User profiles for F. Grebien
Florian GrebienInstitute for Medical Biochemistry - University of Veterinary Medicine Vienna Verified email at vetmeduni.ac.at Cited by 4466 |
JAK-STAT signaling in cancer: From cytokines to non-coding genome
In the past decades, studies of the Janus kinases (JAKs) and signal transducers and activators
of transcription (STATs) signaling have uncovered highly conserved programs linking …
of transcription (STATs) signaling have uncovered highly conserved programs linking …
The growing arsenal of ATP-competitive and allosteric inhibitors of BCR–ABL
… To target the SH2-kinase domain interface in BCR–ABL, Grebien and colleagues (47) sought
to generate a monobody protein that would bind to the SH2 domain with very high affinity …
to generate a monobody protein that would bind to the SH2 domain with very high affinity …
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia
… (f) qRT-PCR analysis of Wdr5 expression in wild-type fetal liver cells transduced with the
indicated shRNA constructs. Data throughout are presented as mean ± sd of triplicate …
indicated shRNA constructs. Data throughout are presented as mean ± sd of triplicate …
[HTML][HTML] Roles of SETD2 in leukemia—transcription, DNA-damage, and beyond
… The Grebien laboratory has received funding from the European Research Council under
the European Union’s Horizon 2020 research and innovation program (grant agreement n …
the European Union’s Horizon 2020 research and innovation program (grant agreement n …
Stat5 is indispensable for the maintenance of bcr/abl‐positive leukaemia
…, MA Hoelzl, S Fajmann, F Grebien… - EMBO molecular …, 2010 - embopress.org
… Deletion of Stat5 induces a cell cycle arrest (F) and apoptosis (H), while deletion of Stat3
has no significant effect on evaluated parameters (E, G). Numbers show percentages of cells in …
has no significant effect on evaluated parameters (E, G). Numbers show percentages of cells in …
CD14 is a coreceptor of Toll-like receptors 7 and 9
Recognition of pathogens by the innate immune system requires proteins that detect conserved
molecular patterns. Nucleic acids are recognized by cytoplasmic sensors as well as by …
molecular patterns. Nucleic acids are recognized by cytoplasmic sensors as well as by …
BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia
…, W Warsch, E Eckelhart, I Kaupe, F Grebien… - Nature chemical …, 2012 - nature.com
… (f) Ku812 cells were treated for 72 h with indicated JAK2 TKIs. FACS blots, apoptotic stages
of cells measured via annexin V–propidium iodide staining. Top, IC 50 values of applied …
of cells measured via annexin V–propidium iodide staining. Top, IC 50 values of applied …
[HTML][HTML] STAT3 regulated ARF expression suppresses prostate cancer metastasis
…, M Herac, OH Krämer, P Mazal, F Grebien… - Nature …, 2015 - nature.com
… (f,g) Bar graphs indicate percentage of cells positive for Ki-67 and CC3 (e). Protein levels
quantification was done with HistoQuest software (n=5). Data from c, f and g were analysed by …
quantification was done with HistoQuest software (n=5). Data from c, f and g were analysed by …
[HTML][HTML] Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation
The SH2 domain of cytoplasmic tyrosine kinases can enhance catalytic activity and substrate
recognition, but the molecular mechanisms by which this is achieved are poorly understood…
recognition, but the molecular mechanisms by which this is achieved are poorly understood…
A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain
J Wojcik, O Hantschel, F Grebien, I Kaupe… - Nature structural & …, 2010 - nature.com
Interactions between Src homology 2 (SH2) domains and phosphotyrosine sites regulate
tyrosine kinase signaling networks. Selective perturbation of these interactions is challenging …
tyrosine kinase signaling networks. Selective perturbation of these interactions is challenging …