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The spread of SARS-CoV-2 continues to quickly evolve in many countries, and many research institutions have been subject to temporary shutdowns.
Life Science Alliance remains fully functional and will continue to publish as before and is open to submissions, as well as presubmission or any other inquiries, such as reaching out to us with reviewer reports obtained at another journal.
Our staff is working remotely and is reachable via email and phone
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  • Insulin signaling mediates neurodegeneration in glioma
  • Paneth cell–derived growth factors support tumorigenesis in the small intestine
  • DNMT1 function in T cell lymphoma
  • Regulation of SC formation by SCF
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Newest Articles

  • Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastoma
    Open Access
    Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastoma

    Elena A Afanasyeva, Moritz Gartlgruber, Tatsiana Ryl, Bieke Decaesteker, Geertrui Denecker, Gregor Mönke, Umut H Toprak, Andres Florez, Alica Torkov, Daniel Dreidax, Carl Herrmann, Konstantin Okonechnikov, Sara Ek, Ashwini Kumar Sharma, Vitaliya Sagulenko, Frank Speleman, Kai-Oliver Henrich, Frank Westermann

    Elena A Afanasyeva ... Frank Westermann

    Published 3 March 2021

    Video and gene expression analyses coupled with the RNAi technique reveal microtubule-dependent, neuronal-like nucleokinetic migration in a noradrenergic type of neuroblastoma, providing a glimpse into the mechanism by which noradrenergic neuroblastoma cells may spread.

  • The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets
    Open Access
    The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets

    Mariano F Zacarías-Fluck, Toni Jauset, Sandra Martínez-Martín, Jastrinjan Kaur, Sílvia Casacuberta-Serra, Daniel Massó-Vallés, Erika Serrano del Pozo, Génesis Martín-Fernández, Íñigo González-Larreategui, Sergio López-Estévez, Lamorna Brown-Swigart, Marie-Eve Beaulieu, Jonathan R Whitfield, Babita Madan, David M Virshup, Gerard I Evan, Laura Soucek

    Mariano F Zacarías-Fluck ... Laura Soucek

    Published 2 March 2021

    Zacarías-Fluck, et al identify and validate the Wnt receptor Fzd9 as a key effector of Myc-Wnt signaling cross-talk in a mouse model of Myc-driven pancreatic insulinomas.

  • nNOS regulates ciliated cell polarity, ciliary beat frequency, and directional flow in mouse trachea
    Open Access
    nNOS regulates ciliated cell polarity, ciliary beat frequency, and directional flow in mouse trachea

    Anatoly Mikhailik, Tatyana V Michurina, Krikor Dikranian, Stephen Hearn, Vladimir I Maxakov, Saul S Siller, Ken-Ichi Takemaru, Grigori Enikolopov, Natalia Peunova

    Anatoly Mikhailik ... Natalia Peunova

    Published 2 March 2021

    Directional flow of mucus across the mucociliary epithelium enables the clearance of the airway. This study shows that nNOS supports the flow by regulating the planar polarity and ciliary beat frequency of ciliated cells in the tracheal epithelium.

  • Concomitant gain and loss of function pathomechanisms in C9ORF72 amyotrophic lateral sclerosis
    Open Access
    Concomitant gain and loss of function pathomechanisms in C9ORF72 amyotrophic lateral sclerosis

    Arun Pal, Benedikt Kretner, Masin Abo-Rady, Hannes Glaβ, Banaja P Dash, Marcel Naumann, Julia Japtok, Nicole Kreiter, Ashutosh Dhingra, Peter Heutink, Tobias M Böckers, René Günther, Jared Sterneckert, Andreas Hermann

    Arun Pal ... Andreas Hermann

    Published 22 February 2021

    Axonal trafficking deficits and neurodegeneration in C9ORF72 motoneurons are mediated by GOF and LOF mechanisms with RNA foci and DPRs as upstream events, whereas DNA damage appears downstream.

  • Renal CD169<sup>++</sup> resident macrophages are crucial for protection against acute systemic candidiasis
    Open Access
    Renal CD169++ resident macrophages are crucial for protection against acute systemic candidiasis

    Yi Juan Teo, See Liang Ng, Keng Wai Mak, Yolanda Aphrilia Setiagani, Qi Chen, Sajith Kumar Nair, Jianpeng Sheng, Christiane Ruedl

    Yi Juan Teo ... Christiane Ruedl

    Published 19 February 2021

    A renal CD169++ resident macrophage subpopulation controls Candida albicans growth, severe kidney inflammation, and immunopathology during acute systemic candidiasis.

  • GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification program
    Open Access
    GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification program

    Yoji Kojima, Chika Yamashiro, Yusuke Murase, Yukihiro Yabuta, Ikuhiro Okamoto, Chizuru Iwatani, Hideaki Tsuchiya, Masataka Nakaya, Tomoyuki Tsukiyama, Tomonori Nakamura, Takuya Yamamoto, Mitinori Saitou

    Yoji Kojima ... Mitinori Saitou

    Published 19 February 2021

    This work shows that GATA transcription factors transduce the BMP signaling and, with SOX17 and TFAP2C, induce the human germ-cell fate, delineating the mechanism for human germ-cell specification.

View more latest articles

About Life Science Alliance

Life Science Alliance is an international, open-access, editorially independent, and peer-reviewed journal launched by an alliance of three preeminent scientific organizations: EMBO, Rockefeller University, and Cold Spring Harbor Laboratory. Life Science Alliance is committed to the rapid, fair, and transparent publication of research papers, resources, and new methods from the full spectrum of life science and biomedical research.

Life Science Alliance LLC is limited liability non-stock corporation jointly owned by Cold Spring Harbor Laboratory, EMBO Press Innovations gGmbH and The Rockefeller University and incorporated in the State of Delaware, USA, with company number 6706208.

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Volume 4, No. 2
February 2021
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