User profiles for D. Poovathumkadavil
 | Divyasree PoovathumkadavilUniversity of Birmingham Verified email at bham.ac.uk Cited by 130 |
[PDF][PDF] The structural mechanism of dimeric DONSON in replicative helicase activation
…, A Skagia, C Fernandez-Cuesta, D Poovathumkadavil… - Molecular Cell, 2023 - cell.com
The MCM motor of the replicative helicase is loaded onto origin DNA as an inactive double
hexamer before replication initiation. Recruitment of activators GINS and Cdc45 upon S-…
hexamer before replication initiation. Recruitment of activators GINS and Cdc45 upon S-…
[HTML][HTML] TRAIP resolves DNA replication-transcription conflicts during the S-phase of unperturbed cells
…, A Reynolds-Winczura, D Poovathumkadavil… - Nature …, 2023 - nature.com
Cell division is the basis for the propagation of life and requires accurate duplication of all
genetic information. DNA damage created during replication (replication stress) is a major …
genetic information. DNA damage created during replication (replication stress) is a major …
[HTML][HTML] A cell cycle-coordinated Polymerase II transcription compartment encompasses gene expression before global genome activation
…, JW Wragg, D Poovathumkadavil… - Nature …, 2019 - nature.com
Most metazoan embryos commence development with rapid, transcriptionally silent cell
divisions, with genome activation delayed until the mid-blastula transition (MBT). However, a set …
divisions, with genome activation delayed until the mid-blastula transition (MBT). However, a set …
Mitotic replisome disassembly depends on TRAIP ubiquitin ligase activity
…, RM Jones, D Poovathumkadavil… - Life Science …, 2019 - life-science-alliance.org
We have shown previously that the process of replication machinery (replisome)
disassembly at the termination of DNA replication forks in the S-phase is driven through …
disassembly at the termination of DNA replication forks in the S-phase is driven through …
[HTML][HTML] The p97 segregase cofactor Ubxn7 facilitates replisome disassembly during S-phase
Z Tarcan, D Poovathumkadavil, A Skagia… - Journal of Biological …, 2022 - ASBMB
Complex cellular processes are driven by the regulated assembly and disassembly of large
multiprotein complexes. While we are beginning to understand the molecular mechanism for …
multiprotein complexes. While we are beginning to understand the molecular mechanism for …
The p97 cofactor Ubxn7 facilitates replisome disassembly during S-phase
Complex cellular processes are driven by the regulated assembly and disassembly of large
multi-protein complexes. In eukaryotic DNA replication, whilst we are beginning to …
multi-protein complexes. In eukaryotic DNA replication, whilst we are beginning to …
Ubiquitin ligase TRAIP plays an essential role during the S-phase of unperturbed cell cycle in the resolution of DNA replication–transcription conflicts
S Scaramuzza, MM Sadurni, D Poovathumkadavil… - bioRxiv, 2022 - biorxiv.org
Cell division is the basis for the propagation of life and requires accurate duplication of all
genetic information. DNA damage created during replication (replication stress) is a major …
genetic information. DNA damage created during replication (replication stress) is a major …
A cell cycle-coordinated nuclear compartment for Polymerase II transcription encompasses the earliest gene expression before global genome activation
…, HV Nguyen, J Wragg, D Poovathumkadavil… - bioRxiv, 2018 - biorxiv.org
Most metazoan embryos commence development with rapid cleavages without zygotic
gene expression and their genome activation is delayed until the mid-blastula transition (MBT). …
gene expression and their genome activation is delayed until the mid-blastula transition (MBT). …
Mitotic replisome disassembly in vertebrates
Recent years have brought a breakthrough in our understanding of the process of eukaryotic
DNA replication termination. We have shown that the process of replication machinery (…
DNA replication termination. We have shown that the process of replication machinery (…
Mitotic replisome disassembly in vertebrates
Recent years have brought a breakthrough in our understanding of the process of eukaryotic
DNA replication termination. We have shown that the process of replication machinery (…
DNA replication termination. We have shown that the process of replication machinery (…