Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Methods & Resources
    • Archive
    • Subjects
  • Collections
  • Submit
    • Submit a Manuscript
    • Author Guidelines
    • License, Copyright, Fee
    • FAQ
    • Why Submit
  • About
    • About Us
    • Editors & Staff
    • Board Members
    • Licensing and Reuse
    • Reviewer Guidelines
    • Privacy Policy
    • Advertise
    • Contact Us
    • LSA LLC
  • Alerts
  • Other Publications
    • EMBO Press
    • The EMBO Journal
    • EMBO reports
    • EMBO Molecular Medicine
    • Molecular Systems Biology
    • Rockefeller University Press
    • Journal of Cell Biology
    • Journal of Experimental Medicine
    • Journal of General Physiology
    • Cold Spring Harbor Laboratory Press
    • Genes & Development
    • Genome Research

User menu

  • My alerts

Search

  • Advanced search
Life Science Alliance
  • Other Publications
    • EMBO Press
    • The EMBO Journal
    • EMBO reports
    • EMBO Molecular Medicine
    • Molecular Systems Biology
    • Rockefeller University Press
    • Journal of Cell Biology
    • Journal of Experimental Medicine
    • Journal of General Physiology
    • Cold Spring Harbor Laboratory Press
    • Genes & Development
    • Genome Research
  • My alerts
Life Science Alliance

Advanced Search

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Methods & Resources
    • Archive
    • Subjects
  • Collections
  • Submit
    • Submit a Manuscript
    • Author Guidelines
    • License, Copyright, Fee
    • FAQ
    • Why Submit
  • About
    • About Us
    • Editors & Staff
    • Board Members
    • Licensing and Reuse
    • Reviewer Guidelines
    • Privacy Policy
    • Advertise
    • Contact Us
    • LSA LLC
  • Alerts
  • Follow lsa Template on Twitter

Most read article(s)

  • ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathway
    Open Access
    ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathway

    Marta Wróbel, Jarosław Cendrowski, Ewelina Szymańska, Malwina Grębowicz-Maciukiewicz, Noga Budick-Harmelin, Matylda Macias, Aleksandra Szybińska, Michał Mazur, Krzysztof Kolmus, Krzysztof Goryca, Michalina Dąbrowska, Agnieszka Paziewska, Michał Mikula, Marta Miączyńska

    Marta Wróbel ... Marta Miączyńska

    Published 30 March 2022

    ESCRT-I deficiency impairs lysosome membrane turnover and induces homeostatic responses to lysosomal nutrient starvation including activation of MiT-TFE signaling caused by inhibition of the substrate-specific mTORC1 pathway.

  • Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids
    Open Access
    Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids

    Maarten H Geurts, Eyleen de Poel, Cayetano Pleguezuelos-Manzano, Rurika Oka, Léo Carrillo, Amanda Andersson-Rolf, Matteo Boretto, Jesse E Brunsveld, Ruben van Boxtel, Jeffrey M Beekman, Hans Clevers

    Maarten H Geurts ... Hans Clevers

    Published 9 August 2021

    Here, the authors evaluate prime editing in human adult stem cell–derived organoids. TP53 mutations are modeled in hepatocyte and colon organoids and the clinical application of prime editing is evaluated by repairing mutations in CFTR without genome-wide off-targets.

  • Intensive single-cell analysis reveals immune-cell diversity among healthy individuals
    Open Access
    Intensive single-cell analysis reveals immune-cell diversity among healthy individuals

    Yukie Kashima, Keiya Kaneko, Patrick Reteng, Nina Yoshitake, Lucky Ronald Runtuwene, Satoi Nagasawa, Masaya Onishi, Masahide Seki, Ayako Suzuki, Sumio Sugano, Mamiko Sakata-Yanagimoto, Yumiko Imai, Kaori Nakayama-Hosoya, Ai Kawana-Tachikawa, Taketoshi Mizutani, Yutaka Suzuki

    Yukie Kashima ... Yutaka Suzuki

    Published 5 April 2022

    This study describes the diversity of the immune-cell profiling in healthy adults at the single-cell level using RNA-seq, VDJ repertoires, and proteome.

  • SMN-deficient cells exhibit increased ribosomal DNA damage
    Open Access
    SMN-deficient cells exhibit increased ribosomal DNA damage

    Evangelia Karyka, Nelly Berrueta Ramirez, Christopher P Webster, Paolo M Marchi, Emily J Graves, Vinay K Godena, Lara Marrone, Anushka Bhargava, Swagat Ray, Ke Ning, Hannah Crane, Guillaume M Hautbergue, Sherif F El-Khamisy, Mimoun Azzouz

    Evangelia Karyka ... Mimoun Azzouz

    Published 19 April 2022

    SMN deficiency leads to elevated ribosomal DNA damage that results in impaired ribosomal RNA synthesis and translation and is accompanied by a motor neuron-specific down-regulation of DDX21 protein.

