Newest Articles
Nodal and churchill1 position the expression of a notch ligand during Xenopus germ layer segregationChurchill and Nodal signaling, which participate in vertebrates’ germ layer induction, position a domain of Delta/Notch activity, which refines germ layer boundaries during frog gastrulation.
Synthetic evolution of herbicide resistance using a T7 RNAP–based random DNA base editorA chimeric fusion of T7 RNAP and deaminase edits the DNA under the T7 promoter in plant cells. It directs the continuous synthetic evolution of OsALS to produce variants with herbicide resistance.
Timapiprant, a prostaglandin D2 receptor antagonist, ameliorates pathology in a rat Alzheimer’s modelPGD2 is a major brain prostaglandin and we report that timapiprant that is an antagonist for the PGD2 receptor DP2 reduces pathology and cognitive deficits in a transgenic rat model of Alzheimer’s.
Building in vitro models of the brain to understand the role of APOE in Alzheimer’s diseaseHuman induced pluripotent stem cell (hiPSC)–based models of the brain will be key to unraveling the role of APOE ɛ4 in the interconnected cellular changes underlying Alzheimer’s disease.
miR-329– and miR-495–mediated Prr7 down-regulation is required for homeostatic synaptic depression in rat hippocampal neuronsIn rat hippocampal neurons, miRNA-dependent regulation of the synaptic Prr7 protein is required for the homeostatic synaptic depression of excitatory synapses upstream of the CDK5-SPAR pathway.
Regulation of Liprin-α phase separation by CASK is disrupted by a mutation in its CaM kinase domainMutations in the human CASK gene cause a neurodevelopmental disorder; we show that CASK regulates condensate formation of Liprin-alpha 2 and that patient mutations in the CaM kinase domain interfere with Liprin binding and regulation of condensate formation.
About Life Science Alliance
Life Science Alliance is an international, open-access, editorially independent, and peer-reviewed journal launched by an alliance of three preeminent scientific organizations: EMBO, Rockefeller University, and Cold Spring Harbor Laboratory. Life Science Alliance is committed to the rapid, fair, and transparent publication of research papers, resources, and new methods from the full spectrum of life science and biomedical research.
Life Science Alliance LLC is limited liability non-stock corporation jointly owned by Cold Spring Harbor Laboratory, EMBO Press Innovations gGmbH and The Rockefeller University and incorporated in the State of Delaware, USA, with company number 6706208.
