Newest Articles
Research Article
Temporal and sequential order of nonoverlapping gene networks unraveled in mated female DrosophilaMating triggers successive waves of temporal transcriptomic changes within independent gene networks in female Drosophila, suggesting a recruitment of interconnected modules that vanish in late life.
Research Article
Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagyA detailed look at the properties of a novel USP30 inhibitor applied to studies of mitophagy and pexophagy.
Research Article
TANK prevents IFN-dependent fatal diffuse alveolar hemorrhage by suppressing DNA-cGAS aggregationDiffuse alveolar hemorrhage developed in an SLE mouse model is ameliorated by TANK via the suppression of type I IFN induced by cGAS-mediated sensing of intracellular DNA.
Research Article
Hierarchy of TGFβ/SMAD, Hippo/YAP/TAZ, and Wnt/β-catenin signaling in melanoma phenotype switchingTGFβ, YAP/TAZ, and canonical Wnt/β-catenin signaling functionally interact in a hierarchical manner to induce the switching of melanoma cells from proliferative-to-invasive cell phenotype.
Research Article
TICAM-1/TRIF associates with Act1 and suppresses IL-17 receptor–mediated inflammatory responsesTICAM-1/TRIF, a TLR3 adaptor molecule, associates with Act1 to inhibit the interaction between IL-17RA and Act1, resulting in attenuated IL-17-mediated inflammatory responses.
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Life Science Alliance is an international, open-access, editorially independent, and peer-reviewed journal launched by an alliance of three preeminent scientific organizations: EMBO, Rockefeller University, and Cold Spring Harbor Laboratory. Life Science Alliance is committed to the rapid, fair, and transparent publication of research papers, resources, and new methods from the full spectrum of life science and biomedical research.
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