Clustered regularly interspaced short palindromic repeats-associated protein (CRISPR/Cas9)
system has become a revolutionary tool for gene editing. Since viral delivery systems have …

The Aurora protein kinases are well-established regulators of spindle building and chromosome
segregation in mitotic and meiotic cells. In mouse oocytes, there is significant Aurora …

Cell therapies represent a promising approach to slow down the progression of currently
untreatable neurodegenerative diseases (eg, Alzheimer's and Parkinson's disease or …

Huntington’s disease (HD) is an autosomal dominant disease affecting neurons predominantly
in the striatum due to the production of the toxic huntingtin protein. Lowering the …

Mammalian oocytes are arrested at meiotic prophase I. The dual-specificity phosphatase
CDC25B is essential for cyclin-dependent kinase 1 (CDK1) activation that drives resumption of …

After fertilization, remodeling of the oocyte and sperm genomes is essential to convert these
highly differentiated and transcriptionally quiescent cells into early cleavage‐stage …

RNAi is the sequence-specific mRNA degradation guided by siRNAs produced from long
dsRNA by RNase Dicer. Proteins executing RNAi are present in mammalian cells but rather …

Objective The MATRICS consensus cognitive battery (MCCB) is a widely used neuropsychological
battery for the assessment of cognitive dysfunction in schizophrenia. However, the …

Background: Huntington’s disease (HD) is a devastating neurodegenerative disorder caused
by CAG triplet expansions in the huntingtin gene. Oxidative stress is linked to HD pathology…

Meiotic spindles are critical to ensure proper chromosome segregation during gamete
formation. Oocytes lack centrosomes and use alternative microtubule nucleation pathways for …