Most read article(s)
Tumor-intrinsic response to IFNγ shapes the tumor microenvironment and anti–PD-1 response in NSCLCUsing an immunocompetent mouse model of NSCLC, this study demonstrates that tumor-intrinsic response to IFNγ determines response to anti–PD-1 through alterations in the tumor microenvironment.
Fungal mycelia and bacterial thiamine establish a mutualistic growth mechanismBacterial cells travel along fungal highway and pay thiamine as a toll to the fungus. Simultaneous spatial and metabolic interactions in communicating bacterial and fungal species establish a mutualism that facilitates them to obtain an environmental niche and nutrient.
TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cellsThe spike protein S of SARS-CoV-2 is activated by TMPRSS2 and furin. Inhibition of either one of these proteases can render the S protein unable to mediate virus entry and, therefore, provides a promising approach for COVID-19 treatment.
In vivo CRISPR/Cas9 knockout screen: TCEAL1 silencing enhances docetaxel efficacy in prostate cancerA whole genome in vivo CRISPR/Cas9 screen identifies TCEAL1 as a potential target to sensitise prostate cancer cells to docetaxel to improve the efficacy of chemotherapy.
Gene selection for optimal prediction of cell position in tissues from single-cell transcriptomics dataWe describe and provide an array of diverse methods to predict cellular positions in tissue from RNA-seq data selecting mapping genes according to their spatial/statistical properties and their effect on improving the cell positioning.
Neurturin regulates the lung-resident macrophage inflammatory response to viral infectionThe neurotrophic factor RET is induced in lung macrophages by viral triggers and activation via its ligand neurturin regulates matrix proteins and cytokines that shape the inflammatory response.
Chromosome instability induced by a single defined sister chromatid fusionNewly developed Fusion Visualization (FuVis) system reveals a single Xp sister chromatid fusion induces micronuclei formation, acentric chromosome fragments, and cell cycle instabilities.
Role of opioid signaling in kidney damage during the development of salt-induced hypertensionStimulation of kappa opioid receptors modulates calcium influx via TRPC6 channels in podocytes, which ultimately compromises the integrity of the glomerular filtration barrier and promotes a marked worsening of blood pressure control and renal damage.
USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylationA new inhibitor of the deubiquitylase USP30, an actionable target relevant to Parkinson’s Disease, is introduced and characterised for parameters related to mitophagy.
Brain is an endocrine organ through secretion and nuclear transfer of parathymosinThe hypothalamus and brain neurons orchestrate the secretion and nuclear transfer of PTMS which is neuroprotective against aging-related disorders.