Most read article(s)
Mitochondrial phosphoproteomes are functionally specialized across tissuesThis study explores tissue-specific mitochondrial proteomes and phosphoproteomes in unprecedented depth, offering valuable insights into mitochondrial organization and specialization.
Enhancer-driven 3D chromatin domain folding modulates transcription in human mammary tumor cellsThe study shows that estrogen activates transcription within pre-established chromosomal 3D architectures, strengthening enhancer interactions through local accumulation of the estrogen receptor α.
Interconnections between m6A RNA modification, RNA structure, and protein–RNA complex assemblyThis review summarizes current knowledge and future directions on the mechanisms that govern the interplay between m6A RNA modification, RNA folding, and protein–RNA interactions, focusing on the mechanisms and available quantitative information.
Fibro-adipogenic progenitors of dystrophic mice are insensitive to NOTCH regulation of adipogenesisThe NOTCH pathway, in concert with TNFa, restrains adipogenesis of muscle fibro-adipogenic progenitors (FAPs). Dystrophin-deficient FAPs are less sensitive to NOTCH anti-adipogenic signals, thus explaining why fat infiltrations are solely observed in the muscles of dystrophic individuals.
Cristae dynamics is modulated in bioenergetically compromised mitochondriaLive-cell super-resolution nanoscopy reveals modulation of cristae dynamics in bioenergetically compromised mitochondria demonstrating that cristae morphology and dynamics are intricately connected.
ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasisA protein complex composed of the outer mitochondrial membrane protein SYNJ2BP and the endoplasmic reticulum protein ESYT1 tethers the two organelles to facilitate calcium and lipid transfer.
Intrinsic deletion at 10q23.31, including the PTEN gene locus, is aggravated upon CRISPR-Cas9–mediated genome engineering in HAP1 cells mimicking cancer profilesThe unintended 10q23.31 deletion frequency rises in HAP1 cells stressed during CRISPR-Cas9 engineering, leading to aberrant molecular and cellular changes resembling common cancer patient deletions.
KCNQ potassium channels modulate Wnt activity in gastro-oesophageal adenocarcinomasKCNQ3, a potassium channel, is frequently genetically altered in gastro-oesophageal adenocarcinomas and found to be significantly associated with WNT and MYC activity, and cellular proliferation.
Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activityExpression of the Vnn1 pantetheinase by sarcomas is tumor suppressive by limiting the use of aerobic glycolysis for growth and rescuing mitochondrial activity through CoA regeneration.
TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cellsThe spike protein S of SARS-CoV-2 is activated by TMPRSS2 and furin. Inhibition of either one of these proteases can render the S protein unable to mediate virus entry and, therefore, provides a promising approach for COVID-19 treatment.