Aging
Divergent roles of RIPK3 and MLKL in high-fat diet–induced obesity and MAFLD in miceThis study shows how necroptotic effector MLKL can induce obesity and perturb lipid metabolism to drive MAFLD progression, independent of RIPK3 that regulates inflammatory events.
Cellular stress and epigenetic regulation in adult stem cellsStem cells’ response to various stresses and the epigenetic scarring that remains after the stress has been mitigated is highly relevant to stem cell function.
Morphological correlates of synaptic protein turnover in the mouse brainSynapse size, vesicle numbers, or the presence of a nascent zone, are indicators for the metabolic age of the synapse, in both young adult and old mice.
STAT3 inhibition recovers regeneration of aged muscles by restoring autophagy in muscle stem cellsThis study shows that STAT3 regulates MuSC function by both transcription-dependent and transcription-independent control of autophagy. STAT3 inhibition reverses age-dependent impairment of muscle regeneration, by restoring autophagy in aged MuSCs.
Ageing-dependent thiol oxidation reveals early oxidation of proteins with core proteostasis functionsProteome-wide analysis of thiol oxidation during chronological ageing of yeast reveals evolutionarily conserved proteins as early-oxidation targets with a potential impact on proteostasis regulation.
Targeting circulating labile heme as a defense strategy against malariaMalaria remains a major cause of human morbidity and mortality. Circulating labile heme is an independent risk factor for severe P. falciparum malaria, suggesting that labile heme may be a therapeutic target against severe malaria.
Apolipoprotein E intersects with amyloid-β within neuronsApolipoprotein E4, the most important genetic risk factor for Alzheimer's disease, is shown to internalize into neurons and intersect with amyloid-β in endosomes–autophagosomes of neurites and modulate intraneuronal amyloid-β-42.
Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brainPleiotropic consequences of deletion of SERF in mice reveals biological functions in cell growth and development and supports the existence of biological modifiers of amyloid polymorphisms in the brain.
Sleep–wake patterns are altered with age, Prdm13 signaling in the DMH, and diet restriction in miceThis study found that age-associated sleep changes are ameliorated by DR in the presence of Prdm13 signaling in the DMH, suggesting Prdm13+ DMH neurons will be of great interest to explore a potential intervention on age-associated sleep changes.
MicroRNAs in tear fluids predict underlying molecular changes associated with Alzheimer’s diseaseThis study demonstrated the translational potential of deregulated tear fluid miRNAs associated with amyloid beta production and proinflammation in a transgenic AD mouse model.