When the food intake of organisms such as yeast and rodents is reduced (dietary restriction),
they live longer than organisms fed a normal diet. A similar effect is seen when the activity …

Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …

Aging is driven by hallmarks fulfilling the following three premises: (1) their age-associated
manifestation, (2) the acceleration of aging by experimentally accentuating them, and (3) the …

Background Increased understanding of whether individuals who have recovered from
COVID-19 are protected from future SARS-CoV-2 infection is an urgent requirement. We aimed to …

The Drosophila melanogaster gene chicoencodes an insulin receptor substrate that
functions in an insulin/insulin-like growth factor (IGF) signaling pathway. In the nematode …

FEMALE Drosophila melanogaster with environmentally 1–3 or genetically 4 elevated rates
of mating die younger than controls. This cost of mating is not attributable to receipt of sperm …

Caloric restriction (CR) protects against aging and disease, but the mechanisms by which
this affects mammalian life span are unclear. We show in mice that deletion of ribosomal S6 …

Autophagy is a fundamental cellular process that eliminates molecules and subcellular
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …

Reduced food intake, avoiding malnutrition, can ameliorate aging and aging-associated
diseases in invertebrate model organisms, rodents, primates, and humans. Recent findings …

Age is the main risk factor for the prevalent diseases of developed countries: cancer,
cardiovascular disease and neurodegeneration. The ageing process is deleterious for fitness, but …