T lymphocytes reactive with the product of the Mls a -allele of the minor lymphocyte stimulating
(Mls) locus use a predominant T-cell receptor β-chain variable gene segment (V β6 ). …

The class II transactivator (CIITA) has been referred to as the "master control factor" for the
expression of MHC class II (MHCII) genes. As our knowledge on the specificity and function of …

Superantigens (SAgs) are proteins of microbial origin that bind to major his tocompatibility
complex (MHC) class II molecules and stimulate T cells via interaction with the V f3 domain of …

Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses,
including cell growth, differentiation, and even death. Here we describe a novel member of …

Class II major histocompatibility (MHC) molecules have an immunoregulatory role. These
cell-surface glycoproteins present fragments of protein antigens (or peptides) to thymus-…

… T cell clones derived from six different PLN (H-2”) or (PL/J x SJL) Fl (H-2Uxs) mice revealed a
… The hybrid was digested with RNAase H (Bethesda Research Laboratories) … Acha-Orbea …

Interleukin 7 is essential for the survival of naive T lymphocytes. Despite its importance, its
cellular source in the periphery remains poorly defined. Here we report a critical function for …

… H-2kbds, but with this panel of monoclonal antibodies it was not possible to discriminate
NOD from I-Auf. Monoclonal antibody BP107 did not recognize H-… the NOD and the H-2d I-A1 …

… H 1)/T H 2 phenotype; and elevated cytotoxic T cell activity (7–10). In addition to parasite-derived
virulence factors, host genetics [such as polymorphisms for TNF-α and interleukin-6 (IL-…

New-variant Creutzfeldt–Jakob disease and scrapie are typically initiated by extracerebral
exposure to the causative agent, and exhibit early prion replication in lymphoid organs 1, 2. In …