Most read article(s)
- Targeting circulating labile heme as a defense strategy against malaria
Malaria remains a major cause of human morbidity and mortality. Circulating labile heme is an independent risk factor for severe P. falciparum malaria, suggesting that labile heme may be a therapeutic target against severe malaria.
- Proteomics characterisation of the L929 cell supernatant and its role in BMDM differentiation
L929 cell supernatant is commonly used to differentiate murine macrophages from bone marrow. The supernatant and its effect on macrophage phenotype was characterised by proteomics and the authors identified novel immunoregulatory proteins.
- Zebrafish tsc1 and cxcl12a increase susceptibility to mycobacterial infection
Knockdown of miR-126 increases susceptibility to mycobacterial infection which can be independently reversed by targeting Tsc1/mTOR or ccr2 implicating macrophage function.
- Vamorolone targets dual nuclear receptors to treat inflammation and dystrophic cardiomyopathy
Vamorolone is a first-in-class dissociative drug that selectively targets the glucocorticoid receptor to safely treat chronic inflammation and the mineralocorticoid receptor to treat cardiomyopathy, providing efficacy with improved safety in mouse models of Duchenne muscular dystrophy.
- IFT88 maintains sensory function by localising signalling proteins along Drosophila cilia
DmIFT88 is dispensable to preserve the auditory ciliary structure but is critical to maintain sensory cilia function through binding and localisation of the ciliary proteins Iav and DmGucy2d.
- ADAM19 cleaves the PTH receptor and associates with brachydactyly type E
We studied a family with autosomal-dominant brachydactyly type E and found a mutated ADAM19; we show that ADAM19 cleaves PTHR1 and that aberrant PTHrP signaling could cause the phenotype.
- Ageing-dependent thiol oxidation reveals early oxidation of proteins with core proteostasis functions
Proteome-wide analysis of thiol oxidation during chronological ageing of yeast reveals evolutionarily conserved proteins as early-oxidation targets with a potential impact on proteostasis regulation.
- Oxidative phosphorylation is a pivotal therapeutic target of fibrodysplasia ossificans progressiva
Oxidative phosphorylation plays a pivotal role in heterotopic ossification associated with fibrodysplasia ossificans progressiva, underscoring its potential as a significant therapeutic target.
- Apical dehydration impairs the cystic fibrosis airway epithelium barrier via a β1-integrin/YAP1 pathway
Dehydration of the airway epithelial cell surface, a hallmark of CF, increases plasma membrane tension, resulting in altered Hippo signaling associated with the loss of barrier function.
- Oral bacteria induce IgA autoantibodies against a mesangial protein in IgA nephropathy model mice
This work shows that the CBX3, atypically expressed on the mesangial cell, is a target of IgA auto-Abs in IgA nephropathy model mice and patients. Such IgA auto-Abs are induced by oral bacteria in mice.