, Matos-Perdomo et al show how the nuclear envelope reshapes around the vacuole to give rise to the outstanding ribosomal DNA loop in budding yeast.
Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do notGenetic differences between C57BL/6 substrains lead to different cardiovascular traits; a null mutation in Mylk3 likely causes cardiomyopathy in C57BL/6N mice, whereas C57BL/6J Nnt-null mice do not develop cardiomyopathy.
Efficacy of SARS-CoV-2 vaccination in patients with monoclonal gammopathies: A cross sectional studyUninfected multiple myeloma patients do not develop adequate immunity after SARS-COV-2 vaccination and will clearly benefit from tailored monitoring of immune responses after booster vaccine doses.
Ubiquitome profiling reveals a regulatory pattern of UPL3 with UBP12 on metabolic-leaf senescenceA landscape of UPL3-ubiquitinated proteins by ubiquitome profile indicates UPL3 interacting with UBP12 as a hub of regulator on proteolysis-independent regulation and proteolysis-dependent degradation.