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Most read article(s)

  • Phylogenetic profiling resolves early emergence of PRC2 and illuminates its functional core
    Open Access
    Phylogenetic profiling resolves early emergence of PRC2 and illuminates its functional core

    Abdoallah Sharaf, Mallika Vijayanathan, Miroslav Oborník, Iva Mozgová

    Abdoallah Sharaf ... Iva Mozgová

    Published 19 April 2022

    This study strengthens the support for PRC2 emergence before the diversification of eukaryotes, detects a common presence of E(z) and ESC, indicating a conserved core, identifies diverse VEFS-Box Su(z)12 candidate proteins, and proposes a substrate specificity shift during E(z) evolution.

  • Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic Kras<sup>G12D</sup> in pancreatic cancer
    Open Access
    Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancer

    Kathleen M McAndrews, Fei Xiao, Antonios Chronopoulos, Valerie S LeBleu, Fernanda G Kugeratski, Raghu Kalluri

    Kathleen M McAndrews ... Raghu Kalluri

    Published 19 July 2021

    This work identifies the use of exosomes to specifically deliver CRISPR/Cas9 to target oncogenic KrasG12D mutation in pancreatic cancer as a nonviral therapeutic strategy.

  • 1,6-hexanediol rapidly immobilizes and condenses chromatin in living human cells
    Open Access
    1,6-hexanediol rapidly immobilizes and condenses chromatin in living human cells

    Yuji Itoh, Shiori Iida, Sachiko Tamura, Ryosuke Nagashima, Kentaro Shiraki, Tatsuhiko Goto, Kayo Hibino, Satoru Ide, Kazuhiro Maeshima

    Yuji Itoh ... Kazuhiro Maeshima

    Published 3 February 2021

    Alcohol, 1,6-hexanediol, is widely used for melting liquid droplets formed by liquid0–liquid phase separation; however, it can also seriously affect cells by immobilizing and condensing chromatin.

  • The hexosamine pathway and coat complex II promote malignant adaptation to nutrient scarcity
    Open Access
    The hexosamine pathway and coat complex II promote malignant adaptation to nutrient scarcity

    Helena Dragic, Audrey Barthelaix, Cédric Duret, Simon Le Goupil, Hadrien Laprade, Sophie Martin, Sabine Brugière, Yohann Couté, Christelle Machon, Jerome Guitton, Justine Rudewicz, Paul Hofman, Serge Lebecque, Cedric Chaveroux, Carole Ferraro-Peyret, Toufic Renno, Serge N Manié

    Helena Dragic ... Serge N Manié

    Published 8 April 2022

    We present adaptive mechanisms of resistance of lung adenocarcinoma to their harsh microenvironment, which typically contains a lower glucose concentration compared with normal tissue.

  • Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19
    Open Access
    Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19

    Jose F Varona, Pedro Landete, Jose A Lopez-Martin, Vicente Estrada, Roger Paredes, Pablo Guisado-Vasco, Lucia Fernandez de Orueta, Miguel Torralba, Jesus Fortun, Roberto Vates, Jose Barberan, Bonaventura Clotet, Julio Ancochea, Daniel Carnevali, Noemi Cabello, Lourdes Porras, Paloma Gijon, Alfonso Monereo, Daniel Abad, Sonia Zuñiga, Isabel Sola, Jordi Rodon, Julia Vergara-Alert, Nuria Izquierdo-Useros, Salvador Fudio, Maria Jose Pontes, Beatriz de Rivas, Patricia Giron de Velasco, Antonio Nieto, Javier Gomez, Pablo Aviles, Rubin Lubomirov, Alvaro Belgrano, Belen Sopesen, Kris M White, Romel Rosales, Soner Yildiz, Ann-Kathrin Reuschl, Lucy G Thorne, Clare Jolly, Greg J Towers, Lorena Zuliani-Alvarez, Mehdi Bouhaddou, Kirsten Obernier, Briana L McGovern, M Luis Rodriguez, Luis Enjuanes, Jose M Fernandez-Sousa, Nevan J Krogan, Jose M Jimeno, Adolfo Garcia-Sastre

    Jose F Varona ... Adolfo Garcia-Sastre

    Published 10 January 2022

    This proof-of-concept study shows that plitidepsin, a marine peptide that inhibits SARS-CoV-2 replication, has a favorable safety profile and may be an efficacious treatment for patients with COVID-19.

