Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Methods & Resources
    • Author Interviews
    • Archive
    • Subjects
  • Collections
  • Submit
    • Submit a Manuscript
    • Author Guidelines
    • License, Copyright, Fee
    • FAQ
    • Why submit
  • About
    • About Us
    • Editors & Staff
    • Board Members
    • Licensing and Reuse
    • Reviewer Guidelines
    • Privacy Policy
    • Advertise
    • Contact Us
    • LSA LLC
  • Alerts
  • Other Publications
    • EMBO Press
    • The EMBO Journal
    • EMBO reports
    • EMBO Molecular Medicine
    • Molecular Systems Biology
    • Rockefeller University Press
    • Journal of Cell Biology
    • Journal of Experimental Medicine
    • Journal of General Physiology
    • Journal of Human Immunity
    • Cold Spring Harbor Laboratory Press
    • Genes & Development
    • Genome Research

User menu

  • My alerts

Search

  • Advanced search
Life Science Alliance
  • Other Publications
    • EMBO Press
    • The EMBO Journal
    • EMBO reports
    • EMBO Molecular Medicine
    • Molecular Systems Biology
    • Rockefeller University Press
    • Journal of Cell Biology
    • Journal of Experimental Medicine
    • Journal of General Physiology
    • Journal of Human Immunity
    • Cold Spring Harbor Laboratory Press
    • Genes & Development
    • Genome Research
  • My alerts

Life Science Alliance

Advanced Search

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Methods & Resources
    • Author Interviews
    • Archive
    • Subjects
  • Collections
  • Submit
    • Submit a Manuscript
    • Author Guidelines
    • License, Copyright, Fee
    • FAQ
    • Why submit
  • About
    • About Us
    • Editors & Staff
    • Board Members
    • Licensing and Reuse
    • Reviewer Guidelines
    • Privacy Policy
    • Advertise
    • Contact Us
    • LSA LLC
  • Alerts
  • Follow LSA on Bluesky
  • Follow lsa Template on Twitter
  • null
    LSA Immunology Collection 2025
    Original findings on T cell receptor signaling, neutrophils in tuberculosis, the gut microbiome, HIV-infected T cells, and more
  • Read the editorial from LSA Executive Editor Tim Fessenden
    Message from the new Executive Editor Tim Fessenden.
  • Read articles in the LSA Cancer Biology 2025 collection.
    Cancer Biology 2025 Special Collection
    Original findings on metastasis modeling, NUT carcinoma and immunotherapy.
  • Identification of TNFAIP2 as a unique cellular regulator of CSF-1 receptor activation
  • ciBAR1 loss in mice causes laterality defects, pancreatic degeneration, and altered glucose tolerance
  • 1
  • 2
  • 3
  • 4
  • 5

Newest Articles

  • No evidence that human GIGYF2 interacts with GRB10: implications for human disease
    Research Article
    Open Access
    No evidence that human GIGYF2 interacts with GRB10: implications for human disease

    Jung-Hyun Choi, Israel Shpilman, Niaz Mahmood, Shaghayegh Farhangmehr, Ulrich Braunschweig, Nathalia Gomide Cruz, Jun Luo, Reese Jalal Ladak, Angelos Pistofidis, Jiannis Ragoussis, T Martin Schmeing, Seyed Mehdi Jafarnejad, Benjamin J Blencowe, Nahum Sonenberg

    Jung-Hyun Choi ... Nahum Sonenberg

    Published 16 June 2025

    Human GRB10 protein, unlike its mouse counterpart, lacks a PPGΦ motif and cannot bind to GIGYF2. These findings question the published literature that links GRB10/GIGYF2 binding to human disease.

  • hnRNP A1 induces aberrant <em>CFTR</em> exon 9 splicing via a newly discovered ESS element
    Research Article
    Open Access
    hnRNP A1 induces aberrant CFTR exon 9 splicing via a newly discovered ESS element

    Christelle Beaumont, Cristiana Stuani, Ming-Yuan Chou, Huma Shakoor, Maria Zlobina, Veronica Palaggi, Emanuele Buratti, Peter Josef Lukavsky

    Christelle Beaumont ... Peter Josef Lukavsky

    Published 16 June 2025

    Missplicing of CFTR exon 9 requires TDP 43 binding to UG-rich sequences upstream of the 3′ss and hnRNP A1 binding to an ESS element in CFTR exon 9.

  • Transcription arrest induces formation of RNA granules in mitochondria
    Research Article
    Open Access
    Transcription arrest induces formation of RNA granules in mitochondria

    Katja G Hansen, Autum Baxter-Koenigs, Caroline AM Weiss, Erik McShane, L Stirling Churchman

    Katja G Hansen ... L Stirling Churchman

    Published 16 June 2025

    In this study, the spatial distribution of mitochondrial-encoded RNAs is investigated and shows that upon transcription arrest, RNAs form granules that show protectivity for transcripts.

