CD26/DPP4-a potential biomarker and target for cancer therapy

N Enz, G Vliegen, I De Meester… - Pharmacology & …, 2019 - Elsevier
CD26/dipeptidyl peptidase (DPP)4 is a membrane-bound protein found in many cell types
of the body, and a soluble form is present in body fluids. There is longstanding evidence that …

[HTML][HTML] The expression of proline-specific enzymes in the human lung

G Vliegen, TK Raju, D Adriaensen… - Annals of …, 2017 - ncbi.nlm.nih.gov
The pathophysiology of lung diseases is very complex and proteolytic enzymes may play a
role or could be used as biomarkers. In this review, the literature was searched to make an …

[HTML][HTML] Targeting fibroblast activation protein (FAP): next generation PET radiotracers using squaramide coupled bifunctional DOTA and DATA5m chelators

ES Moon, F Elvas, G Vliegen, S De Lombaerde… - EJNMMI radiopharmacy …, 2020 - Springer
… Ex vivo biodistribution showed highest uptake in tumor (5.2%ID/g) at 60 min post injection
… with high with an overall uptake of 5.2%ID/g. In general, the tumor-to-organ ratios are high …

DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages

NM de Vasconcelos, G Vliegen… - Life science …, 2019 - life-science-alliance.org
… ) B6 Nlrp1b+ or B6 Nlrp1b+ ASC −/− BMDMs were treated with 10 μM of VBP (E, G) or
1G244 (F, G) for 8 h. Combined cell lysate and supernatant samples were immunoblotted for …

CD26 costimulatory blockade improves lung allograft rejection and is associated with enhanced interleukin-10 expression

…, JH Jang, I De Meester, L Baerts, G Vliegen… - The Journal of Heart and …, 2016 - Elsevier
Background The ectoenzyme CD26/dipeptidyl peptidase 4 (DPP4) has costimulatory
activity that contributes to T cell activation and proliferation. Here, we aimed to target this …

Novel small molecule-derived, highly selective substrates for fibroblast activation protein (FAP)

A De Decker, G Vliegen, D Van Rompaey… - ACS Medicinal …, 2019 - ACS Publications
Fibroblast activation protein (FAP) is a proline-selective serine protease. It is hardly expressed
in healthy adult tissue but upregulated in tissue remodeling sites associated with several …

Vildagliptin‐Derived Dipeptidyl Peptidase 9 (DPP9) Inhibitors: Identification of a DPP8/9‐Specific Lead

…, O Beyens, Y Van Rymenant, G Vliegen… - …, 2022 - Wiley Online Library
g., the DPP9/4 selectivity indices for 5 d–o that are >1). Nonetheless, the DPP9/8 selectivity
… The azido-cyanopyrrolidines 5 d–g take a special position in this subseries. These …

The dipeptidyl peptidases 4, 8, and 9 in mouse monocytes and macrophages: DPP8/9 inhibition attenuates M1 macrophage activation in mice

Y Waumans, G Vliegen, L Maes, M Rombouts… - Inflammation, 2016 - Springer
Atherosclerosis remains the leading cause of death in Western countries. Dipeptidyl peptidase
(DPP) 4 has emerged as a novel target for the prevention and treatment of atherosclerosis…

Auto-ignition hazard of mixtures of ammonia, hydrogen, methane and air in a urea plant

…, A Van den Aarssen, H Winter, G Vliegen… - Journal of hazardous …, 2002 - Elsevier
The auto-ignition of NH 3 /CH 4 /H 2 /air mixtures constitutes a hazard that is of much concern
in urea plants. In this study, the auto-ignition behaviour of NH 3 /CH 4 /H 2 /air mixtures is …

[HTML][HTML] Anti-inflammatory effects on ischemia/reperfusion-injured lung transplants by the cluster of differentiation 26/dipeptidylpeptidase 4 (CD26/DPP4) inhibitor …

…, F Janker, I De Meester, L Baerts, G Vliegen… - The Journal of thoracic …, 2017 - Elsevier
Objectives We showed previously that stromal cell−derived factor 1 (SDF-1) is a substrate of
cluster of differentiation 26/dipeptidylpeptidase 4 (CD26/DPP4) and exerts regenerative …