… Chaugule, who was a member of the original line-up. Also, high up the list are my scientific
mentors, Garry Taylor and Brenda Schulman. I owe Richard Treisman and the London …

Parkin is an E3‐ubiquitin ligase belonging to the RBR (RING–InBetweenRING–RING family),
and is involved in the neurodegenerative disorder Parkinson's disease. Autosomal …

… Given the importance of this domain, and observations that ARJP mutations within this
domain lead to increased ubiquitination activity (Chaugule et al, 2011), we aimed to identify the …

Ubiquitination is a post-translational modification crucial for cellular signaling. A diverse
range of enzymes constitute the machinery that mediates attachment of ubiquitin onto target …

Posttranslational modification of proteins by the small ubiquitin-like modifier (SUMO) is a
potent regulator of various cellular events. Hundreds of substrates have been identified, many …

SUMO chains act as stress-induced degradation tags or repair factor–recruiting signals at
DNA lesions. Although E1 activating, E2 conjugating and E3 ligating enzymes efficiently …

RING-between-RING (RBR) E3 ligases are a class of ubiquitin ligases distinct from RING or
HECT E3 ligases. An important RBR ligase is Parkin, mutations in which lead to early-onset …

Posttranslational modification with the small ubiquitin-related modifier SUMO depends on the
sequential activities of E1, E2, and E3 enzymes. While regulation by E3 ligases and SUMO …

Di‐monoubiquitination of the FANCI‐FANCD2 (ID2) complex is a central and crucial step for
the repair of DNA interstrand crosslinks via the Fanconi anaemia pathway. While FANCD2 …

Repair of DNA damage is critical to genomic integrity and frequently disrupted in cancers.
Ubiquitin-specific protease 1 (USP1), a nucleus-localized deubiquitinase, lies at the interface …