Newest Articles
A fluorescent sensor for real-time monitoring of DPP8/9 reveals crucial roles in immunity and cancerWeiss et al developed a genetically encoded biosensor for real-time monitoring of DPP8/9 activity, an important protease, and revealed roles of DPP8/9 in B-cell maturation and melanoma proliferation.
AAV2-driven endothelin induces chronic reduced retinal blood flow/retinal ganglion cell loss in ratsHere, we established an animal model of chronic ocular blood flow reduction to mimic glaucoma. We found that this animal model has retinal ganglion cell loss without intraocular pressure elevation.
AURKA controls oocyte spindle assembly checkpoint and chromosome alignment by HEC1 phosphorylationAurora kinase A regulates kinetochore function by phosphorylating HEC1 at serine 69 in mouse oocytes undergoing completion of meiosis I, contributing to SAC activation and chromosome alignment.
SLC38A9 is directly involved in Tat-induced endolysosome dysfunction and senescence in astrocytesInternalized HIV Tat interacts with endolysosome-resident SLC38A9 via the arginine-rich domain, and such an interaction leads to endolysosome dysfunction and cellular senescence in human astrocytes.
DNA methylation predicts infection risk in kidney transplant recipientsThis study analyzed DNA methylation perturbations in patients after kidney transplantation, revealing the infection risk can be predicted using DNA methylation profiles.
CLCa mediates a novel cross-talk between Wnt secretion and actin organizationThe clathrin light chain, CLCa, regulates Wnt secretion in a WLS-dependent manner. Furthermore, CLCa drives actin organization and participates in its cross-talk with Wnt signaling in mammalian cells.
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