Background Transthyretin amyloidosis, also called ATTR amyloidosis, is associated with
accumulation of ATTR amyloid deposits in the heart and commonly manifests as progressive …

Physical activity protects against cardiovascular disease, and physiological cardiac hypertrophy
associated with regular exercise is usually beneficial, in marked contrast to pathological …

Congenital diaphragmatic hernia (CDH) is a severe birth defect that is accompanied by
malformations of the lung, heart, testis, and other organs. Patients with CDH may have any …

Myosin II mutant Dictyostelium amoebae crawl more slowly than wild-type cells. Thus, myosin
II must contribute to amoeboid locomotion. We propose that contractile forces generated …

… J. Barhanin kindly provided the minK in situ probe. This work is supported by grants from
the NIH (to PY Jay, RG Gourdie, and S. Izumo), the Marram and Carpenter Fund for Innovation …

Twenty years ago, chromosomal abnormalities were the only identifiable genetic causes of
a small fraction of congenital heart defects (CHD). Today, a de novo or inherited genetic …

Study of monogenic congenital heart disease (CHD) has provided entry points to gain new
understanding of heart development and the molecular pathogenesis of CHD. In this review, …

Congenital diaphragmatic hernia (CDH) is an often fatal birth defect that is commonly associated
with pulmonary hypoplasia and cardiac malformations. Some investigators hypothesize …

BACKGROUND: Conditional gene inactivation in mice using the bacteriophage P1 Cre-loxP
recombination system requires transgenic expression of Cre-recombinase driven by a tissue…

Actin assembly is important for cell motility, but the mechanism of assembly and how it relates
to motility in vivo is largely unknown. In vitro, actin assembly can be controlled by proteins, …