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  • LSA Immunology Collection 2022
    Browse original findings on COVID-19, T cell function and immune response to viral infection, and more
  • Rab11 endosomes and Pericentrin coordinate centrosome movement during pre-abscission in vivo
  • AGO1 regulates pericentromeric regions in mouse embryonic stem cells
  • β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy
  • Cancer Cell Biology
    The latest advances in cell biology published in LSA.
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Newest Articles

  • Distinct landscapes of deleterious variants in DNA damage repair system in ethnic human populations
    Open Access

    Research Article

    Distinct landscapes of deleterious variants in DNA damage repair system in ethnic human populations

    Zixin Qin, Teng Huang, Maoni Guo, San Ming Wang

    Zixin Qin ... San Ming Wang

    Published 20 May 2022

    Deleterious variants in the DNA damage repair system can cause genome instability and increase cancer risk. The highly ethnic-specific DDR deleterious variation from this study suggests its potential relationship with different disease susceptibility in ethnic human populations.

  • DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF
    Open Access

    Research Article

    DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF

    Nuria Gutierrez-Prat, Hedwig L Zuberer, Luca Mangano, Zahra Karimaddini, Luise Wolf, Stefka Tyanova, Lisa C Wellinger, Daniel Marbach, Vera Griesser, Piergiorgio Pettazzoni, James R Bischoff, Daniel Rohle, Chiara Palladino, Igor Vivanco

    Nuria Gutierrez-Prat ... Igor Vivanco

    Published 17 May 2022

    Our study demonstrates that in BRAF- and NRAS-mutant MITF-proficient melanoma, the DUSP4 MAPK phosphatase restricts MAPK activation and prevents oncogenic overdose through modulation of MITF function.

  • Expression regulation of genes is linked to their CpG density distributions around transcription start sites
    Open Access

    Research Article

    Expression regulation of genes is linked to their CpG density distributions around transcription start sites

    Hao Tian, Yueying He, Yue Xue, Yi Qin Gao

    Hao Tian ... Yi Qin Gao

    Published 17 May 2022

    In this work, we performed a gene classification which revealed that different gene clusters harbor distinct gene regulatory mechanisms as well as epigenetic mark and expression variations in tumorigenesis.

  • Lack of Hikeshi activates HSF1 activity under normal conditions and disturbs the heat-shock response
    Open Access

    Research Article

    Lack of Hikeshi activates HSF1 activity under normal conditions and disturbs the heat-shock response

    Shingo Kose, Kenichiro Imai, Ai Watanabe, Akira Nakai, Yutaka Suzuki, Naoko Imamoto

    Shingo Kose ... Naoko Imamoto

    Published 17 May 2022

    Hikeshi mediates proper nucleocytoplasmic distribution of HSP70, which is important for regulating of HSF1 activity and nuclear proteostasis, and adaptive response to heat shock.

  • The HDL particle composition determines its antitumor activity in pancreatic cancer
    Open Access

    Research Article

    The HDL particle composition determines its antitumor activity in pancreatic cancer

    Raimund Oberle, Kristina Kührer, Tamina Österreicher, Florian Weber, Stefanie Steinbauer, Florian Udonta, Mark Wroblewski, Isabel Ben-Batalla, Ingrid Hassl, Jakob Körbelin, Matthias Unseld, Matti Jauhiainen, Birgit Plochberger, Clemens Röhrl, Markus Hengstschläger, Sonja Loges, Herbert Stangl

    Raimund Oberle ... Herbert Stangl

    Published 16 May 2022

    The authors show that particle composition–dependent, efficient HDL-mediated cholesterol depletion induces apoptosis and interferes with the aggressive growth characteristics of pancreatic cancer cells.

  • Nuclear ingression of cytoplasmic bodies accompanies a boost in autophagy
    Open Access

    Research Article

    Nuclear ingression of cytoplasmic bodies accompanies a boost in autophagy

    Manon Garcia, Sylvain Kumanski, Alberto Elías-Villalobos, Chantal Cazevieille, Caroline Soulet, María Moriel-Carretero

    Manon Garcia ... María Moriel-Carretero

    Published 13 May 2022

    We describe a fully new remodeling event of the nuclear envelope surrounding the nucleolus: it partitions into its regular contact with the vacuole and a dramatic internalization of globular cytoplasmic portions within the nucleus.

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About Life Science Alliance

Life Science Alliance is an international, open-access, editorially independent, and peer-reviewed journal launched by an alliance of three preeminent scientific organizations: EMBO, Rockefeller University, and Cold Spring Harbor Laboratory. Life Science Alliance is committed to the rapid, fair, and transparent publication of research papers, resources, and new methods from the full spectrum of life science and biomedical research.

Life Science Alliance LLC is limited liability non-stock corporation jointly owned by Cold Spring Harbor Laboratory, EMBO Press Innovations gGmbH and The Rockefeller University and incorporated in the State of Delaware, USA, with company number 6706208.

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Volume 5, No. 5
May 2022
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