Newest Articles
Research Article
HERVH-derived lncRNAs negatively regulate chromatin targeting and remodeling mediated by CHD7Mutations in CHD7 are diagnostic for human CHARGE syndrome. RNAs expressed from the HERVH repeats modulate CHD7 function providing one mechanism for regulation of differentiation of pluripotent cells.
Research Article
SnRNA sequencing defines signaling by RBC-derived extracellular vesicles in the murine heartIn a unique model of fluorescent based mapping of EV recipient cells, RBC-EVs were found to signal to cardiac cells and regulate gene expression in a model of ischemic heart failure.
Research Article
A brain-specific pgc1α fusion transcript affects gene expression and behavioural outcomes in miceThis study shows that loss of a brain-specific fusion isoform of PGC1a leads to up-regulation of genes and motor impairments in mice, suggesting functional differences between PGC1 isoforms in the brain.
Research Article
Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germlineA TPP1 mutation known to cause telomere shortening and bone marrow failure in humans recapitulates telomere loss but results in severe germline defects in mice without impacting murine hematopoiesis.
Research Article
Kinomics platform using GBM tissue identifies BTK as being associated with higher patient survivalBTK is a dominant bioactive kinase expressed within both cancer and immune cells of GBM tissue. Complex cell co-cultures might better model the impact of kinase inhibitors as therapeutics in GBM.
Research Article
Interplay between MPIase, YidC, and PMF during Sec-independent insertion of membrane proteinsCharges in the N-terminal region and the synthesis level of membrane proteins with N-out topology determine YidC and PMF dependencies with the interplay between glycolipid MPIase, YidC, and PMF.
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Life Science Alliance is an international, open-access, editorially independent, and peer-reviewed journal launched by an alliance of three preeminent scientific organizations: EMBO, Rockefeller University, and Cold Spring Harbor Laboratory. Life Science Alliance is committed to the rapid, fair, and transparent publication of research papers, resources, and new methods from the full spectrum of life science and biomedical research.
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