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Accelerating publication Papers may be submitted directly or transferred from journals published by the alliance partners. |
Newest Articles
PRDM9 forms a trimer by interactions within the zinc finger arrayPRDM9 forms a trimer as a soluble protein and in complex with DNA mediated by the ZnF domain. Five ZnFs are already sufficient for multimerization and only one DNA molecule is complexed in the trimer.
Membrane curvature sensing of the lipid-anchored K-Ras small GTPaseProteolipid nanoassemblies of K-Ras and lipids in the plasma membrane sense changing membrane curvature architecture and convert mechanical perturbations to mitogenic signaling.
Human DNA polymerase delta requires an iron–sulfur cluster for high-fidelity DNA synthesisThe iron–sulfur cluster in human DNA polymerase delta has an impact on DNA polymerase and exonuclease activities and can hence influence the fidelity of DNA synthesis.
Systematic identification of recognition motifs for the hub protein LC8LC8 is a eukaryotic hub protein that interacts with multifarious partners; analysis of more than 100 binding/nonbinding sequences led to an algorithm that predicts LC8 partners with 78% accuracy.
Fibril-induced glutamine-/asparagine-rich prions recruit stress granule proteins in mammalian cellsThis study provides evidence that exogenous proteinaceous seeds can induce protein aggregates that sequester stress granule components independent of stress granule assembly.
De novo prediction of cell-type complexity in single-cell RNA-seq and tumor microenvironmentsThis study describes a computational method for determining statistical support to varying levels of heterogeneity provided by single-cell RNA-sequencing data with applications to tumor samples.
About Life Science Alliance
Life Science Alliance is a new international, open-access, editorially independent, and peer-reviewed journal launched by an alliance of three preeminent scientific organizations: EMBO, Rockefeller University, and Cold Spring Harbor Laboratory. Life Science Alliance is committed to the rapid, fair, and transparent publication of research papers, resources, and new methods from the full spectrum of life science and biomedical research.
