Bariatric surgical procedures, such as vertical sleeve gastrectomy (VSG), are at present the
most effective therapy for the treatment of obesity, and are associated with considerable …

Interactions between the host and gut microbial community likely contribute to Crohn disease
(CD) pathogenesis; however, direct evidence for these interactions at the onset of disease …

Human organoid systems recapitulate in vivo organ architecture yet fail to capture complex
pathologies such as inflammation and fibrosis. Here, using 11 different healthy and diseased …

Molecular mechanisms driving disease course and response to therapy in ulcerative colitis (UC)
are not well understood. Here, we use RNAseq to define pre-treatment rectal gene …

Transdifferentiation is a complete and stable change in cell identity that serves as an
alternative to stem-cell-mediated organ regeneration. In adult mammals, findings of …

Nonalcoholic fatty liver disease (NAFLD), a common prelude to cirrhosis and hepatocellular
carcinoma, is the most common chronic liver disease worldwide. Defining the molecular …

The coevolution of mammalian hosts and their beneficial commensal microbes has led to
development of symbiotic host–microbiota relationships 1 . Epigenetic machinery permits …

Although intestinal homeostasis is maintained by intestinal stem cells (ISCs), regeneration is
impaired upon aging. Here, we first uncover changes in intestinal architecture, cell number, …

Background Lack of evidence-based outcomes data leads to uncertainty in developing treatment
regimens in children who are newly diagnosed with ulcerative colitis. We hypothesised …

Emerging evidence suggests a key contribution to non-alcoholic fatty liver disease (NAFLD)
pathogenesis by Th17 cells. The pathogenic characteristics and mechanisms of hepatic …