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The spread of SARS-CoV-2 continues to quickly evolve in many countries, and many research institutions have been subject to temporary shutdowns.
Life Science Alliance remains fully functional and will continue to publish as before and is open to submissions, as well as presubmission or any other inquiries, such as reaching out to us with reviewer reports obtained at another journal.
Our staff is working remotely and is reachable via email and phone
.
  • Cancer Biology 2021 special collection
    Special collection covering genetic, immune, and metabolic influences on tumor development and progression
  • The AXL-PYK2-PKCα axis as a nexus of stemness circuits in TNBC
  • Mapping the micro-proteome of the nuclear lamina and lamina-associated domains
  • nNOS regulates ciliated cell polarity, ciliary beat frequency, and directional flow in mouse trachea
  • Paneth cell–derived growth factors support tumorigenesis in the small intestine
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Newest Articles

  • NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation
    Open Access
    NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation

    Snehlata Kumari, Trieu-My Van, Daniela Preukschat, Hannah Schuenke, Marijana Basic, André Bleich, Ulf Klein, Manolis Pasparakis

    Snehlata Kumari ... Manolis Pasparakis

    Published 15 April 2021

    TNFR1 was found to cause skin inflammation in mice with epidermal keratinocyte-specific ablation of IKK2 or of both the NF-kB subunits RelA and cRel by triggering RIPK1-dependent, RIPK3-MLKL–mediated necroptosis of keratinocytes.

  • Proteomics characterisation of the L929 cell supernatant and its role in BMDM differentiation
    Open Access
    Proteomics characterisation of the L929 cell supernatant and its role in BMDM differentiation

    Rachel E Heap, José Luis Marín-Rubio, Julien Peltier, Tiaan Heunis, Abeer Dannoura, Adam Moore, Matthias Trost

    Rachel E Heap ... Matthias Trost

    Published 14 April 2021

    L929 cell supernatant is commonly used to differentiate murine macrophages from bone marrow. The supernatant and its effect on macrophage phenotype was characterised by proteomics and the authors identified novel immunoregulatory proteins.

  • In utero exposure to chlordecone affects histone modifications and activates LINE-1 in cord blood
    Open Access
    In utero exposure to chlordecone affects histone modifications and activates LINE-1 in cord blood

    Louis Legoff, Shereen Cynthia D’Cruz, Katia Bouchekhchoukha, Christine Monfort, Christian Jaulin, Luc Multigner, Fatima Smagulova

    Louis Legoff ... Fatima Smagulova

    Published 9 April 2021

    In utero exposure to chlordecone affects chromatin and leads to activation of retroelements. This study shows the changes induced by chlordecone in human umbilical cord blood and blood-derived cell line.

  • Crystal structure of inhibitor-bound human MSPL that can activate high pathogenic avian influenza
    Open Access
    Crystal structure of inhibitor-bound human MSPL that can activate high pathogenic avian influenza

    Ayako Ohno, Nobuo Maita, Takanori Tabata, Hikaru Nagano, Kyohei Arita, Mariko Ariyoshi, Takayuki Uchida, Reiko Nakao, Anayt Ulla, Kosuke Sugiura, Koji Kishimoto, Shigetada Teshima-Kondo, Yuushi Okumura, Takeshi Nikawa

    Ayako Ohno ... Takeshi Nikawa

    Published 5 April 2021

    The structure of extracellular domain of MSPL and inhibitor complex helps to understand the TTSP functions, including TMPRSS2, and provides the insights of the infection of influenza and SARS-CoV.

  • Mitochondrial Aurora kinase A induces mitophagy by interacting with MAP1LC3 and Prohibitin 2
    Open Access
    Mitochondrial Aurora kinase A induces mitophagy by interacting with MAP1LC3 and Prohibitin 2

    Giulia Bertolin, Marie-Clotilde Alves-Guerra, Angélique Cheron, Agnès Burel, Claude Prigent, Roland Le Borgne, Marc Tramier

    Giulia Bertolin ... Marc Tramier

    Published 5 April 2021

    The multifunctional Ser/Thr kinase AURKA uses the Inner Mitochondrial Membrane receptor PHB2 and MAP1LC3 as a signalling platform to orchestrate the elimination of dysfunctional mitochondria.

  • Replicated chromatin curtails 53BP1 recruitment in BRCA1-proficient and BRCA1-deficient cells
    Open Access
    Replicated chromatin curtails 53BP1 recruitment in BRCA1-proficient and BRCA1-deficient cells

    Jone Michelena, Stefania Pellegrino, Vincent Spegg, Matthias Altmeyer

    Jone Michelena ... Matthias Altmeyer

    Published 2 April 2021

    This study demonstrates how single cell normalization to genome size provides insight into genome function, here in the context of DNA double-strand break repair by 53BP1 versus BRCA1–BARD1.

View more latest articles

About Life Science Alliance

Life Science Alliance is an international, open-access, editorially independent, and peer-reviewed journal launched by an alliance of three preeminent scientific organizations: EMBO, Rockefeller University, and Cold Spring Harbor Laboratory. Life Science Alliance is committed to the rapid, fair, and transparent publication of research papers, resources, and new methods from the full spectrum of life science and biomedical research.

Life Science Alliance LLC is limited liability non-stock corporation jointly owned by Cold Spring Harbor Laboratory, EMBO Press Innovations gGmbH and The Rockefeller University and incorporated in the State of Delaware, USA, with company number 6706208.

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Volume 4, No. 3
March 2021
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