Newest Articles
ER targeting of non-imported mitochondrial carrier proteins is dependent on the GET pathwayThe GET pathway is required to target non-imported mitochondrial carrier proteins to the endoplasmic reticulum, which prevents their deposition into Hsp42-dependent protein foci.
Reduced RNA turnover as a driver of cellular senescenceRNAs originating from transcription upstream and downstream of genes accumulate in the cytoplasm of a subset of senescent cells, suggesting an RNA alternative to cytoplasmic DNA in the triggering of senescence.
MALDI-IMS combined with shotgun proteomics identify and localize new factors in male infertilityIn situ proteomics of male infertility.
Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1Main mitotic kinases as PLK1 are activated at the S/G2 transition. A change in Cyclin A2 localisation at the S/G2 transition enables activation of PLK1.
Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectoriesUsing integrated genome-wide and phenotypic methods this study investigates four different mutant RUNX1 oncoproteins and reveals how they differentially contribute to aberrant haematopoiesis.
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