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  • DKC1 in tumor metabolism and metastasis
  • FTSJ1 role in neuron morphology & learning performance
  • S417 is critical for function of STIM1
  • endosomal rewiring during starvation
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Newest Articles

  • The organizer of chromatin topology RIF1 ensures cellular resilience to DNA replication stress
    Research Article
    Open Access
    The organizer of chromatin topology RIF1 ensures cellular resilience to DNA replication stress

    Rana Lebdy, Julie Patouillard, Marion Larroque, Serge Urbach, Raghida Abou Merhi, Christian Larroque, Cyril Ribeyre

    Rana Lebdy ... Cyril Ribeyre

    Published 6 February 2023

    The conserved protein RIF1 stabilizes replication factories and regulates cohesin recruitment in response to replication stress to limit DNA lesions.

  • Inflammasome-independent NLRP3 function enforces ATM activity in response to genotoxic stress
    Research Article
    Open Access
    Inflammasome-independent NLRP3 function enforces ATM activity in response to genotoxic stress

    Mélanie Bodnar-Wachtel, Anne-Laure Huber, Julie Gorry, Sabine Hacot, Delphine Burlet, Laetitia Gérossier, Baptiste Guey, Nadège Goutagny, Birke Bartosch, Elise Ballot, Julie Lecuelle, Caroline Truntzer, François Ghiringhelli, Bénédicte F Py, Yohann Couté, Annabelle Ballesta, Sylvie Lantuejoul, Janet Hall, Agnès Tissier, Virginie Petrilli

    Mélanie Bodnar-Wachtel ... Virginie Petrilli

    Published 6 February 2023

    This study reports that NLRP3 is down-regulated in cancers and identifies a novel non-immune function for NLRP3 in maintaining genome integrity through the control of ATM activation in response to DSB.

  • A practical comparison of the next-generation sequencing platform and assemblers using yeast genome
    Resource
    Open Access
    A practical comparison of the next-generation sequencing platform and assemblers using yeast genome

    Min-Seung Jeon, Da Min Jeong, Huijeong Doh, Hyun Ah Kang, Hyungtaek Jung, Seong-il Eyun

    Min-Seung Jeon ... Seong-il Eyun

    Published 6 February 2023

    This research analyzes the general and optimal de novo yeast assembly pipeline using the repetitive yeast genome assembly by benchmarking four different sequencing platforms and seven assembly programs.

  • Epigenetic signals that direct cell type–specific interferon beta response in mouse cells
    Research Article
    Open Access
    Epigenetic signals that direct cell type–specific interferon beta response in mouse cells

    Markus Muckenhuber, Isabelle Seufert, Katharina Müller-Ott, Jan-Philipp Mallm, Lara C Klett, Caroline Knotz, Jana Hechler, Nick Kepper, Fabian Erdel, Karsten Rippe

    Markus Muckenhuber ... Karsten Rippe

    Published 2 February 2023

    Preexisting cell type–specific chromatin features represent an additional regulatory layer for interferon beta response and direct binding of STAT transcription factors and gene induction.

  • Loss of dyskerin facilitates the acquisition of metastatic traits by altering the mevalonate pathway
    Research Article
    Open Access
    Loss of dyskerin facilitates the acquisition of metastatic traits by altering the mevalonate pathway

    Evelyn Andrades, Agustí Toll, Gustavo Deza, Sonia Segura, Ramón Gimeno, Guadalupe Espadas, Eduard Sabidó, Noemí Haro, Óscar J Pozo, Marta Bódalo, Paloma Torres, Ramon M Pujol, Inmaculada Hernández-Muñoz

    Evelyn Andrades ... Inmaculada Hernández-Muñoz

    Published 2 February 2023

    Cholesterol metabolism may be involved in the early steps of tumor dissemination. Epigenetic regulation of cholesterol synthesis and uptake is of great importance in this process and may constitute a vulnerability of the cancer cell that could be exploited pharmacologically.

  • Plant mobile domain proteins ensure Microrchidia 1 expression to fulfill transposon silencing
    Research Article
    Open Access
    Plant mobile domain proteins ensure Microrchidia 1 expression to fulfill transposon silencing

    Lucas Jarry, Julie Descombin, Melody Nicolau, Ange Dussutour, Nathalie Picault, Guillaume Moissiard

    Lucas Jarry ... Guillaume Moissiard

    Published 2 February 2023

    The plant mobile domain proteins MAIN and MAIL1 control the expression of the epigenetic factor Microrchidia 1, which has been involved in transposable element silencing in Arabidopsis.

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About Life Science Alliance

Life Science Alliance is an international, open-access, editorially independent, and peer-reviewed journal launched by an alliance of three preeminent scientific organizations: EMBO, Rockefeller University, and Cold Spring Harbor Laboratory. Life Science Alliance is committed to the rapid, fair, and transparent publication of research papers, resources, and new methods from the full spectrum of life science and biomedical research.

Life Science Alliance LLC is limited liability non-stock corporation jointly owned by Cold Spring Harbor Laboratory, EMBO Press Innovations gGmbH and The Rockefeller University and incorporated in the State of Delaware, USA, with company number 6706208.

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Volume 6, No. 2
February 2023
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  • Linking medicinal cannabis to autotaxin–LPA signaling
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