  • The Ragulator complex and lysosomal calcium release are crucial for cell migration
    Research Article
    Open Access
    The Ragulator complex and lysosomal calcium release are crucial for cell migration

    Tatsunori Jo, Kohei Tsujimoto, Takeshi Nakatani, Daiki Nagira, Yutaka Muto, Takehiro Hirayama, Hachiro Konaka, Masato Okada, Hyota Takamatsu, Atsushi Kumanogoh

    Tatsunori Jo ... Atsushi Kumanogoh

    Published 10 June 2025

    Lysosomal calcium efflux via TRPML1 drives leukocyte migration by enhancing Lamtor1–MPRIP interaction, and ouabain improves pathogenic inflammation by disrupting Lamtor1’s lysosomal localization.

  • RalGAP complexes control secretion and primary cilia in pancreatic disease
    Research Article
    Open Access
    RalGAP complexes control secretion and primary cilia in pancreatic disease

    Lisa H Apken, Hannah Barz, Stephanie Beel, Esther Michalke, René Rasche, Archana Verma, Andrea Ricker, Harald Nüsse, Jürgen Klingauf, Kornelius Kerl, Eva Wardelmann, Daniel Kümmel, Konrad Steinestel, Zoltán Pethő, Michael Meisterernst, Andrea Oeckinghaus

    Lisa H Apken ... Andrea Oeckinghaus

    Published 9 June 2025

    Loss of RalGAP impacts secretion, cell polarity, and primary cilium formation, results in pancreatitis and neoplasia development in the pancreas, and promotes mutant KRas-driven tumorigenesis.

  • Structural studies on ribosomes of differentially macrolide-resistant <em>Staphylococcus aureus</em> strains
    Research Article
    Open Access
    Structural studies on ribosomes of differentially macrolide-resistant Staphylococcus aureus strains

    André Rivalta, Aliza Fedorenko, Alexandre Le Scornet, Sophie Thompson, Yehuda Halfon, Elinor Breiner Goldstein, Sude Çavdaroglu, Tal Melenitzky, Disha-Gajanan Hiregange, Ella Zimmerman, Anat Bashan, Mee-Ngan Frances Yap, Ada Yonath

    André Rivalta ... Ada Yonath

    Published 9 June 2025

    Macrolide resistance in Staphylococcus aureus is mediated by Erm-family methyltransferases, altering ribosomal drug binding. Using cryo-EM, we analyze solithromycin-bound ribosomes from resistant strains, revealing interactions that may enhance antibiotic efficacy.

View more latest articles
Issue Cover

Current Issue

Volume 8, No. 6
June 2025
  • Table of Contents
  • Cover (PDF)
  • About the Cover
  • Masthead (PDF)
Sign up for alerts
Submit your work
Advertisement
  • Most Read
Loading
  • Message from the new Executive Editor
  • Effective cell cycle synchronization
  • DiPAK senses DPP8/9 activity
  • Senescent macrophages and adipose tissue fibrosis
  • Ocular blood flow reduction promote RGC loss
More...

About Life Science Alliance

Life Science Alliance is an international, open-access, editorially independent, and peer-reviewed journal launched by an alliance of three preeminent scientific organizations: EMBO, The Rockefeller University, and Cold Spring Harbor Laboratory. Life Science Alliance is committed to the rapid, fair, and transparent publication of research papers, resources, and new methods from the full spectrum of life science and biomedical research.

Life Science Alliance LLC is limited liability non-stock corporation jointly owned by Cold Spring Harbor Laboratory, EMBO Press Innovations gGmbH and The Rockefeller University and incorporated in the State of Delaware, USA, with company number 6706208.

More about us

Back to top

EMBO Press LogoRockefeller University Press LogoCold Spring Harbor Logo

Content

  • Home
  • Newest Articles
  • Current Issue
  • Archive
  • Subject Collections

For Authors

  • Submit a Manuscript
  • Author Guidelines
  • License, copyright, Fee

Other Services

  • Alerts
  • Bluesky
  • X/Twitter
  • RSS Feeds

More Information

  • Editors & Staff
  • Reviewer Guidelines
  • Feedback
  • Licensing and Reuse
  • Privacy Policy

ISSN: 2575-1077
© 2025 Life Science Alliance LLC

Life Science Alliance is registered as a trademark in the U.S. Patent and Trade Mark Office and in the European Union Intellectual Property Office.