… As responder cells, we used splenocytes from FVB/N mice immunized twice with sc
injection of 5 × 10 5 DCs loaded with MHC class I (H2-D q ) restricted rat HER-2/neu–derived …

Metallothionein-directed expression of TGFa in transgenie mice induced a spectrum of changes
in the growth and differentiation of certain adult tissues. First, TGFa promoted a uniform …

To explore the physiological roles of transforming growth factor a (TGFa), we disrupted the
mouse gene by homologous recombination in embryonic stem cells. Homoxygous mutant …

Targeted mice lacking functional EGF or amphiregulin (AR) were derived and bred to the
TGFα-knockout to generate mice lacking various combinations of the three ligands. In contrast …

… et al. 1993; Mann et al. 1993), and expression of a normal-sized TGF-a mRNA was shown
to be significantly reduced in several tissues relative to that in control mice (Luetteke et al. …

Serum proteins from hepatectomized or control rats were separated by gel permeation
chromatography and assayed for stimulation of hepatocyte proliferation in primary cultures of …

Transforming growth factor alpha (TGF alpha) is a 6 kDa polypeptide mitogen that interacts
with the epidermal growth factor receptor and activates its intrinsic tyrosine kinase. The …

… demonstrate that TGFa is not required for early events in chemically mediated hepatocyte
transformation and are consistent both with our own unpublished findings (Dotto P, Luetteke …

To better understand the role of peptide growth factors in sex steroid hormone-mediated
growth of the female reproductive tract, the effect of estrogen on the expression of transforming …

Evidence links chronic inflammation with cancer, but cellular mechanisms involved in this
process remain unclear. We have demonstrated that in humans, inflammatory conditions that …