The Systemic Control of Growth

  1. Pierre Léopold1,2,3
  1. 1University of Nice-Sophia Antipolis, 06108 Nice, France
  2. 2CNRS, University of Nice-Sophia Antipolis, 06108 Nice, France
  3. 3INSERM, University of Nice-Sophia Antipolis, 06108 Nice, France
  4. 45ICREA, Parc Cientific de Barcelona, 08028 Barcelona, Spain
  1. Correspondence: laura.boulan{at}unice.fr; leopold{at}unice.fr

Abstract

Growth is a complex process that is intimately linked to the developmental program to form adults with proper size and proportions. Genetics is an important determinant of growth, as exemplified by the role of local diffusible molecules setting up organ proportions. In addition, organisms use adaptive responses allowing modulating the size of individuals according to environmental cues, for example, nutrition. Here, we describe some of the physiological principles participating in the determination of final individual size.



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