  • TET2-mediated epigenetic reprogramming of breast cancer cells impairs lysosome biogenesis
    Open Access
    TET2-mediated epigenetic reprogramming of breast cancer cells impairs lysosome biogenesis

    Audrey Laurent, Thierry Madigou, Maud Bizot, Marion Turpin, Gaëlle Palierne, Elise Mahé, Sarah Guimard, Raphaël Métivier, Stéphane Avner, Christine Le Péron, Gilles Salbert

    Audrey Laurent ... Gilles Salbert

    Published 29 March 2022

    TET2-mediated oxidation of 5-methylcytosine establishes an antiviral state and contributes to MYC-dependent down-regulation of genes involved in lysosome biogenesis and function in breast cancer cells.

  • A novel domain within the CIL regulates egress of IFITM3 from the Golgi and reveals a regulatory role of IFITM3 on the secretory pathway
    Open Access
    A novel domain within the CIL regulates egress of IFITM3 from the Golgi and reveals a regulatory role of IFITM3 on the secretory pathway

    Li Zhong, Yuxin Song, Federico Marziali, Rustem Uzbekov, Xuan-Nhi Nguyen, Chloé Journo, Philippe Roingeard, Andrea Cimarelli

    Li Zhong ... Andrea Cimarelli

    Published 8 April 2022

    In this work, it is revealed that the broad viral inhibitor IFITM3 is a previously unrecognized modulator of the functionalities of the cellular ER–Golgi secretory pathway.

  • Polycomb group ring finger protein 6 suppresses Myc-induced lymphomagenesis
    Open Access
    Polycomb group ring finger protein 6 suppresses Myc-induced lymphomagenesis

    Nina Tanaskovic, Mattia Dalsass, Marco Filipuzzi, Giorgia Ceccotti, Alessandro Verrecchia, Paola Nicoli, Mirko Doni, Daniela Olivero, Diego Pasini, Haruhiko Koseki, Arianna Sabò, Andrea Bisso, Bruno Amati

    Nina Tanaskovic ... Bruno Amati

    Published 14 April 2022

    Max dimerizes with Mga to form the repressive complex PRC1.6; another PRC1.6 subunit, Pcgf6, suppresses Myc-induced lymphomagenesis but, unexpectedly, does so in a Mga- and PRC1.6-independent manner.

  • Ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assembly
    Open Access
    Ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assembly

    Haruka Matsumori, Kenji Watanabe, Hiroaki Tachiwana, Tomoko Fujita, Yuma Ito, Makio Tokunaga, Kumiko Sakata-Sogawa, Hiroko Osakada, Tokuko Haraguchi, Akinori Awazu, Hiroshi Ochiai, Yuka Sakata, Koji Ochiai, Tsutomu Toki, Etsuro Ito, Ilya G Goldberg, Kazuaki Tokunaga, Mitsuyoshi Nakao, Noriko Saitoh

    Haruka Matsumori ... Noriko Saitoh

    Published 23 March 2022

    High content image analysis, single molecule tracking, modeling, and DBA patient analysis revealed that ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assembly.

  • Detecting sequence signals in targeting peptides using deep learning
    Open Access
    Detecting sequence signals in targeting peptides using deep learning

    Jose Juan Almagro Armenteros, Marco Salvatore, Olof Emanuelsson, Ole Winther, Gunnar von Heijne, Arne Elofsson, Henrik Nielsen

    Jose Juan Almagro Armenteros ... Henrik Nielsen

    Published 30 September 2019

    During the development of TargetP 2.0, a state-of-the-art method to predict targeting signal, we find a previously overlooked biological signal for subcellular targeting using the output from a deep learning method.

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