A driving force of the cell cycle is the activation of cyclin-dependent kinases (CDKs), the
activities of which are controlled by the ubiquitin-mediated proteolysis of key regulators such as …

Regulation of the cell cycle is dependent on protein degradation by the ubiquitin–proteasome
system. Two major ubiquitin ligases, the anaphase-promoting complex or cyclosome (APC/…

The transition from G 1 phase to S phase of the mammalian cell cycle is controlled by many
positive and negative regulators, among which cyclin E and p27 Kip1 , respectively, undergo …

Hematopoietic stem cells (HSCs) are maintained in an undifferentiated quiescent state within
a bone marrow niche. Here we show that Foxo3a, a forkhead transcription factor that acts …

The F‐box protein Skp2 mediates c‐Myc ubiquitylation by binding to the MB2 domain.
However, the turnover of c‐Myc is largely dependent on phosphorylation of threonine‐58 and …

The U box is a domain of ∼70 amino acids that is present in proteins from yeast to humans.
The prototype U box protein, yeast Ufd2, was identified as a ubiquitin chain assembly factor …

The effective use of targeted therapy is highly dependent on the identification of responder
patient populations. Loss of FBW7, which encodes a tumour-suppressor protein, is frequently …

The p16 INK4a cyclin-dependent kinase inhibitor has a key role in establishing stable G1
cell-cycle arrest through activating the retinoblastoma (Rb) tumour suppressor protein pRb 1 , …

The transcription regulatory oncoprotein c-Myc controls genes involved in cell growth,
apoptosis, and oncogenesis. c-Myc is turned over very quickly through the ubiquitin/proteasome …

Protein kinase C (PKC), which comprises 11 closely related isoforms, has been implicated
in a wide variety of cellular processes, such as growth, differentiation, secretion, apoptosis …