Most read article(s)
Tumor-intrinsic response to IFNγ shapes the tumor microenvironment and anti–PD-1 response in NSCLCUsing an immunocompetent mouse model of NSCLC, this study demonstrates that tumor-intrinsic response to IFNγ determines response to anti–PD-1 through alterations in the tumor microenvironment.
Dissection-independent production of Plasmodium sporozoites from whole mosquitoesOvercoming limitations of traditional dissection-dependent methods for malarial sporozoite isolation from mosquitoes, a new dissection-free method is presented that yields pure, infective sporozoites.
TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cellsThe spike protein S of SARS-CoV-2 is activated by TMPRSS2 and furin. Inhibition of either one of these proteases can render the S protein unable to mediate virus entry and, therefore, provides a promising approach for COVID-19 treatment.
Vaccinia virus hijacks ESCRT-mediated multivesicular body formation for virus egressPoxvirus extracellular virions are critical for virus virulence. This study shows that multivesicular bodies serve as a major cellular source of membrane for their formation and spread.
Edem1 activity in the fat body regulates insulin signalling and metabolic homeostasis in DrosophilaEdem1, an endoplasmic reticulum-resident protein, acts in the fat body to regulate insulin signalling and metabolic status in Drosophila, which aids in survival against nutrient deprivation.
Lipid-associated PML structures assemble nuclear lipid droplets containing CCTα and Lipin1PML proteins assemble into noncanonical lipid-associated PML structures (LAPS) on nuclear lipid droplets, which recruit CCTα and Lipin1 for the synthesis of phosphatidylcholine and triacylglycerol.
A multifaceted role of progranulin in regulating amyloid-beta dynamics and responsesProgranulin deficiency leads to decreased levels of human APP and Aβ in a sex- and age-dependent manner and enhanced inflammatory and lysosomal responses in the plaque-associated microglia.
Specific N-cadherin–dependent pathways drive human breast cancer dormancy in bone marrowCDH2 is required for connexin 43 (Cx43)–mediated gap junction intercellular communication between breast cancer cells and bone marrow niche cells to achieve dormancy and chemoresistance.
Pancreatic cancer is marked by complement-high blood monocytes and tumor-associated macrophagesThis study uses biomaterial scaffolds to identify a macrophage gene signature defined by high expression of C1qa, C1qb, and Trem2 that is elevated systemically in mouse and human pancreatic cancer.
DNA damage in embryonic neural stem cell determines FTLDs’ fate via early-stage neuronal necrosisDNA damage due to impairment of DNA damage repair functions in NSCs is carried over to neurons and triggers early-stage YAP-dependent neuronal necrosis (TRIAD) amplifying a chain of necrosis in FTLDs.