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  • Cell–cell interactions during the formation of primordial follicles in humans
  • Genome-wide profiling of histone modifications in Plasmodium falciparum using CUT&RUN
  • SIRT6 protects RPE from oxidative stress
  • Endothelial cells and IAV infection
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Newest Articles

  • Cost-effective DNA methylation profiling by FML-seq
    Methods
    Open Access
    Cost-effective DNA methylation profiling by FML-seq

    Joseph W Foley, Shirley X Zhu, Robert B West

    Joseph W Foley ... Robert B West

    Published 29 September 2023

    A low-cost, high-throughput method for genome-wide DNA methylation profiling based on methylation-specific restriction digestion and sequencing.

  • TRIM25 targets p300 for degradation
    Research Article
    Open Access
    TRIM25 targets p300 for degradation

    Seham Elabd, Eleonora Pauletto, Valeria Solozobova, Nils Eickhoff, Nuno Padrao, Wilbert Zwart, Christine Blattner

    Seham Elabd ... Christine Blattner

    Published 28 September 2023

    Here, it is shown that the E3 protein TRIM25 targets the transcriptional co-activator p300 in an ubiquitin-independent manner for proteasomal degradation involving the motor protein dynein.

  • KCNQ potassium channels modulate Wnt activity in gastro-oesophageal adenocarcinomas
    Research Article
    Open Access
    KCNQ potassium channels modulate Wnt activity in gastro-oesophageal adenocarcinomas

    David Shorthouse, Lizhe Zhuang, Eric P Rahrmann, Cassandra Kosmidou, Katherine Wickham Rahrmann, Michael Hall, Benedict Greenwood, Ginny Devonshire, Richard J Gilbertson, Rebecca C Fitzgerald, Benjamin A Hall

    David Shorthouse ... Benjamin A Hall

    Published 25 September 2023

    KCNQ3, a potassium channel, is frequently genetically altered in gastro-oesophageal adenocarcinomas and found to be significantly associated with WNT and MYC activity, and cellular proliferation.

  • Comparative analysis of bioinformatics tools to characterize SARS-CoV-2 subgenomic RNAs
    Research Article
    Open Access
    Comparative analysis of bioinformatics tools to characterize SARS-CoV-2 subgenomic RNAs

    Denise Lavezzari, Antonio Mori, Elena Pomari, Michela Deiana, Antonio Fadda, Luca Bertoli, Alessandro Sinigaglia, Silvia Riccetti, Luisa Barzon, Chiara Piubelli, Massimo Delledonne, Maria Rosaria Capobianchi, Concetta Castilletti

    Denise Lavezzari ... Concetta Castilletti

    Published 25 September 2023

    This study compares the performances of three different software in the identification of canonical and noncanonical sgRNAs in amplicon data sequenced with Illumina MiSeq in 250-bp paired ends.

  • Two domains of Tim50 coordinate translocation of proteins across the two mitochondrial membranes
    Research Article
    Open Access
    Two domains of Tim50 coordinate translocation of proteins across the two mitochondrial membranes

    Marcel G Genge, Shalini Roy Chowdhury, Vít Dohnálek, Kaori Yunoki, Takashi Hirashima, Toshiya Endo, Pavel Doležal, Dejana Mokranjac

    Marcel G Genge ... Dejana Mokranjac

    Published 25 September 2023

    Biochemical and genetic experiments identify distinct roles of the two domains of Tim50 in the intermembrane space during translocation of proteins into the mitochondria via the TOM and TIM23 complexes.

  • Themis controls T cell activation, effector functions, and metabolism of peripheral CD8<sup>+</sup> T cells
    Research Article
    Open Access
    Themis controls T cell activation, effector functions, and metabolism of peripheral CD8+ T cells

    Namrata Gautam, Lukasz Wojciech, Jiawei Yap, Yen Leong Chua, Eyan MW Ding, Don CN Sim, Alrina SM Tan, Patricia J Ahl, Mukul Prasad, Desmond WH Tung, John E Connolly, Giulia Adriani, Joanna Brzostek, Nicholas RJ Gascoigne

    Namrata Gautam ... Nicholas RJ Gascoigne

    Published 22 September 2023

    Acute deletion of Themis in peripheral CD8+ T cells shows Themis controls T cell receptor signaling, effector functions, and metabolism. Signal cascade adaptation occurred with chronic Themis deletion.

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About Life Science Alliance

Life Science Alliance is an international, open-access, editorially independent, and peer-reviewed journal launched by an alliance of three preeminent scientific organizations: EMBO, Rockefeller University, and Cold Spring Harbor Laboratory. Life Science Alliance is committed to the rapid, fair, and transparent publication of research papers, resources, and new methods from the full spectrum of life science and biomedical research.

Life Science Alliance LLC is limited liability non-stock corporation jointly owned by Cold Spring Harbor Laboratory, EMBO Press Innovations gGmbH and The Rockefeller University and incorporated in the State of Delaware, USA, with company number 6706208.

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Volume 6, No. 9
September 2023
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