User profiles for E. Martinez-Salas

Encarnacion Martinez-Salas

Profesor de Investigacion, Centro de Biologia Molecular Severo Ochoa, CSIC-UAM, Madrid …
Verified email at cbm.csic.es
Cited by 7692

The quasispecies (extremely heterogeneous) nature of viral RNA genome populations: biological relevance—a review

E Domingo, E Martínez-Salas, F Sobrino… - Gene, 1985 - Elsevier
We review evidence that cloned (or uncloned) populations of most RNA viruses do not consist
of a single genome species of defined sequence, but rather of heterogeneous mixtures of …

Structural insights into viral IRES-dependent translation mechanisms

G Lozano, E Martínez-Salas - Current opinion in virology, 2015 - Elsevier
Highlights • Viral IRESs adopt diverse three-dimensional structures. • Evolutionary conserved
motifs preserve RNA structure and RNA-protein interactions. • Picornavirus IRESs differ in …

Picornavirus IRES elements: RNA structure and host protein interactions

E Martínez-Salas, R Francisco-Velilla… - Virus research, 2015 - Elsevier
Internal ribosome entry site (IRES) elements were discovered in picornaviruses. These
elements are cis-acting RNA sequences that adopt diverse three-dimensional structures and …

IRES interaction with translation initiation factors: functional characterization of novel RNA contacts with eIF3, eIF4B, and eIF4GII.

SL De Quinto, E Lafuente, E Martínez-Salas - Rna, 2001 - rnajournal.cshlp.org
… by the Lb protease cleavage+ Therefore, the p220 crosslinked to the IRES contains both
forms of eIF4G, confirming previous data from our laboratory (López de Quinto & Martínez-Salas

The 3′ end of the foot-and-mouth disease virus genome establishes two distinct long-range RNA–RNA interactions with the 5′ end region

…, M Saiz, E Martínez-Salas - Journal of General …, 2006 - microbiologyresearch.org
… Lopez de Quinto S., Sáiz M., de la Morena D., Sobrino F., Martínez-Salas E. 2002; IRES-driven
translation is stimulated separately by the FMDV 3′-NCR and poly(A) sequences. …

A novel role for Gemin5 in mRNA translation

…, J Ramajo, N Fernández, E Martínez-Salas - Nucleic acids …, 2009 - academic.oup.com
In eukaryotic cells translation initiation occurs through two alternative mechanisms, a cap-dependent
operating in the majority of mRNAs, and a 5′-end-independent driven by internal …

Functional interactions in internal translation initiation directed by viral and cellular IRES elements

E Martínez-Salas, R Ramos… - Journal of General …, 2001 - microbiologyresearch.org
… 1F1), directing intramolecular RNA–RNA interactions (Ramos & Martínez-Salas, 1999R102
). In agreement with the latter model, the PTB protein that seems to act as a RNA chaperone …

Relevance of RNA structure for the activity of picornavirus IRES elements

O Fernández-Miragall, SL de Quinto, E Martínez-Salas - Virus research, 2009 - Elsevier
The RNA of all members of the Picornaviridae family initiates translation internally, via an
internal ribosome entry site (IRES) element present in their 5′ untranslated region. IRES …

Internal ribosome entry site biology and its use in expression vectors

E Martı́nez-Salas - Current opinion in biotechnology, 1999 - Elsevier
Internal ribosome entry sites (IRESs) are cis-acting elements that recruit the small ribosomal
subunits to an internal initiator codon in the mRNA with the help of cellular trans-acting …

The impact of RNA structure on picornavirus IRES activity

E Martínez-Salas - Trends in microbiology, 2008 - cell.com
Internal ribosome entry site (IRES) elements consist of cis-acting regions that recruit the
translation machinery to an internal position in the mRNA. The biological relevance of RNA …