Newest Articles
No evidence that human GIGYF2 interacts with GRB10: implications for human diseaseHuman GRB10 protein, unlike its mouse counterpart, lacks a PPGΦ motif and cannot bind to GIGYF2. These findings question the published literature that links GRB10/GIGYF2 binding to human disease.
hnRNP A1 induces aberrant CFTR exon 9 splicing via a newly discovered ESS elementMissplicing of CFTR exon 9 requires TDP 43 binding to UG-rich sequences upstream of the 3′ss and hnRNP A1 binding to an ESS element in CFTR exon 9.
Transcription arrest induces formation of RNA granules in mitochondriaIn this study, the spatial distribution of mitochondrial-encoded RNAs is investigated and shows that upon transcription arrest, RNAs form granules that show protectivity for transcripts.
The Ragulator complex and lysosomal calcium release are crucial for cell migrationLysosomal calcium efflux via TRPML1 drives leukocyte migration by enhancing Lamtor1–MPRIP interaction, and ouabain improves pathogenic inflammation by disrupting Lamtor1’s lysosomal localization.
RalGAP complexes control secretion and primary cilia in pancreatic diseaseLoss of RalGAP impacts secretion, cell polarity, and primary cilium formation, results in pancreatitis and neoplasia development in the pancreas, and promotes mutant KRas-driven tumorigenesis.
Structural studies on ribosomes of differentially macrolide-resistant Staphylococcus aureus strainsMacrolide resistance in Staphylococcus aureus is mediated by Erm-family methyltransferases, altering ribosomal drug binding. Using cryo-EM, we analyze solithromycin-bound ribosomes from resistant strains, revealing interactions that may enhance antibiotic efficacy.
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