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Most read article(s)

  • Genetic and stochastic influences upon tumor formation and tumor types in Li-Fraumeni mouse models
    Open Access
    Genetic and stochastic influences upon tumor formation and tumor types in Li-Fraumeni mouse models

    Chang S Chan, Yvonne Sun, Hua Ke, Yuhan Zhao, Merzu Belete, Cen Zhang, Zhaohui Feng, Arnold J Levine, Wenwei Hu

    Chang S Chan ... Wenwei Hu

    Published 29 December 2020

    This study used mice heterozygous for Tp53 mutations with different genetic backgrounds to investigate the genetic or stochastic factors that modify the penetrance of tumor formation by Tp53 mutation.

  • An atlas of human proximal epididymis reveals cell-specific functions and distinct roles for CFTR
    Open Access
    An atlas of human proximal epididymis reveals cell-specific functions and distinct roles for CFTR

    Shih-Hsing Leir, Shiyi Yin, Jenny L Kerschner, Wilmel Cosme, Ann Harris

    Shih-Hsing Leir ... Ann Harris

    Published 27 August 2020

    A coordinated process of maturation in the lumen of the epididymis is required for sperm to fertilize an egg. A single cell atlas of the human proximal epididymis reveals key cell-specific functions, regional specialization, and two roles for CFTR.

  • Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4
    Open Access
    Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4

    Andreia Mendes, Julien P Gigan, Christian Rodriguez Rodrigues, Sébastien A Choteau, Doriane Sanseau, Daniela Barros, Catarina Almeida, Voahirana Camosseto, Lionel Chasson, Adrienne W Paton, James C Paton, Rafael J Argüello, Ana-Maria Lennon-Duménil, Evelina Gatti, Philippe Pierre

    Andreia Mendes ... Philippe Pierre

    Published 21 December 2020

    Differentiated dendritic cells display an unusual activation of the integrated stress response, which is necessary for normal type-I Interferon production and cell migration.

  • Predicting gene regulatory networks from cell atlases
    Open Access
    Predicting gene regulatory networks from cell atlases

    Andreas Fønss Møller, Kedar Nath Natarajan

    Andreas Fønss Møller ... Kedar Nath Natarajan

    Published 21 September 2020

    Integrated single-cell gene regulatory network from three mouse cell atlases captures global and cell type–specific regulatory modules and crosstalk, important for cellular identity.

  • IMiDs induce FAM83F degradation via an interaction with CK1α to attenuate Wnt signalling
    Open Access
    IMiDs induce FAM83F degradation via an interaction with CK1α to attenuate Wnt signalling

    Karen Dunbar, Thomas J Macartney, Gopal P Sapkota

    Karen Dunbar ... Gopal P Sapkota

    Published 23 December 2020

    IMiDs induce the degradation of the FAM83F–CK1α complex but no other FAM83–CK1α complexes, resulting in attenuation of Wnt signalling.

  • FAM83F regulates canonical Wnt signalling through an interaction with CK1α
    Open Access
    FAM83F regulates canonical Wnt signalling through an interaction with CK1α

    Karen Dunbar, Rebecca A Jones, Kevin Dingwell, Thomas J Macartney, James C Smith, Gopal P Sapkota

    Karen Dunbar ... Gopal P Sapkota

    Published 24 December 2020

    FAM83F directs CK1α to the plasma membrane, and through its association with CK1α, FAM83F mediates canonical Wnt signalling.

  • Sustained <em>Helicobacter pylori</em> infection accelerates gastric dysplasia in a mouse model
    Open Access
    Sustained Helicobacter pylori infection accelerates gastric dysplasia in a mouse model

    Valerie P O’Brien, Amanda L Koehne, Julien Dubrulle, Armando E Rodriguez, Christina K Leverich, V Paul Kong, Jean S Campbell, Robert H Pierce, James R Goldenring, Eunyoung Choi, Nina R Salama

    Valerie P O’Brien ... Nina R Salama

    Published 11 December 2020

    Hp infection was found to alter metaplasia and accelerate dysplasia in mice. Thus, Hp can promote gastric preneoplastic progression, in addition to its known role in initiating chronic inflammation.

  • Human G-MDSCs are neutrophils at distinct maturation stages promoting tumor growth in breast cancer
    Open Access
    Human G-MDSCs are neutrophils at distinct maturation stages promoting tumor growth in breast cancer

    Meliha Mehmeti-Ajradini, Caroline Bergenfelz, Anna-Maria Larsson, Robert Carlsson, Kristian Riesbeck, Jonas Ahl, Helena Janols, Marlene Wullt, Anders Bredberg, Eva Källberg, Frida Björk Gunnarsdottir, Camilla Rydberg Millrud, Lisa Rydén, Gesine Paul, Niklas Loman, Jörgen Adolfsson, Ana Carneiro, Karin Jirström, Fredrika Killander, Daniel Bexell, Karin Leandersson

    Meliha Mehmeti-Ajradini ... Karin Leandersson

    Published 21 September 2020

    This study shows that immunosuppressive primary breast cancer patient–derived G-MDSCs (PMN-MDSCs) are neutrophils at a range of maturations stages, and provides in vivo evidence for that human G-MDSCs also promote tumor growth and myeloid immune cell exclusion.

  • USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation
    Open Access
    USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation

    Emma V Rusilowicz-Jones, Jane Jardine, Andreas Kallinos, Adan Pinto-Fernandez, Franziska Guenther, Mariacarmela Giurrandino, Francesco G Barone, Katy McCarron, Christopher J Burke, Alejandro Murad, Aitor Martinez, Elena Marcassa, Malte Gersch, Alexandre J Buckmelter, Katherine J Kayser-Bricker, Frederic Lamoliatte, Akshada Gajbhiye, Simon Davis, Hannah C Scott, Emma Murphy, Katherine England, Heather Mortiboys, David Komander, Matthias Trost, Benedikt M Kessler, Stephanos Ioannidis, Michael K Ahlijanian, Sylvie Urbé, Michael J Clague

    Emma V Rusilowicz-Jones ... Michael J Clague

    Published 7 July 2020

    A new inhibitor of the deubiquitylase USP30, an actionable target relevant to Parkinson’s Disease, is introduced and characterised for parameters related to mitophagy.

  • Polycomb mutant partially suppresses DNA hypomethylation–associated phenotypes in Arabidopsis
    Open Access
    Polycomb mutant partially suppresses DNA hypomethylation–associated phenotypes in Arabidopsis

    Martin Rougée, Leandro Quadrana, Jérôme Zervudacki, Valentin Hure, Vincent Colot, Lionel Navarro, Angélique Deleris

    Martin Rougée ... Angélique Deleris

    Published 21 December 2020

    A mutation in Arabidopsis polycomb repressive complex 2 partially suppresses the transposon activity observed in a DNA methylation mutant, challenging expectations.

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