The role of the androgen receptor (AR) in estrogen receptor (ER)-α-positive breast cancer is
controversial, constraining implementation of AR-directed therapies. Using a diverse, …

Cancers adapt to increasingly potent targeted therapies by reprogramming their phenotype.
Here we investigated such a phenomenon in prostate cancer, in which tumours can escape …

RNA–protein interactions play an important role in numerous cellular processes in health
and disease. In recent years, the global RNA-bound proteome has been extensively studied, …

… RNA was extracted using the AllPrep DNA/RNA universal kit (Qiagen) according to the
manufacturer’s instruction with Qiagen’s QIAcube robot. RNA quantity and quality were assessed …

Deletion of the gene encoding the chromatin remodeler CHD1 is among the most common
alterations in prostate cancer (PCa); however, the tumor-suppressive functions of CHD1 and …

… Collecting the primary tumor(s) as well as the metastases during disease progression and
at time of death is of great interest, enabling the identification of AR cistrome characteristics of …

Androgen receptor (AR) is a key player in prostate cancer development and progression. Here
we applied immunoprecipitation mass spectrometry of endogenous AR in LNCaP cells to …

Fibroblasts are abundantly present in the prostate tumor microenvironment (TME), including
cancer‐associated fibroblasts (CAFs) which play a key role in cancer development. …

… Hierarchical clustering of Stelloo et al's (this manuscript) and Chen et al's data Heatmap of
the correlation between the ChIP-seq data from Stelloo et al and Chen et al based on the 339 …

Understanding how prostate cancers adapt to AR-targeted interventions is critical for identifying
novel drug targets to improve the clinical management of treatment-resistant disease. …