Precision medicine is part of the logical evolution of contemporary evidence-based medicine
that seeks to reduce errors and optimize outcomes when making medical decisions and …

A gradual restriction in lineage potential of multipotent stem/progenitor cells is a hallmark of
adult hematopoiesis, but the underlying molecular events governing these processes remain …

Background Precision medicine has the potential to improve cardiovascular disease (CVD)
risk prediction in individuals with Type 2 diabetes (T2D). Methods We conducted a …

In order to fuse lytic granules ( LGs ) with the plasma membrane at the immunological synapse,
cytotoxic T lymphocytes ( CTLs ) have to render these LGs fusion‐competent through the …

Translocations involving the mixed lineage leukemia-1 are recurrent events in acute leukemia
and associate with lymphoid (ALL), myeloid (AML) or mixed lineage (MLL) subtypes. …

Maf transcription factors are critical regulators of beta-cell function. We have previously
shown that reduced MafA expression in human and mouse islets is associated with a pro-…

Although it is firmly established that endogenous immunity can prevent cancer outgrowth,
with a range of immunomodulatory strategies reaching clinical use, most studies on the topic …

… Der spezifische Antikörper wurde mit 20 ml 100 mM Glyzin pH 2,7 eluiert, wobei das Eluat
in 2 ml 1 M Tris-HCl pH 8,0 rührend aufgefangen wurde. Es erfolgte ein Waschschritt mit 10 …

In order to fuse lytic granules (LGs) with the plasma membrane at the immunological synapse,
cytotoxic T lymphocytes (CTLs) have to render these LGs fusion-competent through the …

Background: Cardiac β-adrenergic receptors (β-ARs) couple to the stimulatory G-protein (G
s ), activating adenylyl cyclase to produce cAMP and increase force of contraction. Animal …