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Most read article(s)

  • Convergent evolution and horizontal gene transfer in Arctic Ocean microalgae
    Open Access
    Convergent evolution and horizontal gene transfer in Arctic Ocean microalgae

    Richard G Dorrell, Alan Kuo, Zoltan Füssy, Elisabeth H Richardson, Asaf Salamov, Nikola Zarevski, Nastasia J Freyria, Federico M Ibarbalz, Jerry Jenkins, Juan Jose Pierella Karlusich, Andrei Stecca Steindorff, Robyn E Edgar, Lori Handley, Kathleen Lail, Anna Lipzen, Vincent Lombard, John McFarlane, Charlotte Nef, Anna MG Novák Vanclová, Yi Peng, Chris Plott, Marianne Potvin, Fabio Rocha Jimenez Vieira, Kerrie Barry, Colomban de Vargas, Bernard Henrissat, Eric Pelletier, Jeremy Schmutz, Patrick Wincker, Joel B Dacks, Chris Bowler, Igor V Grigoriev, Connie Lovejoy

    Richard G Dorrell ... Connie Lovejoy

    Published 15 December 2022

    The Arctic Ocean stands apart from other oceans. Using multiple genomes and transcriptomes from cultured and environmental sources, we found distinct genetic modifications in Arctic microalgae consistent with biogeographically constrained trait selectivity as an adaptive force in algal evolution.

  • Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration
    Open Access
    Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration

    Flavia Roşianu, Simeon R Mihaylov, Noreen Eder, Antonie Martiniuc, Suzanne Claxton, Helen R Flynn, Shamsinar Jalal, Marie-Charlotte Domart, Lucy Collinson, Mark Skehel, Ambrosius P Snijders, Matthias Krause, Sharon A Tooze, Sila K Ultanir

    Flavia Roşianu ... Sila K Ultanir

    Published 29 November 2022

    NDR1/2 kinases are essential for efficient endocytosis and protein clearance by autophagy. Neuron-specific dual deletion of NDR1 and NDR2 causes cortical and hippocampal neurodegeneration, implicating these kinases in neuronal protein homeostasis and health.

  • Concordance of MERFISH spatial transcriptomics with bulk and single-cell RNA sequencing
    Open Access
    Concordance of MERFISH spatial transcriptomics with bulk and single-cell RNA sequencing

    Jonathan Liu, Vanessa Tran, Venkata Naga Pranathi Vemuri, Ashley Byrne, Michael Borja, Yang Joon Kim, Snigdha Agarwal, Ruofan Wang, Kyle Awayan, Abhishek Murti, Aris Taychameekiatchai, Bruce Wang, George Emanuel, Jiang He, John Haliburton, Angela Oliveira Pisco, Norma F Neff

    Jonathan Liu ... Norma F Neff

    Published 16 December 2022

    Single-cell RNA-seq is an important technology for capturing gene expression in individual cells. It has limitations as spatial context and accurate representation of cell types in the tissue are lost. Here, we show that MERFISH is comparable to scRNA-seq.

  • The mechanosensitive ion channel PIEZO1 promotes satellite cell function in muscle regeneration
    Open Access
    The mechanosensitive ion channel PIEZO1 promotes satellite cell function in muscle regeneration

    Kotaro Hirano, Masaki Tsuchiya, Akifumi Shiomi, Seiji Takabayashi, Miki Suzuki, Yudai Ishikawa, Yuya Kawano, Yutaka Takabayashi, Kaori Nishikawa, Kohjiro Nagao, Eiji Umemoto, Yasuo Kitajima, Yusuke Ono, Keiko Nonomura, Hirofumi Shintaku, Yasuo Mori, Masato Umeda, Yuji Hara

    Kotaro Hirano ... Yuji Hara

    Published 29 November 2022

    PIEZO1, a mechanosensitive ion channel, regulates Rho-GTPase activity and specifically accumulates at the midbody of muscle satellite cells to precisely control cell division for muscle regeneration.

