Newest Articles
The organizer of chromatin topology RIF1 ensures cellular resilience to DNA replication stressThe conserved protein RIF1 stabilizes replication factories and regulates cohesin recruitment in response to replication stress to limit DNA lesions.
Inflammasome-independent NLRP3 function enforces ATM activity in response to genotoxic stressThis study reports that NLRP3 is down-regulated in cancers and identifies a novel non-immune function for NLRP3 in maintaining genome integrity through the control of ATM activation in response to DSB.
A practical comparison of the next-generation sequencing platform and assemblers using yeast genomeThis research analyzes the general and optimal de novo yeast assembly pipeline using the repetitive yeast genome assembly by benchmarking four different sequencing platforms and seven assembly programs.
Epigenetic signals that direct cell type–specific interferon beta response in mouse cellsPreexisting cell type–specific chromatin features represent an additional regulatory layer for interferon beta response and direct binding of STAT transcription factors and gene induction.
Loss of dyskerin facilitates the acquisition of metastatic traits by altering the mevalonate pathwayCholesterol metabolism may be involved in the early steps of tumor dissemination. Epigenetic regulation of cholesterol synthesis and uptake is of great importance in this process and may constitute a vulnerability of the cancer cell that could be exploited pharmacologically.
Plant mobile domain proteins ensure Microrchidia 1 expression to fulfill transposon silencingThe plant mobile domain proteins MAIN and MAIL1 control the expression of the epigenetic factor Microrchidia 1, which has been involved in transposable element silencing in Arabidopsis.
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