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Aging

  • Reduced adhesion of aged intestinal stem cells contributes to an accelerated clonal drift
    Open Access
    Reduced adhesion of aged intestinal stem cells contributes to an accelerated clonal drift

    Ali Hageb, Torsten Thalheim, Kalpana J Nattamai, Bettina Möhrle, Mehmet Saçma, Vadim Sakk, Lars Thielecke, Kerstin Cornils, Carolin Grandy, Fabian Port, Kay-E Gottschalk, Jan-Philipp Mallm, Ingmar Glauche, Jörg Galle, Medhanie A Mulaw, Hartmut Geiger

    Ali Hageb ... Hartmut Geiger

    Published 29 April 2022

    Analysis of clonal dynamics of intestinal stem cells supports an accelerated clonal drift upon aging, likely because of reduced adhesion of aged ISCs because of reduced canonical Wnt signaling.

  • Loss of SET1/COMPASS methyltransferase activity reduces lifespan and fertility in <em>Caenorhabditis elegans</em>
    Open Access
    Loss of SET1/COMPASS methyltransferase activity reduces lifespan and fertility in Caenorhabditis elegans

    Matthieu Caron, Loïc Gely, Steven Garvis, Annie Adrait, Yohann Couté, Francesca Palladino, Paola Fabrizio

    Matthieu Caron ... Paola Fabrizio

    Published 10 December 2021

    Contrary to prior reports, this study shows that a loss of COMPASS components or SET1 activity reduces Caenorhabditis elegans lifespan, suggesting that as in yeast, H3K4 methylation is essential for normal longevity.

  • β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy
    Open Access
    β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy

    Jung-AA Woo, Yan Yan, Teresa R Kee, Sara Cazzaro, Kyle C McGill Percy, Xinming Wang, Tian Liu, Stephen B Liggett, David E Kang

    Jung-AA Woo ... David E Kang

    Published 3 December 2021

    GPCRs regulator, β-arrestin1, is increased in FTLD-tau patients, is required for β2-adrenergic receptor and metabotropic glutamate receptor 2-induced tau phosphorylation, promotes tau aggregation by impairing autophagy, and destabilizes microtubule dynamics, whereas genetic reduction in β-arrestin1 mitigates tauopathy and cognitive impairments.

  • Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors
    Open Access
    Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors

    Sonja K Soo, Annika Traa, Paige D Rudich, Meeta Mistry, Jeremy M Van Raamsdonk

    Sonja K Soo ... Jeremy M Van Raamsdonk

    Published 28 September 2021

    This work highlights the importance of the mitochondrial unfolded protein response in allowing organisms to survive external stressors through up-regulation of other stress response pathways.

  • TPC2 promotes choroidal angiogenesis and inflammation in a mouse model of neovascular age-related macular degeneration
    Open Access
    TPC2 promotes choroidal angiogenesis and inflammation in a mouse model of neovascular age-related macular degeneration

    Yanfen Li, Christian Schön, Cheng-Chang Chen, Zhuo Yang, Raffael Liegl, Elisa Murenu, Benedikt Schworm, Norbert Klugbauer, Christian Grimm, Christian Wahl-Schott, Stylianos Michalakis, Martin Biel

    Yanfen Li ... Martin Biel

    Published 28 June 2021

    This study identifies the endolysosomal two-pore channel TPC2 as a potential novel drug target for age-related macular degeneration (AMD). Inhibition of TPC2 reduces two key clinical hallmarks of the AMD, retinal inflammation and formation of leaky choroi.

  • Concomitant gain and loss of function pathomechanisms in C9ORF72 amyotrophic lateral sclerosis
    Open Access
    Concomitant gain and loss of function pathomechanisms in C9ORF72 amyotrophic lateral sclerosis

    Arun Pal, Benedikt Kretner, Masin Abo-Rady, Hannes Glaβ, Banaja P Dash, Marcel Naumann, Julia Japtok, Nicole Kreiter, Ashutosh Dhingra, Peter Heutink, Tobias M Böckers, René Günther, Jared Sterneckert, Andreas Hermann

    Arun Pal ... Andreas Hermann

    Published 22 February 2021

    Axonal trafficking deficits and neurodegeneration in C9ORF72 motoneurons are mediated by GOF and LOF mechanisms with RNA foci and DPRs as upstream events, whereas DNA damage appears downstream.

  • Reduced RNA turnover as a driver of cellular senescence
    Open Access
    Reduced RNA turnover as a driver of cellular senescence

    Nowsheen Mullani, Yevheniia Porozhan, Adèle Mangelinck, Christophe Rachez, Mickael Costallat, Eric Batsché, Michele Goodhardt, Giovanni Cenci, Carl Mann, Christian Muchardt

    Nowsheen Mullani ... Christian Muchardt

    Published 14 January 2021

    RNAs originating from transcription upstream and downstream of genes accumulate in the cytoplasm of a subset of senescent cells, suggesting an RNA alternative to cytoplasmic DNA in the triggering of senescence.

  • PGE<sub>2</sub> accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smoking
    Open Access
    PGE2 accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smoking

    Loka R Penke, Jennifer M Speth, Christina Draijer, Zbigniew Zaslona, Judy Chen, Peter Mancuso, Christine M Freeman, Jeffrey L Curtis, Daniel R Goldstein, Marc Peters-Golden

    Loka R Penke ... Marc Peters-Golden

    Published 20 August 2020

    Dysregulation of self-renewal contributes to alterations in alveolar macrophages (AMs). In this study, Penke et al identify PGE2 as a suppressor of AM proliferation, whose divergent bioavailability in aged and cigarette smoke-exposed mice could explain opposite effects on AM numbers.

  • Profiles of histidine-rich glycoprotein associate with age and risk of all-cause mortality
    Open Access
    Profiles of histidine-rich glycoprotein associate with age and risk of all-cause mortality

    Mun-Gwan Hong, Tea Dodig-Crnković, Xu Chen, Kimi Drobin, Woojoo Lee, Yunzhang Wang, Fredrik Edfors, David Kotol, Cecilia Engel Thomas, Ronald Sjöberg, Jacob Odeberg, Anders Hamsten, Angela Silveira, Per Hall, Peter Nilsson, Yudi Pawitan, Mathias Uhlén, Nancy L Pedersen, Sara Hägg, Patrik KE Magnusson, Jochen M Schwenk

    Mun-Gwan Hong ... Jochen M Schwenk

    Published 31 July 2020

    Affinity-based proteomics assays identify particular profiles of the circulating histidine-rich glycoprotein to increase with age and elevated levels to indicate a higher risk of all-cause mortality.

  • USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation
    Open Access
    USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation

    Emma V Rusilowicz-Jones, Jane Jardine, Andreas Kallinos, Adan Pinto-Fernandez, Franziska Guenther, Mariacarmela Giurrandino, Francesco G Barone, Katy McCarron, Christopher J Burke, Alejandro Murad, Aitor Martinez, Elena Marcassa, Malte Gersch, Alexandre J Buckmelter, Katherine J Kayser-Bricker, Frederic Lamoliatte, Akshada Gajbhiye, Simon Davis, Hannah C Scott, Emma Murphy, Katherine England, Heather Mortiboys, David Komander, Matthias Trost, Benedikt M Kessler, Stephanos Ioannidis, Michael K Ahlijanian, Sylvie Urbé, Michael J Clague

    Emma V Rusilowicz-Jones ... Michael J Clague

    Published 7 July 2020

    A new inhibitor of the deubiquitylase USP30, an actionable target relevant to Parkinson’s Disease, is introduced and characterised for parameters related to mitophagy.

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