Newest Articles
Gametic specialization of centromeric histone paralogs in Drosophila virilisSomatic and germline centromeric functions could differ because of different chromatin environments in male and female gametes versus somatic cells. We show that two different centromeric histone paralogs are alternately retained in male versus female gametes in many Drosophila species.
The transcriptional landscape analysis of basal cell carcinomas reveals novel signalling pathways and actionable targetsBasal cell carcinoma (BCC) is the most common skin cancer and human malignancy. By analyzing BCC RNA sequencing data according to clinically important features, we identified novel differentially regulated genes and new targetable pathways. Several biomarkers were validated in patient-derived BCC samples.
Cell-free expression of the outer membrane protein OprF of Pseudomonas aeruginosa for vaccine purposesProduction of recombinant proteoliposomes containing OprF from P. aeruginosa promotes the active open conformation of the porin exposing native epitopes. These OprF proteoliposomes were used as vaccines to protect mice against a P. aeruginosa acute pulmonary infection model.
Urinary prostaglandin E2 as a biomarker for recurrent UTI in postmenopausal womenThis work uses controlled human cohorts to investigate urinary prostaglandin E2, the product of cyclooxygenase-2, as both a diagnostic and prognostic biomarker of recurrent UTI postmenopausal women.
On the relation of gene essentiality to intron structure: a computational and deep learning approachA deep learning classifier predicts gene essentiality by intron sequence. A unique set of intron features of essential genes was found and its importance demonstrated by a high-performing classifier.
Fast but not furious: a streamlined selection method for genome-edited cellsMagnetic-activated genome-edited cell sorting (MAGECS) allows a fast and easy generation of genetically modified cells.
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