MBNL proteins and their target RNAs, interaction and splicing regulation
…, E Stepniak-Konieczna, K Sobczak - Nucleic acids …, 2014 - academic.oup.com
Muscleblind-like (MBNL) proteins are key regulators of precursor and mature mRNA
metabolism in mammals. Based on published and novel data, we explore models of tissue-specific …
metabolism in mammals. Based on published and novel data, we explore models of tissue-specific …
Triplet repeat RNA structure and its role as pathogenic agent and therapeutic target
WJ Krzyzosiak, K Sobczak… - Nucleic acids …, 2012 - academic.oup.com
This review presents detailed information about the structure of triplet repeat RNA and
addresses the simple sequence repeats of normal and expanded lengths in the context of the …
addresses the simple sequence repeats of normal and expanded lengths in the context of the …
Reversal of RNA dominance by displacement of protein sequestered on triplet repeat RNA
TM Wheeler, K Sobczak, JD Lueck, RJ Osborne, X Lin… - Science, 2009 - science.org
Genomic expansions of simple tandem repeats can give rise to toxic RNAs that contain
expanded repeats. In myotonic dystrophy, the expression of expanded CUG repeats (CUG exp ) …
expanded repeats. In myotonic dystrophy, the expression of expanded CUG repeats (CUG exp ) …
Numerical investigation of conventional and modified Savonius wind turbines
K Kacprzak, G Liskiewicz, K Sobczak - Renewable energy, 2013 - Elsevier
The performance of a Savonius wind turbine with constant cross-sections is examined by
means of quasi 2D flow predictions executed in ANSYS CFX. Simulations were performed in a …
means of quasi 2D flow predictions executed in ANSYS CFX. Simulations were performed in a …
[PDF][PDF] Loss of MBNL leads to disruption of developmentally regulated alternative polyadenylation in RNA-mediated disease
…, M Li, DJ Finn, M Goodwin, C Zhang, K Sobczak… - Molecular cell, 2014 - cell.com
Inhibition of muscleblind-like (MBNL) activity due to sequestration by microsatellite expansion
RNAs is a major pathogenic event in the RNA-mediated disease myotonic dystrophy (DM). …
RNAs is a major pathogenic event in the RNA-mediated disease myotonic dystrophy (DM). …
[HTML][HTML] Structural features of microRNA (miRNA) precursors and their relevance to miRNA biogenesis and small interfering RNA/short hairpin RNA design
J Krol, K Sobczak, U Wilczynska, M Drath… - Journal of Biological …, 2004 - ASBMB
We have established the structures of 10 human microRNA (miRNA) precursors using
biochemical methods. Eight of these structures turned out to be different from those that were …
biochemical methods. Eight of these structures turned out to be different from those that were …
[HTML][HTML] Development of green storable hybrid rocket propulsion technology using 98% hydrogen peroxide as oxidizer
… Kamil Sobczak … A PXI setup with in-house LabVIEW software by Sobczak and Mayer was
used. … Lund, G.; Starrett, W.; Jensen, K. Development and lab-scale testing of a gas generator …
used. … Lund, G.; Starrett, W.; Jensen, K. Development and lab-scale testing of a gas generator …
Splicing biomarkers of disease severity in myotonic dystrophy
M Nakamori, K Sobczak, A Puwanant… - Annals of …, 2013 - Wiley Online Library
Objective To develop RNA splicing biomarkers of disease severity and therapeutic response
in myotonic dystrophy type 1 (DM1) and type 2 (DM2). Methods In a discovery cohort, we …
in myotonic dystrophy type 1 (DM1) and type 2 (DM2). Methods In a discovery cohort, we …
Muscleblind-like 1 interacts with RNA hairpins in splicing target and pathogenic RNAs
Y Yuan, SA Compton, K Sobczak… - Nucleic acids …, 2007 - academic.oup.com
The MBNL and CELF proteins act antagonistically to control the alternative splicing of
specific exons during mammalian postnatal development. This process is dysregulated in …
specific exons during mammalian postnatal development. This process is dysregulated in …
RNA structure of trinucleotide repeats associated with human neurological diseases
K Sobczak, M de Mezer, G Michlewski… - Nucleic acids …, 2003 - academic.oup.com
The tandem repeats of trinucleotide sequences are present in many human genes and their
expansion in specific genes causes a number of hereditary neurological disorders. The …
expansion in specific genes causes a number of hereditary neurological disorders. The …