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β-Tubulin carboxy-terminal tails exhibit isotype-specific effects on microtubule dynamics in human gene-edited cellsThis study used human gene-edited cell models and image analysis to reveal that the tubulin C-terminal tails specifically regulate the dynamics of individual microtubules and coordinate microtubule behavior across the cell.
Regulation of microtubule dynamic instability by the carboxy-terminal tail of β-tubulinThis work examines how the carboxy-terminal tail domain of β-tubulin governs microtubule dynamic instability and the structure of plus ends using complementary in vivo and in vitro experiments.
BACE2 distribution in major brain cell types and identification of novel substratesβ-Site APP-cleaving enzyme 1 (BACE1) inhibition to treat Alzheimer’s disease also inhibits BACE2. This work shows BACE2 expression in the mouse brain and identifies its substrates. Increased BACE2 processing of vascular cell adhesion molecule 1 during inflammatory conditions cautions the use of current nonspecific BACE1 inhibitors in the clinic.
The ER morphology-regulating lunapark protein induces the formation of stacked bilayer discsLunapark, an ER protein implicated in stabilizing junctions of the tubular network and regulating morphology changes during mitosis, forms stacked bilayer discs upon reconstitution with phospholipids.
Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR/PR interactors driving toxicityProteomics and neuropathological validation show that aberrant poly-GR/PR proteins in C9orf72 ALS/FTD bind STAU2 and ribosomes and inhibit translation.
The expansion in lymphoid organs of IL-4+ BATF+ T follicular helper cells is linked to IgG4 class switching in vivoT follicular helper cells that secrete IL-4 accumulate in lymphoid organs in IgG4-related disease and are linked to IgG4 class switching.
Multiple membrane extrusion sites drive megakaryocyte migration into bone marrow blood vesselsMegakaryocytes enter bone marrow sinusoids to generate platelets by extrusion of internal membrane into the plasma membrane at fusion sites rather than microtubule-driven proplatelet extension.
CHRAC/ACF contribute to the repressive ground state of chromatinChromatin accessibility complex/ATP-utilizing chromatin assembly and remodeling factor help to establish basal transcriptional repression, conceivably through improving the regular spacing of nucleosomes in euchromatin.
Pervasive allele-specific regulation on RNA decay in hybrid miceUsing a F1 hybrid mouse system, this study globally investigates the effects of cis-regulatory divergence on RNA decay in mammals and reveals the evolutionary roles of RNA decay regulation.
Serine catabolism is essential to maintain mitochondrial respiration in mammalian cellsMitochondrial respiratory complex assembly requires the one-carbon unit generated from serine catabolism.