Comprehensive genomic profiles of small cell lung cancer
…, B Pinther, P Schaub, C Becker, J Altmüller, J Yokota… - Nature, 2015 - nature.com
We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest
human cancers. In nearly all the tumours analysed we found bi-allelic inactivation of TP53 …
human cancers. In nearly all the tumours analysed we found bi-allelic inactivation of TP53 …
[HTML][HTML] Swarm learning for decentralized and confidential clinical machine learning
…, C Lehmann, M Augustin, J Rybniker, J Altmüller… - Nature, 2021 - nature.com
Fast and reliable detection of patients with severe and heterogeneous illnesses is a major
goal of precision medicine 1 , 2 . Patients with leukaemia can be identified using machine …
goal of precision medicine 1 , 2 . Patients with leukaemia can be identified using machine …
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
…, C Müller, V Di Cerbo, HU Schildhaus, J Altmüller… - Nature …, 2012 - nature.com
Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor prognosis 1 ,
2 , 3 . We sequenced 29 SCLC exomes, 2 genomes and 15 transcriptomes and found an …
2 , 3 . We sequenced 29 SCLC exomes, 2 genomes and 15 transcriptomes and found an …
Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer
…, S Ansén, D Rauh, I Baessmann, J Altmüller… - Science translational …, 2010 - science.org
Lung cancer remains one of the leading causes of cancer-related death in developed countries.
Although lung adenocarcinomas with EGFR mutations or EML4-ALK fusions respond to …
Although lung adenocarcinomas with EGFR mutations or EML4-ALK fusions respond to …
[HTML][HTML] Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses
Colletotrichum species are fungal pathogens that devastate crop plants worldwide. Host
infection involves the differentiation of specialized cell types that are associated with penetration…
infection involves the differentiation of specialized cell types that are associated with penetration…
[PDF][PDF] Genomewide scans of complex human diseases: true linkage is hard to find
J Altmüller, LJ Palmer, G Fischer, H Scherb… - The American Journal of …, 2001 - cell.com
Many "complex" human diseases, which involve multiple genetic and environmental determinants,
have increased in incidence during the past 2 decades. During the same time period, …
have increased in incidence during the past 2 decades. During the same time period, …
Telomerase activation by genomic rearrangements in high-risk neuroblastoma
…, W Vogel, J Altmüller, P Nürnberg, J Thierry-Mieg… - Nature, 2015 - nature.com
Neuroblastoma is a malignant paediatric tumour of the sympathetic nervous system 1 . Roughly
half of these tumours regress spontaneously or are cured by limited therapy. By contrast, …
half of these tumours regress spontaneously or are cured by limited therapy. By contrast, …
Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes
Idiopathic focal epilepsy (IFE) with rolandic spikes is the most common childhood epilepsy,
comprising a phenotypic spectrum from rolandic epilepsy (also benign epilepsy with …
comprising a phenotypic spectrum from rolandic epilepsy (also benign epilepsy with …
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks
…, KC Barnes, WOC Cookson, J Altmüller… - Nature …, 2018 - nature.com
We examined common variation in asthma risk by conducting a meta-analysis of worldwide
asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of …
asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of …
Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome
…, W Ji, JD Overton, SM Mane, G Nürnberg, J Altmüller… - Nature …, 2013 - nature.com
Pathologic thrombosis is a major cause of mortality. Hemolytic-uremic syndrome (HUS)
features episodes of small-vessel thrombosis resulting in microangiopathic hemolytic anemia, …
features episodes of small-vessel thrombosis resulting in microangiopathic hemolytic anemia, …