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Most read article(s)

  • New botulinum neurotoxin constructs for treatment of chronic pain
    Open Access
    New botulinum neurotoxin constructs for treatment of chronic pain

    Charlotte Leese, Claire Christmas, Judit Mészáros, Stephanie Ward, Maria Maiaru, Stephen P Hunt, Bazbek Davletov

    Charlotte Leese ... Bazbek Davletov

    Published 11 April 2023

    A new technique to make therapeutic botulinum neurotoxins via isopeptide bonding is described. The novel elongated botulinum neurotoxin can treat nerve injury pain without causing muscle paralysis.

  • RAS and PP2A activities converge on epigenetic gene regulation
    Open Access
    RAS and PP2A activities converge on epigenetic gene regulation

    Anna Aakula, Mukund Sharma, Francesco Tabaro, Reetta Nätkin, Jesse Kamila, Henrik Honkanen, Matthieu Schapira, Cheryl Arrowsmith, Matti Nykter, Jukka Westermarck

    Anna Aakula ... Jukka Westermarck

    Published 1 March 2023

    This study reveals a hidden regulatory layer in epigenetic gene expression in cancer by co-operative phosphoregulation by RAS and tumor suppressor phosphatase PP2A.

  • Bats experience age-related hearing loss (presbycusis)
    Open Access
    Bats experience age-related hearing loss (presbycusis)

    Yifat Chaya Tarnovsky, Shahar Taiber, Yomiran Nissan, Arjan Boonman, Yaniv Assaf, Gerald S Wilkinson, Karen B Avraham, Yossi Yovel

    Yifat Chaya Tarnovsky ... Yossi Yovel

    Published 30 March 2023

    Bats exhibited age-related hearing loss. Bats are exposed to immense conspecific noise, but the frequency-dependent hearing loss was not correlated to the noise.

  • The pro-inflammatory response to influenza A virus infection is fueled by endothelial cells
    Open Access
    The pro-inflammatory response to influenza A virus infection is fueled by endothelial cells

    Lisa Bauer, Laurine C Rijsbergen, Lonneke Leijten, Feline FW Benavides, Danny Noack, Mart M Lamers, Bart L Haagmans, Rory D de Vries, Rik L de Swart, Debby van Riel

    Lisa Bauer ... Debby van Riel

    Published 18 April 2023

    A co-culture model of human primary endothelial cells and organoid-derived epithelial cells shows that endothelial cells are abortively infected by influenza A virus but can drive the pro-inflammatory response.

  • On the relation of gene essentiality to intron structure: a computational and deep learning approach
    Open Access
    On the relation of gene essentiality to intron structure: a computational and deep learning approach

    Ethan Schonfeld, Edward Vendrow, Joshua Vendrow, Elan Schonfeld

    Ethan Schonfeld ... Elan Schonfeld

    Published 27 April 2021

    A deep learning classifier predicts gene essentiality by intron sequence. A unique set of intron features of essential genes was found and its importance demonstrated by a high-performing classifier.

  • Sleep–wake patterns are altered with age, Prdm13 signaling in the DMH, and diet restriction in mice
    Open Access
    Sleep–wake patterns are altered with age, Prdm13 signaling in the DMH, and diet restriction in mice

    Shogo Tsuji, Cynthia S Brace, Ruiqing Yao, Yoshitaka Tanie, Hirobumi Tada, Nicholas Rensing, Seiya Mizuno, Julio Almunia, Yingyi Kong, Kazuhiro Nakamura, Takahisa Furukawa, Noboru Ogiso, Shinya Toyokuni, Satoru Takahashi, Michael Wong, Shin-ichiro Imai, Akiko Satoh

    Shogo Tsuji ... Akiko Satoh

    Published 12 April 2023

    This study found that age-associated sleep changes are ameliorated by DR in the presence of Prdm13 signaling in the DMH, suggesting Prdm13+ DMH neurons will be of great interest to explore a potential intervention on age-associated sleep changes.

  • The role of the mitochondrial outer membrane protein SLC25A46 in mitochondrial fission and fusion
    Open Access
    The role of the mitochondrial outer membrane protein SLC25A46 in mitochondrial fission and fusion

    Jana Schuettpelz, Alexandre Janer, Hana Antonicka, Eric A Shoubridge

    Jana Schuettpelz ... Eric A Shoubridge

    Published 28 March 2023

    The mitochondrial outer membrane protein SLC25A46 localizes to mitochondrial fusion and fission sites, and loss of function alters mitochondrial morphology and oligomerization states of MFN2 and OPA1.

  • An unconventional cancer-promoting function of methamphetamine in hepatocellular carcinoma
    Open Access
    An unconventional cancer-promoting function of methamphetamine in hepatocellular carcinoma

    Zizhen Si, GuanJun Yang, Xidi Wang, Zhaoying Yu, Qian Pang, Shuangshuang Zhang, Liyin Qian, Yuer Ruan, Jing Huang, Liu Yu

    Zizhen Si ... Liu Yu

    Published 20 January 2023

    METH use is associated with a higher incidence of hepatocellular carcinoma (HCC) in METH abusers and rehabilitees. METH exposure promotes HCC progression by ROS-mediated activation of the Ras/MEK/ERK signaling pathway. Clearance of ROS by NAC abolishes METH-induced HCC progression.

  • An OMA1 redox site controls mitochondrial homeostasis, sarcoma growth, and immunogenicity
    Open Access
    An OMA1 redox site controls mitochondrial homeostasis, sarcoma growth, and immunogenicity

    Richard Miallot, Virginie Millet, Yann Groult, Angelika Modelska, Lydie Crescence, Sandrine Roulland, Sandrine Henri, Bernard Malissen, Nicolas Brouilly, Laurence Panicot-Dubois, Renaud Vincentelli, Gerlind Sulzenbacher, Pascal Finetti, Aurélie Dutour, Jean-Yves Blay, François Bertucci, Franck Galland, Philippe Naquet

    Richard Miallot ... Philippe Naquet

    Published 5 April 2023

    This work describes how a mutation affecting mitochondrial metabolism in a sarcoma model induces protective immunity against the tumor and how this result might be relevant for sarcoma patients.

  • Retinitis pigmentosa–associated mutations in mouse Prpf8 cause misexpression of circRNAs and degeneration of cerebellar granule cells
    Open Access
    Retinitis pigmentosa–associated mutations in mouse Prpf8 cause misexpression of circRNAs and degeneration of cerebellar granule cells

    Michaela Krausová, Michaela Kreplová, Poulami Banik, Zuzana Cvačková, Jan Kubovčiak, Martin Modrák, Dagmar Zudová, Jiří Lindovský, Agnieszka Kubik-Zahorodna, Marcela Pálková, Michal Kolář, Jan Procházka, Radislav Sedláček, David Staněk

    Michaela Krausová ... David Staněk

    Published 5 April 2023

    This study shows that Prpf8 mutations associated with human retinal degeneration in mice alter circRNA expression in cerebellar granule cells and induce their apoptosis.

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