Comprehensive genomic profiles of small cell lung cancer

…, B Pinther, P Schaub, C Becker, J Altmüller, J Yokota… - Nature, 2015 - nature.com
We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest
human cancers. In nearly all the tumours analysed we found bi-allelic inactivation of TP53 …

[HTML][HTML] Swarm learning for decentralized and confidential clinical machine learning

…, C Lehmann, M Augustin, J Rybniker, J Altmüller… - Nature, 2021 - nature.com
Fast and reliable detection of patients with severe and heterogeneous illnesses is a major
goal of precision medicine 1 , 2 . Patients with leukaemia can be identified using machine …

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

…, C Müller, V Di Cerbo, HU Schildhaus, J Altmüller… - Nature …, 2012 - nature.com
Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor prognosis 1 ,
2 , 3 . We sequenced 29 SCLC exomes, 2 genomes and 15 transcriptomes and found an …

Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer

…, S Ansén, D Rauh, I Baessmann, J Altmüller… - Science translational …, 2010 - science.org
Lung cancer remains one of the leading causes of cancer-related death in developed countries.
Although lung adenocarcinomas with EGFR mutations or EML4-ALK fusions respond to …

[HTML][HTML] Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses

…, U Damm, EA Buiate, L Epstein, N Alkan, J Altmüller… - Nature …, 2012 - nature.com
Colletotrichum species are fungal pathogens that devastate crop plants worldwide. Host
infection involves the differentiation of specialized cell types that are associated with penetration…

[PDF][PDF] Genomewide scans of complex human diseases: true linkage is hard to find

J Altmüller, LJ Palmer, G Fischer, H Scherb… - The American Journal of …, 2001 - cell.com
Many "complex" human diseases, which involve multiple genetic and environmental determinants,
have increased in incidence during the past 2 decades. During the same time period, …

Telomerase activation by genomic rearrangements in high-risk neuroblastoma

…, W Vogel, J Altmüller, P Nürnberg, J Thierry-Mieg… - Nature, 2015 - nature.com
Neuroblastoma is a malignant paediatric tumour of the sympathetic nervous system 1 . Roughly
half of these tumours regress spontaneously or are cured by limited therapy. By contrast, …

Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes

…, RJ Harvey, P Hoffmann, S Herms, J Altmueller… - Nature …, 2013 - nature.com
Idiopathic focal epilepsy (IFE) with rolandic spikes is the most common childhood epilepsy,
comprising a phenotypic spectrum from rolandic epilepsy (also benign epilepsy with …

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

…, KC Barnes, WOC Cookson, J Altmüller… - Nature …, 2018 - nature.com
We examined common variation in asthma risk by conducting a meta-analysis of worldwide
asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of …

Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome

…, W Ji, JD Overton, SM Mane, G Nürnberg, J Altmüller… - Nature …, 2013 - nature.com
Pathologic thrombosis is a major cause of mortality. Hemolytic-uremic syndrome (HUS)
features episodes of small-vessel thrombosis resulting in microangiopathic hemolytic anemia, …