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  • Knock-in method enabling lineage tracing
  • Multiplexed kinase siRNA screen for glia phenotype
  • Matrix Mg2+ autoinhibits MRS2
  • Rab1A-HVD in autophagy
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Newest Articles

  • Interaction hub critical for telomerase recruitment and primer-template handling for catalysis
    Research Article
    Open Access
    Interaction hub critical for telomerase recruitment and primer-template handling for catalysis

    Shilpa Padmanaban, Valerie M Tesmer, Jayakrishnan Nandakumar

    Shilpa Padmanaban ... Jayakrishnan Nandakumar

    Published 24 March 2023

    By deleting, mutating, and adding back parts of the telomerase enzyme that extends chromosome ends, we uncover features important for its proper functioning in the cell.

  • Characterisation of the OTU domain deubiquitinase complement of <em>Toxoplasma gondii</em>
    Research Article
    Open Access
    Characterisation of the OTU domain deubiquitinase complement of Toxoplasma gondii

    Mary-Louise Wilde, Ushma Ruparel, Theresa Klemm, V Vern Lee, Dale J Calleja, David Komander, Christopher J Tonkin

    Mary-Louise Wilde ... Christopher J Tonkin

    Published 23 March 2023

    The OTU deubiquitinase family is expanded in Toxoplasma parasites, and members show preferences for Lys6-, Lys11-, Lys48-, and Lys63-linked ubiquitin chains, and additional specificity for NEDD8. AlphaFold-guided structural analysis reveals cryptic ubiquitin-binding domains with functional importance.

  • Filopodia-like protrusions of adjacent somatic cells shape the developmental potential of oocytes
    Research Article
    Open Access
    Filopodia-like protrusions of adjacent somatic cells shape the developmental potential of oocytes

    Flora Crozet, Gaëlle Letort, Rose Bulteau, Christelle Da Silva, Adrien Eichmuller, Anna Francesca Tortorelli, Joséphine Blévinal, Morgane Belle, Julien Dumont, Tristan Piolot, Aurélien Dauphin, Fanny Coulpier, Alain Chédotal, Jean-Léon Maître, Marie-Hélène Verlhac, Hugh J Clarke, Marie-Emilie Terret

    Flora Crozet ... Marie-Emilie Terret

    Published 21 March 2023

    Filopodia-like protrusions sent by the somatic cells to the oocyte play a role in the structural integrity of the germline–somatic complex, and regulate gene expression in the oocyte and thus its developmental potential and chances to produce a viable embryo.

  • Cell death and barrier disruption by clinically used iodine concentrations
    Research Article
    Open Access
    Cell death and barrier disruption by clinically used iodine concentrations

    Anne Steins, Christina Carroll, Fui Jiun Choong, Amee J George, Jin-Shu He, Kate M Parsons, Shouya Feng, Si Ming Man, Cathelijne Kam, Lex M van Loon, Perlita Poh, Rita Ferreira, Graham J Mann, Russell L Gruen, Katherine M Hannan, Ross D Hannan, Klaus-Martin Schulte

    Anne Steins ... Klaus-Martin Schulte

    Published 21 March 2023

    Clinically used concentrations of povidone-iodine (PVP-I) are toxic to eukaryotic cells by attacking the lipid bilayer and tight junctions with fast kinetics and urge the reappraisal of PVP-I use.

  • H4K20me1 plays a dual role in transcriptional regulation of regeneration and axis patterning in <em>Hydra</em>
    Research Article
    Open Access
    H4K20me1 plays a dual role in transcriptional regulation of regeneration and axis patterning in Hydra

    Akhila Gungi, Shagnik Saha, Mrinmoy Pal, Sanjeev Galande

    Akhila Gungi ... Sanjeev Galande

    Published 21 March 2023

    H4K20me1 modification by SETD8 methyltransferase is typically associated with repression. In Hydra, it is associated with activation machinery locally at Wnt-responsive promoters indicating its dual role in transcriptional regulation.

  • Structure-based design and characterization of Parkin-activating mutations
    Research Article
    Open Access
    Structure-based design and characterization of Parkin-activating mutations

    Michael U Stevens, Nathalie Croteau, Mohamed A Eldeeb, Odetta Antico, Zhi Wei Zeng, Rachel Toth, Thomas M Durcan, Wolfdieter Springer, Edward A Fon, Miratul MK Muqit, Jean-François Trempe

    Michael U Stevens ... Jean-François Trempe

    Published 20 March 2023

    Parkin, an E3 ubiquitin ligase involved in Parkinson’s disease, is inactive in the basal state and is activated by PINK1 to mediate mitophagy. Here, we characterized 31 mutations and discovered three that activate Parkin and rescue loss of PINK1 phosphorylation.

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Life Science Alliance is an international, open-access, editorially independent, and peer-reviewed journal launched by an alliance of three preeminent scientific organizations: EMBO, Rockefeller University, and Cold Spring Harbor Laboratory. Life Science Alliance is committed to the rapid, fair, and transparent publication of research papers, resources, and new methods from the full spectrum of life science and biomedical research.

Life Science Alliance LLC is limited liability non-stock corporation jointly owned by Cold Spring Harbor Laboratory, EMBO Press Innovations gGmbH and The Rockefeller University and incorporated in the State of Delaware, USA, with company number 6706208.

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Volume 6, No. 3
March 2023
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