  • <em>Drosophila</em> pVALIUM10 TRiP RNAi lines cause undesired silencing of Gateway-based transgenes
    Open Access
    Drosophila pVALIUM10 TRiP RNAi lines cause undesired silencing of Gateway-based transgenes

    Dimitrije Stanković, Gábor Csordás, Mirka Uhlirova

    Dimitrije Stanković ... Mirka Uhlirova

    Published 29 November 2022

    Drosophila pVALIUM10 TRiP RNAi lines cause undesirable knockdown of transgenic reporters and overexpression lines generated with the help of the Gateway cloning technology by targeting attB sites.

  • Disrupted in renal carcinoma 2 (DIRC2/SLC49A4) is an H<sup>+</sup>-driven lysosomal pyridoxine exporter
    Open Access
    Disrupted in renal carcinoma 2 (DIRC2/SLC49A4) is an H+-driven lysosomal pyridoxine exporter

    Shogo Akino, Tomoya Yasujima, Takahiro Yamashiro, Hiroaki Yuasa

    Shogo Akino ... Hiroaki Yuasa

    Published 1 December 2022

    DIRC2 is an H+-driven lysosomal pyridoxine exporter involved in the regulation of cellular pyridoxine storage.

  • DSCR1 deficiency ameliorates the Aβ pathology of Alzheimer’s disease by enhancing microglial activity
    Open Access
    DSCR1 deficiency ameliorates the Aβ pathology of Alzheimer’s disease by enhancing microglial activity

    Chiyeol Choi, Hyerin Kim, Jiyoung Oh, Chanho Park, Min Kim, Chu-Sook Kim, Jiyoung Park

    Chiyeol Choi ... Jiyoung Park

    Published 30 November 2022

    The authors suggested that an important role of Down syndrome critical region 1 (DSCR1) in microglial activation is to provide a potential therapeutic target for microglial Aβ clearance in Alzheimer’s disease.

  • Revisiting degron motifs in human AURKA required for its targeting by APC/C<sup>FZR1</sup>
    Open Access
    Revisiting degron motifs in human AURKA required for its targeting by APC/CFZR1

    Ahmed Abdelbaki, Camilla Ascanelli, Cynthia N Okoye, H Begum Akman, Giacomo Janson, Mingwei Min, Chiara Marcozzi, Anja Hagting, Rhys Grant, Maria De Luca, Italia Anna Asteriti, Giulia Guarguaglini, Alessandro Paiardini, Catherine Lindon

    Ahmed Abdelbaki ... Catherine Lindon

    Published 30 November 2022

    AURKA degron motifs are redefined to show that the so-called N-terminal “A-box” is in fact a D-box, and the so-called “D-box” in the C-terminus is not a degron but a motif critical for the active, degradable conformation of AURKA.

  • Transcriptome analyses in infertile men reveal germ cell–specific expression and splicing patterns
    Open Access
    Transcriptome analyses in infertile men reveal germ cell–specific expression and splicing patterns

    Lara M Siebert-Kuss, Henrike Krenz, Tobias Tekath, Marius Wöste, Sara Di Persio, Nicole Terwort, Margot J Wyrwoll, Jann-Frederik Cremers, Joachim Wistuba, Martin Dugas, Sabine Kliesch, Stefan Schlatt, Frank Tüttelmann, Jörg Gromoll, Nina Neuhaus, Sandra Laurentino

    Lara M Siebert-Kuss ... Sandra Laurentino

    Published 29 November 2022

    We uncover extensive germ cell type–dependent transcriptome changes in human spermatogenesis and demonstrate the potential of alternative splicing in the regulation of spermatogenesis.

  • Laminin is the ECM niche for trophoblast stem cells
    Open Access
    Laminin is the ECM niche for trophoblast stem cells

    Daiji Kiyozumi, Itsuko Nakano, Ryoko Sato-Nishiuchi, Satoshi Tanaka, Kiyotoshi Sekiguchi

    Daiji Kiyozumi ... Kiyotoshi Sekiguchi

    Published 14 January 2020

    Laminin functions as an ECM niche factor for trophoblast stem cells and secures trophoblast stem cell expansion through its interactions with integrin.

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