Most read article(s)
Kinesin-8B controls basal body function and flagellum formation and is key to malaria transmissionThis comprehensive study describes the key role and real-time dynamics of Plasmodium kinesin-8B in microtubule-based basal body and axoneme assembly during flagellum (male gamete) formation and parasite transmission.
Cholesterol ensures ciliary polycystin-2 localization to prevent polycystic kidney diseasePeroxisome-mediated cholesterol trafficking is essential for the ciliary localization of the polycystin complex to prevent the occurrence of polycystic kidney.
Screening of homing and tissue-penetrating peptides by microdialysis and in vivo phage displayIn vivo phage display combined with microdialysis can be used for the discovery of vascular homing peptides capable of extravasation and tissue penetration in the target organ.
Visualisation of Euglena gracilis organelles and cytoskeleton using expansion microscopyWe applied expansion microscopy to visualise the cytoskeleton, mitochondria, and chloroplasts of Euglena gracilis, which enabled high-resolution imaging, revealing cellular structures and organelle development, demonstrating expansion microscopy’s utility as a complementary method to electron microscopy for studying this protist.
- 2024 reviewer index
The LSA Editors thank these scientists for sharing their time and expertise while reviewing manuscripts in 2024. We sincerely appreciate their support.
Impaired primitive erythropoiesis and defective vascular development in Trim71-KO embryosWe report that Trim71-KO leads to decreased embryonic primitive erythropoiesis and impaired vascular development, and provide evidence for direct repression of Eomes via Trim71-mediated mRNA binding.
PICH impacts the spindle assembly checkpoint via its DNA translocase and SUMO-interaction activitiesGenome-edited cell lines for PICH depletion or replacement to loss of function mutants revealed an unidentified PICH function impacting SAC activity through modulating Bub1 association at kinetochores.
A biallelic variant in GORASP1 causes a novel Golgipathy with glycosylation and mitotic defectsThis study identifies the first human pathogenic variant in GORASP1, the gene encoding the Golgi stacking protein GRASP65, and demonstrates its consequences on glycosylation and mitotic progression.
Endolysosome-targeted nanoparticle delivery of antiviral therapy for coronavirus infectionsLysosome-targeting nanoparticles, loaded with mefloquine, inhibit coronavirus infection in mouse MHV-A59 and human OC43 coronavirus model systems, as well as SARS-CoV-2 WA1 and its Omicron variant in a human lung epithelium model.
Identification of TNFAIP2 as a unique cellular regulator of CSF-1 receptor activationThis study demonstrates the molecular mechanism and biological significance of the formation of large CSF-1 receptor aggregates in macrophages.