User profiles for G. B. Lesinski

gregory lesinski

Emory University
Verified email at emory.edu
Cited by 7888

[HTML][HTML] Immune checkpoint inhibitors for the treatment of MSI-H/MMR-D colorectal cancer and a perspective on resistance mechanisms

…, M Akce, O Alese, W Shaib, GB Lesinski… - British journal of …, 2019 - nature.com
Metastatic colorectal cancer (CRC) with a mismatch repair-deficiency (MMR-D)/microsatellite
instability-high (MSI-H) phenotype carries unique characteristics such as increased tumour …

Novel vaccine strategies to T-independent antigens

GB Lesinski, MAJ Westerink - Journal of microbiological methods, 2001 - Elsevier
T cell independent antigens do not require T cell help to induce an immune response, and
are characterized by a lack of immunologic memory. These antigens can be divided into two …

[HTML][HTML] The potential of CAR T cell therapy in pancreatic cancer

M Akce, MY Zaidi, GB Lesinski - Frontiers in immunology, 2018 - frontiersin.org
Pancreatic cancer has a dismal prognosis and effective treatment options are limited. It is
projected to be the second most common cause of cancer related mortality in the United States …

IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer

…, T Ludwig, M Bloomston, T Bekaii-Saab, GB Lesinski - Gut, 2018 - gut.bmj.com
Objective Limited efficacy of immune checkpoint inhibitors in pancreatic ductal adenocarcinoma
(PDAC) has prompted investigation into combination therapy. We hypothesised that …

Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner

…, WL Frankel, T Bekaii-Saab, M Bloomston, GB Lesinski - Cancer research, 2013 - AACR
… This work was supported by NIH Grants 5T32CA009338-34 (TA Mace), K22CA134551 (GB
Lesinski), The Valvano Foundation for Cancer Research (GB Lesinski), P30CA016058-36 (…

β-Blockers and survival among Danish patients with malignant melanoma: a population-based cohort study

…, EV Yang, S Antonsen, AH Riis, GB Lesinski… - … , biomarkers & prevention, 2011 - AACR
Background: To study whether use of β-blockers increases survival in patients with malignant
melanoma because experimental data suggest that catecholamine hormones may be …

Enhanced bioavailability of lycopene when consumed as cis‐isomers from tangerine compared to red tomato juice, a randomized, cross‐over clinical trial

…, CD Timmers, DM Francis, GB Lesinski… - Molecular nutrition & …, 2015 - Wiley Online Library
Scope Tangerine tomatoes (Solanum lycopersicum) are rich in tetra‐cis‐lycopene resulting
from natural variation in carotenoid isomerase. Our objective was to compare the …

Myeloid-derived suppressor cell inhibition of the IFN response in tumor-bearing mice

BL Mundy-Bosse, GB Lesinski, AC Jaime-Ramirez… - Cancer research, 2011 - AACR
Our group and others have determined that immune effector cells from patients with advanced
cancers exhibit reduced activation of IFN signaling pathways. We hypothesized that …

[HTML][HTML] Multicenter randomized phase II trial of atezolizumab with or without cobimetinib in biliary tract cancers

…, HX Chen, E Sharon, GB Lesinski… - The Journal of …, 2021 - Am Soc Clin Investig
BACKGROUND MEK inhibitors have limited activity in biliary tract cancers (BTCs) as
monotherapy but are hypothesized to enhance responses to programmed death ligand 1 (PD-L1) …

[HTML][HTML] Randomized phase 2 trial of the oncolytic virus pelareorep (Reolysin) in upfront treatment of metastatic pancreatic adenocarcinoma

…, B El-Rayes, CD Timmers, J Zwiebel, GB Lesinski… - Molecular Therapy, 2016 - cell.com
Pelareorep causes oncolysis in tumor cells with activated Ras. We hypothesized that
pelareorep would have efficacy and immunomodulatory activity in metastatic pancreatic …