Background: Canadians are engaged in an intense debate about the relative merits of
private for-profit versus private not-for-profit health care delivery. To inform this debate, we …

The article presents an historical account of the prevalence of obesity in medical history.
Obesity was viewed differently at different times of history. Hippocrates gave importance to …

The obesity epidemic in the United Kingdom is out of control, and none of the measures
being undertaken show signs of halting the problem, let alone reversing the trend. The United …

ADP ribosylation factor 1 (Arf1) plays a critical role in regulating secretory traffic and membrane
transport within the Golgi of eukaryotic cells. Arf1 is activated by guanine nucleotide …

ContextPrivate for-profit and private not-for-profit dialysis facilities provide the majority of
hemodialysis care in the United States. There has been extensive debate about whether the …

The coevolution of mammalian hosts and their beneficial commensal microbes has led to
development of symbiotic host–microbiota relationships 1 . Epigenetic machinery permits …

Nonalcoholic fatty liver disease (NAFLD), a common prelude to cirrhosis and hepatocellular
carcinoma, is the most common chronic liver disease worldwide. Defining the molecular …

Exposure to nephrotoxic medication is among the most common causes of acute kidney
injury (AKI) in hospitalized patients. Here we conducted a prospective quality improvement …

Background. Clostridium difficile is a leading hospital-acquired infection. Many patients
remain symptomatic for several days on appropriate antibiotic therapy. To assess the …

Mucosal barriers are densely colonized by pathobiont microbes such as Candida albicans,
capable of invasive disseminated infection. However, systemic infections occur infrequently …