Neuroscience
- Toward an understanding of glucose metabolism in radial glial biology and brain development
We review the literature exploring the role of glycolysis and glucose metabolism in cortical development and discuss recent advances and future directions to better understand metabolic disease and neurodevelopment disorders.
- Regulation of alternative splicing and polyadenylation in neurons
Neurons generate numerous cell-specific isoforms of genes that are expressed more broadly. Here, we review mechanisms that generate neural-specific alternative splicing and 3′UTRs and their biological impacts on the nervous system.
- Nanoscaled RIM clustering at presynaptic active zones revealed by endogenous tagging
This study introduces endogenously epitope-tagged RIM in Drosophila melanogaster and demonstrates its nanoscale reorganization at active zones during homeostatic plasticity using super-resolution localization microscopy.
- Neuroprotective effects of hepatoma-derived growth factor in models of Huntington’s disease
This study demonstrates that hepatoma-derived growth factor improves distinct Huntington’s disease phenotypes in cell culture and genetic mouse models.
- Parenchymal border macrophages regulate tau pathology and tau-mediated neurodegeneration
Parenchymal border macrophages’ (PBMs) function impedes tau pathology and tau-mediated neurodegeneration, whereas tau pathology promotes PBM dysfunction associated with impaired CSF flow.
- IKBKB reduces huntingtin aggregation by phosphorylating serine 13 via a non-canonical IKK pathway
Early exposure of RA induced altered expressions of Wnt-related genes and subsequent osteogenic differentiation in embryonic mouse craniofacial prominences in a spatiotemporal-dependent manner.
- Skewed X-inactivation is associated with retinal dystrophy in female carriers of RPGR mutations
This study shows that skewed X-inactivation modulates the occurrence of Retinitis Pigmentosa in female carriers of RPGR mutations. The findings have implications towards therapeutic interventions.
- Brain IGF-I regulates LTP, spatial memory, and sexual dimorphic behavior
A lack of brain-synthesized IGF-I almost completely abrogates hippocampal long-term potentiation (LTP), alters spatial memory and sex-dependent behavior, and produces major changes in the mouse hippocampal proteome.
- Transcriptome-wide RNA binding analysis of C9orf72 poly(PR) dipeptides
C9orf72 poly(PR) binds to 558 RNAs in human cells, and the sequence GAAGA is enriched at its binding sites. Poly(PR) has nanomolar affinity for GAAGA RNA, and this RNA induces poly(PR) phase separation.
- Peripheral immune system modulates Purkinje cell degeneration in Niemann–Pick disease type C1
We demonstrate that peripheral immune cells are involved in the cerebral neuronal degeneration in Niemann–Pick disease type C1. Our work can contribute to a novel therapeutic strategy that can potentially be combined with the ongoing lipid reduction therapeutic efforts.