User profiles for V. G. Gorgoulis

Vassilis Gorgoulis

Professor Histology-Embryology, Medical School, National Kapodistrian University of Athens
Verified email at med.uoa.gr
Cited by 32413

Genomic instability—an evolving hallmark of cancer

S Negrini, VG Gorgoulis, TD Halazonetis - Nature reviews Molecular …, 2010 - nature.com
Genomic instability is a characteristic of most cancers. In hereditary cancers, genomic
instability results from mutations in DNA repair genes and drives cancer development, as …

An oncogene-induced DNA damage model for cancer development

TD Halazonetis, VG Gorgoulis, J Bartek - science, 2008 - science.org
Of all types of DNA damage, DNA double-strand breaks (DSBs) pose the greatest challenge
to cells. One might have, therefore, anticipated that a sizable number of DNA DSBs would …

Advances in the biology of oral cancer

…, NG Kastrinakis, AD Tourvas, G Laskaris, VG Gorgoulis - Oral oncology, 2007 - Elsevier
The incidence of oral cancer remains high and is associated with many deaths in both Western
and Asian countries. Several risk factors for the development of oral cancer are now well …

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

VG Gorgoulis, LVF Vassiliou, P Karakaidos… - Nature, 2005 - nature.com
DNA damage checkpoint genes, such as p53, are frequently mutated in human cancer, but
the selective pressure for their inactivation remains elusive 1 , 2 , 3 . We analysed a panel of …

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

…, T Helleday, TD Halazonetis, J Bartek, VG Gorgoulis - Nature, 2006 - nature.com
Recent studies have indicated the existence of tumorigenesis barriers that slow or inhibit
the progression of preneoplastic lesions to neoplasia. One such barrier involves DNA …

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

Y Huyen, O Zgheib, RA DiTullio Jr, VG Gorgoulis… - Nature, 2004 - nature.com
The mechanisms by which eukaryotic cells sense DNA double-strand breaks (DSBs) in order
to initiate checkpoint responses are poorly understood. 53BP1 is a conserved checkpoint …

[HTML][HTML] FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2

…, S Baker, AP Davenport, G Corbett, VG Gorgoulis… - Nature, 2023 - nature.com
Preventing SARS-CoV-2 infection by modulating viral host receptors, such as angiotensin-converting
enzyme 2 (ACE2) 1 , could represent a new chemoprophylactic approach for …

[PDF][PDF] Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer

…, S Itzkowitz, CC Harris, V Rotter, VG Gorgoulis… - Cancer cell, 2013 - cell.com
The tumor suppressor p53 is frequently mutated in human cancer. Common mutant p53 (mutp53)
isoforms can actively promote cancer through gain-of-function (GOF) mechanisms. We …

[HTML][HTML] Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246

…, J Morris, T Forshew, E Appella, VG Gorgoulis… - Nature …, 2018 - nature.com
TP53 mutants (mutp53) are involved in the pathogenesis of most human cancers. Specific
mutp53 proteins gain oncogenic functions (GOFs) distinct from the tumor suppressor activity of …

[HTML][HTML] Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival …

…, D Kletsas, J Bartek, M Serrano, VG Gorgoulis - Aging (Albany …, 2013 - ncbi.nlm.nih.gov
There is shortage of extensive clinicopathologic studies of cellular senescence because the
most reliable senescence biomarker, the detection of Senescence-Associated-beta-…