Aging
Apolipoprotein E intersects with amyloid-β within neuronsApolipoprotein E4, the most important genetic risk factor for Alzheimer's disease, is shown to internalize into neurons and intersect with amyloid-β in endosomes–autophagosomes of neurites and modulate intraneuronal amyloid-β-42.
Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brainPleiotropic consequences of deletion of SERF in mice reveals biological functions in cell growth and development and supports the existence of biological modifiers of amyloid polymorphisms in the brain.
Sleep–wake patterns are altered with age, Prdm13 signaling in the DMH, and diet restriction in miceThis study found that age-associated sleep changes are ameliorated by DR in the presence of Prdm13 signaling in the DMH, suggesting Prdm13+ DMH neurons will be of great interest to explore a potential intervention on age-associated sleep changes.
MicroRNAs in tear fluids predict underlying molecular changes associated with Alzheimer’s diseaseThis study demonstrated the translational potential of deregulated tear fluid miRNAs associated with amyloid beta production and proinflammation in a transgenic AD mouse model.
Regulation of telomere silencing by the core histones–autophagy–Sir2 axisThis work reported that there is a global loss of core histones and progressively reduced telomere silencing during yeast chronological aging and uncovered the core histones-autophagy-Sir2 pathway that contributes to the aging-coupled loss of telomere silencing.
Lack of peroxisomal catalase affects heat shock response in Caenorhabditis elegansThe authors present a previously unknown crosstalk between peroxisomes and the heat shock response, whereby the peroxisomal catalase is vital for cellular capacity to survive heat stress and undergo heat-induced lifespan extension.
Timapiprant, a prostaglandin D2 receptor antagonist, ameliorates pathology in a rat Alzheimer’s modelPGD2 is a major brain prostaglandin and we report that timapiprant that is an antagonist for the PGD2 receptor DP2 reduces pathology and cognitive deficits in a transgenic rat model of Alzheimer’s.
Mesenchymal stem cells derived from patients with premature aging syndromes display hallmarks of physiological agingUsing of genome-wide approaches on models from laminopathies with or without progerin accumulation (HGPS, HGPS-L, APS), this study provides new insights on pathways altered during early stages of mesenchymal stem cells differentiation.
Reduced adhesion of aged intestinal stem cells contributes to an accelerated clonal driftAnalysis of clonal dynamics of intestinal stem cells supports an accelerated clonal drift upon aging, likely because of reduced adhesion of aged ISCs because of reduced canonical Wnt signaling.
Loss of SET1/COMPASS methyltransferase activity reduces lifespan and fertility in Caenorhabditis elegansContrary to prior reports, this study shows that a loss of COMPASS components or SET1 activity reduces Caenorhabditis elegans lifespan, suggesting that as in yeast, H3K4 methylation is essential for normal longevity.