  • Laminin is the ECM niche for trophoblast stem cells
    Open Access
    Laminin is the ECM niche for trophoblast stem cells

    Daiji Kiyozumi, Itsuko Nakano, Ryoko Sato-Nishiuchi, Satoshi Tanaka, Kiyotoshi Sekiguchi

    Daiji Kiyozumi ... Kiyotoshi Sekiguchi

    Published 14 January 2020

    Laminin functions as an ECM niche factor for trophoblast stem cells and secures trophoblast stem cell expansion through its interactions with integrin.

  • Phospholipids alter activity and stability of mitochondrial membrane-bound ubiquitin ligase MARCH5
    Open Access
    Phospholipids alter activity and stability of mitochondrial membrane-bound ubiquitin ligase MARCH5

    Lisa Merklinger, Johannes Bauer, Per A Pedersen, Rune Busk Damgaard, J Preben Morth

    Lisa Merklinger ... J Preben Morth

    Published 22 April 2022

    This study shows that lipids can act as regulators for the ubiquitination process and can control the stability and activity of a membrane-embedded E3 ubiquitin ligase.

  • TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells
    Open Access
    TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells

    Dorothea Bestle, Miriam Ruth Heindl, Hannah Limburg, Thuy Van Lam van, Oliver Pilgram, Hong Moulton, David A Stein, Kornelia Hardes, Markus Eickmann, Olga Dolnik, Cornelius Rohde, Hans-Dieter Klenk, Wolfgang Garten, Torsten Steinmetzer, Eva Böttcher-Friebertshäuser

    Dorothea Bestle ... Eva Böttcher-Friebertshäuser

    Published 23 July 2020

    The spike protein S of SARS-CoV-2 is activated by TMPRSS2 and furin. Inhibition of either one of these proteases can render the S protein unable to mediate virus entry and, therefore, provides a promising approach for COVID-19 treatment.

  • Quantitative analysis of nuclear pore complex organization in <em>Schizosaccharomyces pombe</em>
    Open Access
    Quantitative analysis of nuclear pore complex organization in Schizosaccharomyces pombe

    Joseph M Varberg, Jay R Unruh, Andrew J Bestul, Azqa A Khan, Sue L Jaspersen

    Joseph M Varberg ... Sue L Jaspersen

    Published 30 March 2022

    Characterization of nuclear pores in Schizosaccharomyces pombe identifies regions of heterogeneous NPC density and composition and shows that NPCs are excluded near the spindle pole body by Lem2-mediated centromere tethering.

  • Profiles of telomeric repeats in Insecta reveal diverse forms of telomeric motifs in Hymenopterans
    Open Access
    Profiles of telomeric repeats in Insecta reveal diverse forms of telomeric motifs in Hymenopterans

    Yihang Zhou, Yi Wang, Xiao Xiong, Arthur G Appel, Chao Zhang, Xu Wang

    Yihang Zhou ... Xu Wang

    Published 1 April 2022

    A bioinformatic pipeline for telomeric repeat motif detection was applied to 129 insect species and identified diverse forms of telomeric motifs in Hymenopterans, including canonical 5-bp, novel 8- and 9-bp forms, suggesting extraordinary evolutionary fluidity of telomeric repeat in Hymenopterans.

  • mRNA COVID-19 vaccine booster fosters B- and T-cell responses in immunocompromised patients
    Open Access
    mRNA COVID-19 vaccine booster fosters B- and T-cell responses in immunocompromised patients

    Elena Azzolini, Chiara Pozzi, Luca Germagnoli, Bianca Oresta, Nicola Carriglio, Mariella Calleri, Carlo Selmi, Maria De Santis, Silvia Finazzi, Carmelo Carlo-Stella, Alexia Bertuzzi, Francesca Motta, Angela Ceribelli, Alberto Mantovani, Fabrizio Bonelli, Maria Rescigno

    Elena Azzolini ... Maria Rescigno

    Published 15 February 2022

    Immunocompromised patients poorly respond to two doses of SARS-CoV-2 mRNA vaccines. However, an additional booster dose elicits a strong humoral and cellular immune response in these subjects.

Pages

  • Next
  • 1
  • 2
  • 3
  • 4
  • 5

EMBO Press LogoRockefeller University Press LogoCold Spring Harbor Logo

Content

  • Home
  • Newest Articles
  • Current Issue
  • Archive
  • Subject Collections

For Authors

  • Submit a Manuscript
  • Author Guidelines
  • License, copyright, Fee

Other Services

  • Alerts
  • Twitter
  • RSS Feeds

More Information

  • Editors & Staff
  • Reviewer Guidelines
  • Feedback
  • Licensing and Reuse
  • Privacy Policy

ISSN: 2575-1077
© 2022 Life Science Alliance LLC

Life Science Alliance is registered as a trademark in the U.S. Patent and Trade Mark Office and in the European Union Intellectual Property Office.