User profiles for F. Grebien

Florian Grebien

Institute for Medical Biochemistry - University of Veterinary Medicine Vienna
Verified email at vetmeduni.ac.at
Cited by 4466

JAK-STAT signaling in cancer: From cytokines to non-coding genome

…, M Schlederer, Z Culig, O Merkel, R Moriggl, F Grebien… - Cytokine, 2016 - Elsevier
In the past decades, studies of the Janus kinases (JAKs) and signal transducers and activators
of transcription (STATs) signaling have uncovered highly conserved programs linking …

The growing arsenal of ATP-competitive and allosteric inhibitors of BCR–ABL

O Hantschel, F Grebien, G Superti-Furga - Cancer research, 2012 - AACR
… To target the SH2-kinase domain interface in BCR–ABL, Grebien and colleagues (47) sought
to generate a monobody protein that would bind to the SH2 domain with very high affinity …

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

F Grebien, M Vedadi, M Getlik, R Giambruno… - Nature chemical …, 2015 - nature.com
… (f) qRT-PCR analysis of Wdr5 expression in wild-type fetal liver cells transduced with the
indicated shRNA constructs. Data throughout are presented as mean ± sd of triplicate …

[HTML][HTML] Roles of SETD2 in leukemia—transcription, DNA-damage, and beyond

A Skucha, J Ebner, F Grebien - International journal of molecular sciences, 2019 - mdpi.com
… The Grebien laboratory has received funding from the European Research Council under
the European Union’s Horizon 2020 research and innovation program (grant agreement n …

Stat5 is indispensable for the maintenance of bcr/abl‐positive leukaemia

…, MA Hoelzl, S Fajmann, F Grebien… - EMBO molecular …, 2010 - embopress.org
… Deletion of Stat5 induces a cell cycle arrest (F) and apoptosis (H), while deletion of Stat3
has no significant effect on evaluated parameters (E, G). Numbers show percentages of cells in …

CD14 is a coreceptor of Toll-like receptors 7 and 9

…, O Sharif, A Pichlmair, S Blüml, F Grebien… - Journal of Experimental …, 2010 - rupress.org
Recognition of pathogens by the innate immune system requires proteins that detect conserved
molecular patterns. Nucleic acids are recognized by cytoplasmic sensors as well as by …

BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia

…, W Warsch, E Eckelhart, I Kaupe, F Grebien… - Nature chemical …, 2012 - nature.com
… (f) Ku812 cells were treated for 72 h with indicated JAK2 TKIs. FACS blots, apoptotic stages
of cells measured via annexin V–propidium iodide staining. Top, IC 50 values of applied …

[HTML][HTML] STAT3 regulated ARF expression suppresses prostate cancer metastasis

…, M Herac, OH Krämer, P Mazal, F Grebien… - Nature …, 2015 - nature.com
… (f,g) Bar graphs indicate percentage of cells positive for Ki-67 and CC3 (e). Protein levels
quantification was done with HistoQuest software (n=5). Data from c, f and g were analysed by …

[HTML][HTML] Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation

…, M Kofler, O Hantschel, GD Gish, F Grebien… - Cell, 2008 - cell.com
The SH2 domain of cytoplasmic tyrosine kinases can enhance catalytic activity and substrate
recognition, but the molecular mechanisms by which this is achieved are poorly understood…

A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain

J Wojcik, O Hantschel, F Grebien, I Kaupe… - Nature structural & …, 2010 - nature.com
Interactions between Src homology 2 (SH2) domains and phosphotyrosine sites regulate
tyrosine kinase signaling networks. Selective perturbation of these interactions is challenging …