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Physiology

  • Substrate fluxes in brown adipocytes upon adrenergic stimulation and uncoupling protein 1 ablation
    Open Access
    Substrate fluxes in murine brown adipocytes

    Sabine Schweizer, Josef Oeckl, Martin Klingenspor, Tobias Fromme

    Sabine Schweizer ... Tobias Fromme

    Published 14 November 2018

    Quantification of substrate fluxes in brown adipocytes clarifies contributors to extracellular acidification, identifies a futile cycle of lipolysis and re-esterification, and suggests a role for glycogen during activation.

  • Secretory granule protein chromogranin B (CHGB) forms an anion channel in membranes
    Open Access
    Chromogranin B anion channel in membrane

    Gaya P Yadav, Hui Zheng, Qing Yang, Lauren G Douma, Linda B Bloom, Qiu-Xing Jiang

    Gaya P Yadav ... Qiu-Xing Jiang

    Published 24 September 2018

    The CHGB subfamily of secretory granule proteins forms a new family of anion-selective channels by interacting with membranes via two amphipathic α-helices. The channel exhibits higher anion selectivity, larger conductance, higher DIDS-binding affinity, and higher Cl− sensitivity than other known anion channels.

  • Multiple membrane extrusion sites drive megakaryocyte migration into bone marrow blood vessels
    Open Access
    Megakaryocytes migrate by membrane extrusion

    Edward Brown, Leo M Carlin, Claus Nerlov, Cristina Lo Celso, Alastair W Poole

    Edward Brown ... Alastair W Poole

    Published 21 May 2018

    Megakaryocytes enter bone marrow sinusoids to generate platelets by extrusion of internal membrane into the plasma membrane at fusion sites rather than microtubule-driven proplatelet extension.

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