Although many of the advances in hepatic surgery have been linked to improvements in
technology, there is no denying the impact of thorough knowledge of the internal anatomy of the …

Matrix metalloproteinases (MMPs) have received much attention in recent years for their role
in a variety of malignancies. Pancreatic cancer is no exception; MMP-2 and MMP-9 show …

Working knowledge of extrahepatic biliary anatomy is of paramount importance to the
general surgeon. The laparoscopic cholecystectomy is one of the most common surgical …

ContextWhile global microRNA (miRNA) expression patterns of many embryologic, physiologic,
and oncogenic processes have been described, description of the role of miRNAs in …

Oncolytic viruses and active immunotherapeutics have complementary mechanisms of action
(MOA) that are both self amplifying in tumors, yet the impact of dose on subject outcome is …

Background MicroRNAs are small (18–22 nucleotides) noncoding RNAs involved in
posttranscriptional modification of many target genes. One of these, microRNA-21 (miR-21), has …

We studied miRNA profiles in 4419 human samples (3312 neoplastic, 1107 nonmalignant),
corresponding to 50 normal tissues and 51 cancer types. The complexity of our database …

Objective Limited efficacy of immune checkpoint inhibitors in pancreatic ductal adenocarcinoma
(PDAC) has prompted investigation into combination therapy. We hypothesised that …

… M. Bloomston). The project described was supported by Award Number UL1RR025755
from the National Center for Research Resources, funded by the Office of the Director, NIH (OD), …

Objective: To test by randomized prospective multicenter trial the hypothesis that
pancreaticoduodenectomy (PD) without the use of intraperitoneal drainage does not increase the …