Newest Articles
Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastomaVideo and gene expression analyses coupled with the RNAi technique reveal microtubule-dependent, neuronal-like nucleokinetic migration in a noradrenergic type of neuroblastoma, providing a glimpse into the mechanism by which noradrenergic neuroblastoma cells may spread.
The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic isletsZacarías-Fluck, et al identify and validate the Wnt receptor Fzd9 as a key effector of Myc-Wnt signaling cross-talk in a mouse model of Myc-driven pancreatic insulinomas.
nNOS regulates ciliated cell polarity, ciliary beat frequency, and directional flow in mouse tracheaDirectional flow of mucus across the mucociliary epithelium enables the clearance of the airway. This study shows that nNOS supports the flow by regulating the planar polarity and ciliary beat frequency of ciliated cells in the tracheal epithelium.
Concomitant gain and loss of function pathomechanisms in C9ORF72 amyotrophic lateral sclerosisAxonal trafficking deficits and neurodegeneration in C9ORF72 motoneurons are mediated by GOF and LOF mechanisms with RNA foci and DPRs as upstream events, whereas DNA damage appears downstream.
Renal CD169++ resident macrophages are crucial for protection against acute systemic candidiasisA renal CD169++ resident macrophage subpopulation controls Candida albicans growth, severe kidney inflammation, and immunopathology during acute systemic candidiasis.
GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification programThis work shows that GATA transcription factors transduce the BMP signaling and, with SOX17 and TFAP2C, induce the human germ-cell fate, delineating the mechanism for human germ-cell specification.
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